This case report highlights that Tjalma Syndrome may present as a main symptom of systemic lupus erythematosus and should be considered in patients with ascites, pleural effusions, and elevated CA-125 levels.
12 citations
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January 2016 in “Journal of Clinical and Investigative Dermatology” This study examines how the Severity of Alopecia Tool score was used to assess Alopecia Areata in patients while excluding systemic conditions that might affect vitamin D levels, but reports no new clinical results.
June 2024 in “Research Square (Research Square)” This study found that among patients with systemic lupus erythematosus, the absence of skin rash and low levels of complement C3 were significant risk factors for developing lupus nephritis, with their combination demonstrating good predictive diagnostic value.
5 citations
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May 2023 in “Frontiers in immunology” This review discusses how environmental factors like lifestyle, nutrition, and vitamin deficiencies may influence autoimmune diseases such as MS, SLE, and AA, highlighting associations with vitamin D levels and dietary interventions, but notes a lack of conclusive evidence for their roles in disease pathogenesis.
December 2023 in “International Journal of Research in Dermatology” This study evaluated hormonal differences in males with early androgenetic alopecia, finding increased serum testosterone, prolactin, LH, LH/FSH, and FAI levels, with decreased FSH and SHBG levels, compared to controls without hair loss.
May 2026 in “Endocrine Connections” This review posits that alopecia in PCOS results from the interaction between local follicular signaling failures, insulin resistance, inflammation, and genetic predispositions, rather than solely from androgen excess, and recommends a systems-level framework for its management.
2 citations
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January 2022 in “BioMed Research International” This study found that using an LED array with an 863 nm wavelength delayed tumor development and reduced systemic inflammatory cytokines in DMBA/TPA-induced mouse skin tumors, suggesting potential but limited benefits of light therapy.
June 2025 in “Academic Medical Journal” This study suggests elevated homocysteine levels may serve as a biomarker for disease severity and vascular risk in cutaneous lupus erythematosus, indicating potential therapeutic benefits from B-vitamin supplementation and lifestyle changes.
1 citations
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December 2021 in “American Journal of Obstetrics and Gynecology” This study observed that hair cortisol levels increased during pregnancy and positively correlated with certain systemic cytokines postpartum, suggesting potential associations with perinatal outcomes.
2 citations
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December 2022 in “The Journal of Dermatology” This study found that patients with hidradenitis suppurativa had significantly higher levels of cell-free DNA in their serum compared to healthy controls, suggesting its potential as a biomarker for the disease.
January 2026 in “Phaidra - Repository of the University of Veterinary Medicine, Vienna” In this study, researchers assessed cortisol levels in wolves by comparing hair and fecal samples and found a significant correlation, indicating that hair cortisol accurately reflects systemic levels, but season and body region affect results.
54 citations
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April 2011 in “Journal of Multidisciplinary Healthcare” This study found that African-American and Hispanic patients with systemic lupus erythematosus reported higher levels of unmet psychological needs and may be more prone to depression and anxiety due to SLE-related challenges.
16 citations
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July 2002 in “Australasian Journal of Dermatology” This case report illustrates the risk of skin necrosis in patients with high antiphospholipid antibody levels after stopping anticoagulation therapy, highlighting the necessity for careful monitoring.
June 2026 in “Indian Dermatology Online Journal” This study in North India found that patients with alopecia areata have significantly higher levels of coagulation markers, metabolic dysregulation, and systemic inflammation compared to healthy controls, and these factors are linked with disease severity, indicating potential systemic implications beyond localized hair loss.
May 2025 in “The Journal of Rheumatology” In this case report, a woman with unexplained hair loss and high ANA levels developed systemic lupus erythematosus, highlighting the importance of monitoring autoantibodies for early lupus detection and management.
15 citations
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July 2020 in “Dermatologic Therapy” This review discusses the pathophysiology, diagnosis, systemic associations, and treatments for female pattern hair loss and reports no new clinical findings.
May 2026 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft” This guideline reports that corticosteroids are the only topical treatment for alopecia areata with a high recommendation level, while systemic corticosteroids and JAK inhibitors are recommended for adults.
June 2026 in “kerbala journal of pharmaceutical sciences” In this case-control study, individuals with alopecia areata showed significantly elevated levels of inflammatory markers IL-4, IFN-γ, and CRP, as well as reduced serum Folate and Ferritin, suggesting the condition's multifactorial pathophysiology involves immune activation, systemic inflammation, and micronutrient deficiencies.
71 citations
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May 2019 in “Rheumatology” This study observed that PD-1+CXCR5-CD4+T peripheral helper cells are significantly elevated in patients with systemic lupus erythematosus and are correlated with disease activity indicators, suggesting their potential role in lupus pathogenesis.
18 citations
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November 2011 in “Health & Social Work” This study found that among patients with systemic lupus erythematosus, those with chronic symptoms, lower education levels, or no health insurance reported higher levels of depression and anxiety.
11 citations
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October 2021 in “Journal of The European Academy of Dermatology and Venereology” This study found that topical finasteride significantly increased hair count in men with androgenetic alopecia compared to placebo while maintaining similar efficacy to oral finasteride but with lower systemic exposure and a reduced impact on serum DHT levels, potentially minimizing sexual side effects.
11 citations
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February 2020 in “Dermatology and therapy” This study reported that four patients with lichen planopilaris showed dramatic improvement, including symptom reduction and hair regrowth, after treatment with low-level light therapy.
1 citations
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January 2018 in “Indian Journal of Dermatology/Indian journal of dermatology” This report describes cases of transient thyrotoxicosis potentially linked to oral retinoid treatment, suggesting a possible mechanism involving increased iodine uptake by thyroid cells.
June 2025 in “Neurology India” This case report describes a young girl with a rare association of anti-SRP positive necrotizing autoimmune myopathy and systemic lupus erythematosus, who responded well to corticosteroid treatment.
November 2024 in “International Journal of Research in Medical Sciences” This case report describes a 30-year-old woman with severe hypoalbuminemia related to suspected SLE, who showed improvement in albumin levels after three days of treatment including IV albumin and dietary protein.
September 2024 in “Journal of the American Academy of Dermatology” PRO-C22 can help diagnose and monitor the severity of hidradenitis suppurativa.
January 2024 in “Brazilian Journal of Hair Health” Combining low-level laser therapy with topical corticosteroids effectively improved Lichen Planopilaris symptoms.
June 2022 in “Rheumatology research” This case report suggests that systemic lupus erythematosus can be a rare cause of severe hypercalcemia, potentially due to stimulating parathyroid hormone receptor autoantibodies.
213 citations
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June 2017 in “Rheumatology” This guideline outlines the management of systemic lupus erythematosus in adults but reports no new clinical findings.
7 citations
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October 2024 in “Acta Dermato Venereologica” This study found that patients with alopecia areata had higher systemic inflammation markers compared to healthy controls, and these markers were associated with a greater risk of severe disease.