February 2026 in “Cureus” This case report highlights that alopecia areata can mimic syphilitic alopecia in patients with recent or active syphilis, emphasizing the importance of trichoscopy in accurately diagnosing alopecia types and preventing misdiagnosis.
45 citations
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January 2015 in “Dermatology” In this study, 41.6% of patients with secondary syphilis exhibited syphilitic alopecia, with the 'moth-eaten' pattern most commonly observed through trichoscopy.
53 citations
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May 1995 in “Journal of The American Academy of Dermatology” This article describes two cases where essential alopecia was the initial sign of syphilitic infection, examining the clinical and histopathologic features observed.
1 citations
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January 2012 in “Médecine et Maladies Infectieuses” The man's symptoms improved significantly after penicillin treatment for syphilis.
4 citations
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March 2020 in “Berkala Ilmu Kesehatan Kulit dan Kelamin” This case report noted that HIV-infected men who have sex with men are at a higher risk of syphilis, requiring careful staging and prolonged serologic monitoring to assess treatment success.
3 citations
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January 2015 in “Dermatology Online Journal” This case report highlights a patient whose essential syphilitic alopecia was the only symptom of syphilis, which improved after benzathine penicillin treatment, emphasizing alopecia as a potential sign of syphilis.
4 citations
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August 2002 in “British Journal of Ophthalmology” This study suggests that intralesional cidofovir might be a treatment option for SCC, as it showed a successful outcome without systemic toxicity in the reported case.
2 citations
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December 2012 in “Acta Facultatis Medicae Naissensis” This article presents a case of syphilitic alopecia in a man, where treatment with benzathine penicillin G led to dramatic hair regrowth and resolution of syphilitic lesions within three months.
January 2025 in “The Pediatric Infectious Disease Journal” This report details a rare case of late latent syphilis in a 17-year-old male with unusual symptoms like polyarthritis and hair loss, which resolved following antibiotic treatment, highlighting varied syphilis presentations and the importance of STI screening, especially in high-risk groups.
January 2026 in “Journal of Comprehensive Science (JCS)” This case report highlights the severe manifestations of early congenital syphilis and underscores the crucial need for early diagnosis and treatment to improve outcomes in affected infants.
1 citations
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March 2024 in “Oxford Medical Case Reports” In this case study, researchers reported that moth-eaten alopecia was the only clinical sign of secondary syphilis in a 28-year-old man from Nepal, and treatment with Benzathine Penicillin G led to complete hair regrowth within four months.
1 citations
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July 2020 in “Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya” This case report describes a patient with HIV who experienced overlapping symptoms of primary and secondary syphilis and showed clinical and serological improvement after treatment with benzathine penicillin and antiretroviral drugs.
June 2025 in “British Journal of Dermatology” This case series observed the diagnostic challenges of secondary syphilis, highlighting diverse presentations such as rashes and systemic symptoms that can mimic other conditions, underscoring the importance of dermatological review, serological testing, and interdisciplinary care for effective treatment and management.
2 citations
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March 2005 in “Journal of the American Academy of Dermatology” This study found that using an overnight peel treatment for 3 months increased wrinkle spacing, leading to an average reduction in wrinkles of 39% in 67% of participants.
The document concludes that most hair loss treatments don't work, balding isn't caused by dandruff, and hair loss may indicate serious health issues that require medical attention.
29 citations
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January 2017 in “Skin appendage disorders” This case study highlights the importance of considering syphilis in the differential diagnosis for hair loss, as patients with the infection may present with non-typical alopecia patterns.
1 citations
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January 1980 in “Archives of Dermatology” This exchange discusses interpretations of syphilitic chancres, noting disagreement over whether multiple lesions are atypical given historical references that describe primary chancres as often being single.
December 2008 in “中華皮膚科醫學雜誌” This case report describes a 35-year-old Taiwanese man whose hair loss improved significantly after treatment for syphilis, suggesting a link between his condition and the infection.
Hair loss should be medically treated, as non-medical treatments are ineffective and hair loss can indicate serious health issues.
1 citations
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July 2025 in “Dermatology Reports” This case report highlights a rare instance of syphilitic alopecia and ocular syphilis in an immunocompetent, HIV-negative woman, showing that syphilis-directed treatment led to symptom reversal, emphasizing the need to consider syphilis in the differential diagnosis for atypical alopecia.
13 citations
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October 2021 in “Anais Brasileiros de Dermatologia” This article discusses how dermoscopy, particularly "entomodermoscopy," aids in diagnosing skin infestations and infectious dermatoses, enhancing clinical evaluations, and monitoring treatment efficacy for conditions like scabies, pediculosis, myiasis, and tungiasis.
7 citations
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January 2015 in “Current problems in dermatology” This chapter reviews common drug-related and systemic disorder-induced alopecias, focusing on their epidemiology, causes, symptoms, diagnosis, and treatment, but reports no new findings.
1 citations
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January 2017 in “Japanese Journal of Oral & Maxillofacial Surgery” In this case study, a woman with secondary syphilis showed significant improvement following treatment with benzyl penicillin potassium, as evidenced by a 3.7-fold decrease in rapid plasma reagin levels.
April 2026 in “Frontiers in Medicine” This case study reports a 26-year-old male with secondary syphilitic alopecia misdiagnosed as alopecia areata, likely contracted through non-penetrative sexual contact. Effective treatment with intramuscular benzathine penicillin G led to complete hair regrowth within three months.
35 citations
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January 2019 in “Clinics in Dermatology” This review discusses contemporary issues in syphilis diagnosis and management, emphasizing the importance of recognizing and addressing both biomedical and psychosocial aspects, but provides no new clinical results.
6 citations
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September 2011 in “Journal of the American Academy of Dermatology” This report describes a case of secondary syphilis with an unusual folliculocentric papular eruption in an HIV-positive patient, underlining the diagnostic challenges and importance of biopsy with treponemal staining in such cases.
2 citations
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October 2010 in “Reviews in Medical Microbiology” This review discusses syphilis and reports no new clinical findings; it highlights the need for improved prevention and diagnosis to address increasing infection rates globally and in Hungary.
April 2024 in “International Journal of Sexually Transmitted Diseases” This study observed a marked increase in syphilis frequency within the studied population in 2020, along with dynamic patterns of clinical manifestations and increasing re-infection rates.
7 citations
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January 2018 in “International Journal of Dermatology” Syphilis can cause hair loss without other symptoms and should be considered when diagnosing unexplained hair loss.
7 citations
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November 2006 in “Pediatric Dermatology” This article describes the first reported case of alopecia in a neonate with congenital syphilis.