100 citations
,
May 2003 in “Journal of Neuroscience” This study found that neuroactive steroids like DHEA and pregnenolone influence cocaine-induced appetence in mice through their interaction with the ς1 receptor, suggesting a role in individual vulnerability to addiction.
In this study, researchers analyzed the waters of Ladakh's hotsprings, identifying 27 bioactive compounds with potential health benefits, but emphasize that further clinical trials are needed to confirm their therapeutic efficacy and safety.
11 citations
,
February 2021 in “Trends in Food Science and Technology” This review explores the potential of edible flowers, particularly the genus Impatiens, for their chemical, nutritional, and bioactive properties but does not report new clinical findings.
September 2021 in “Research Square (Research Square)” This study found that measuring specific steroid hormone levels can aid in diagnosing P450 oxidoreductase deficiency, a subtype of congenital adrenal hyperplasia, by distinguishing affected patients from healthy individuals.
In this study involving 13 patients with vitiligo-associated leukotrichia, minimal hair repigmentation was observed following treatment with fractional CO₂ laser and topical betamethasone, though the method was well tolerated, highlighting the need for further research to optimize treatment parameters.
27 citations
,
February 2014 in “Planta Medica” This study found that Scutellaria baicalensis extract and its main component baicalin inhibited androgen activation signaling and promoted proliferation of human dermal papilla cells, suggesting potential use in treating androgen-associated disorders.
5 citations
,
April 2024 in “ACS Chemical Neuroscience” This study developed and validated a highly sensitive method using ultrahigh-performance liquid chromatography with tandem mass spectrometry for accurately analyzing nine neuroactive steroids in human serum, which could enhance understanding of disease pathophysiology and support new biomarker and therapeutic discovery.
65 citations
,
April 2018 in “Oncotarget” This review discusses the potential carcinogenic effects of anabolic androgenic steroids, particularly regarding Leydig cell tumors, and highlights the need for preventive information campaigns due to associated health risks.
46 citations
,
September 2011 in “Journal of Endocrinology” This study suggests that 5α-reduced glucocorticoids may have anti-inflammatory potential and could serve as biomarkers for liver inflammation in metabolic disease, with implications for drug development.
25 citations
,
June 2002 in “Steroids” This study examined 4-azasteroids using 13C-NMR spectroscopy, detailing the NMR spectrum assignments and reporting a new molecular complex of finasteride with dioxane.
13 citations
,
January 2015 in “Steroids” This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.
1 citations
,
October 2017 in “Elsevier eBooks” This review examines the effects of antiandrogens on female reproductive systems, particularly regarding environmental endocrine disruptors, and presents no new research findings.
August 2025 in “Al-Salam Journal for Medical Science” This paper reviews current knowledge about the structural formation and classification of steroid hormones, highlighting the importance of understanding their role in health and disease. It also identifies research gaps and suggests future studies to improve clinical practices and treatment plans.
108 citations
,
November 1980 in “British Journal of Dermatology” This article reviews the current status of oral retinoids in dermatology and reports no new clinical findings.
106 citations
,
April 2010 in “ACS Nano” This study found that about 80% of known fullerene-binding proteins rank in the top 10% of scorers for C60 docking sites, confirming the accuracy of the predictive model used.
July 2025 in “Dermatologica Sinica” In this study, compound glycyrrhizin promoted hair regrowth in a testosterone-induced alopecia mouse model and increased human hair dermal papilla cell proliferation, likely through activating the Wnt/β-catenin pathway.
April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that CCCA in women of African descent is associated with molecular changes, including dysregulation of fatty acid metabolism and fibrosis pathways, suggesting potential targets for new treatments.
July 2014 in “Elsevier eBooks” The document concludes that various hypersensitivity diseases in horses can be diagnosed and treated with methods like immunotherapy and medication, and early aggressive treatment is crucial for severe diseases like equine cutaneous pythiosis.
97 citations
,
November 1986 in “Journal of Steroid Biochemistry” This review discusses the pharmacological properties and clinical applications of cyproterone acetate and similar antiandrogens, noting previous failures in local applications due to concentration limitations; it reports no new empirical results.
37 citations
,
October 2006 in “Steroids” This paper describes recent advancements in the synthesis of thiasteroids but reports no new experimental results, noting that introducing heteroatoms in steroidal structures has potential biological effects.
29 citations
,
October 1988 in “Journal of Steroid Biochemistry” This review discusses the use of antiandrogens for various conditions like prostate cancer and highlights their potential benefits in remission rates and symptom improvement, but it reports no new clinical results.
27 citations
,
January 1984 in “Pharmacology & Therapeutics” This review discusses androgen manipulation strategies for conditions like benign prostatic hyperplasia and prostatic carcinoma but reports no new clinical results.
19 citations
,
June 2021 in “The world journal of men's health” This review examines the negative effects of anabolic-androgenic steroid use on the male reproductive system, including impaired testosterone production, sperm production issues, and adverse metabolic consequences without reporting new clinical results.
17 citations
,
June 1996 in “The Journal of Steroid Biochemistry and Molecular Biology” In this study, FCE 28260 showed greater potency than finasteride in inhibiting 5α-reductase enzymes and reducing prostate DHT levels in rats.
4 citations
,
October 2024 in “Heliyon” This study characterized the CYP154C7 enzyme from *Streptomyces* sp. PAMC26508, highlighting its ability to hydroxylate steroids efficiently, particularly androstenedione, and identified key amino acids important for substrate selectivity and catalytic efficiency.
1 citations
,
October 2025 in “Frontiers in Cardiovascular Medicine” This review examines AAS-related deaths and finds that anabolic-androgenic steroid abuse may lead to severe cardiac abnormalities, contributing to fatal arrhythmias and sudden cardiac death in young athletes and bodybuilders.
July 2026 in “International Journal of Drug Delivery Technology” This study found that a combination of curcumin and piperine demonstrated moderate antioxidant activity, negligible cytotoxicity, and significant potential for promoting hair regrowth in rat models of alopecia, suggesting it could be a safe and effective natural alternative for managing hair loss.
This review reports that extracts from the plant Eclipta alba, traditionally used in herbal medicine, may promote hair growth by inhibiting TGF-β1 expression and functioning as a 5α-reductase inhibitor, potentially benefiting androgenic alopecia treatment.
9 citations
,
January 2019 in “Postepy Dermatologii I Alergologii” The skin acts like an endocrine organ, making hormones that affect skin diseases and respond to stress.
108 citations
,
January 2010 in “International Journal of Andrology” This study concluded that mixtures of weak endocrine disruptors, such as parabens and azole fungicides, can produce combination effects that should be considered in regulatory risk assessments to avoid underestimating potential risks.