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This study found that gonadal steroid hormones influence alopecia areata in C3H/HeJ mice, with estradiol promoting progression and dihydrotestosterone conferring resistance to disease onset.

This review discusses the relevance of human androgen receptor action in sports doping and examines the potential of cell-based biological assays for detecting androgenic anabolic steroid use, without presenting new research findings.

This study found that pregnane derivatives with higher lipophilicity, like compound 9d, had stronger androgen receptor binding and greater antiandrogenic effects in rats, correlating relative binding affinity with log P values.

This study found that specific steroids, particularly 5 and 7b, decreased growth of prostate and seminal vesicles and bound to the androgen receptor, showing comparable pharmacological activity to finasteride.

This study describes the molecular conformation and intermolecular interactions in the crystalline structure of the compound C24H31BrO4.

This study found that octahydrobenzo[c]quinolizin-3-one derivatives, particularly compound 3, were potent and selective inhibitors of the enzyme 5α-reductase type 1.

In this study, researchers found that steroidal 17β-carboxamides 1-4 significantly inhibited 5α-reductase enzyme activity and reduced prostate weight more effectively than finasteride in a hamster model, without toxic side effects, suggesting potential for treating benign prostatic hyperplasia.

In this study, researchers analyzed Vachellia nilotica and Senegalia ataxacantha from Katsina state, Nigeria, identifying various bioactive compounds in their shoots and suggesting their potential as raw materials for pharmaceutical antifungal therapies.

This study found that the phytosterols β-sitosterol, stigmasterol, and campesterol have low-to-negligible inhibitory activity against steroidal 5α-reductase type 2 compared to the synthetic inhibitor dutasteride, with β-sitosterol showing the highest activity among the tested phytosterols.

In this study, Zingiber junceum Gagnep. is documented for the first time as a species in Vietnam, and its micro-morphological traits and the phytochemical profiles of its various extracts are detailed, highlighting the presence of several bioactive compounds.

This review focuses on coumarin analogs with potential antibreast cancer activities but reports no new clinical results, highlighting their mechanisms of action and structure-activity relationships.

9α-21-difluoro-21-desoxyhydrocortisone is the most effective at stopping hair growth in rats.

This study identified optimal parameters for extracting oil from Urtica dioica roots to maximize phytosterol content, using corn oil and a 1:5 raw material-extract ratio over a 6-hour maceration period.

This study found that several synthesized pregnane derivatives exhibited significant inhibitory effects on testosterone conversion to dihydrotestosterone and reduced related androgenic parameters in multiple pharmacological models.

This study found that two new progesterone derivatives showed higher antiandrogenic effects and 5α-reductase inhibition than finasteride in hamsters, particularly reducing seminal vesicle weight and flank organ size.

This article updates a prior work on pharmacophore modeling and highlights the advances in 3D database searching technologies for drug design, without presenting new research findings.

This review discusses the types, causes, and treatments for skin pigmentation disorders, examining clinically tested options including 25 plants, four marine species, and 17 medications.

This study found that endophytic bacteria isolated from Leea indica leaves showed high antioxidant activity, suggesting they could be a novel source of natural antioxidants.

In laboratory tests, this study found that aqueous extracts of Myristica fragrans showed significant membrane stabilization, suggesting its potential as an anti-inflammatory agent, though further research is needed to confirm its pharmacological application.

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.

Immunosuppressive therapy helps manage autoimmune diseases but carries risks like infection and potential for malignancy.

Fermentation of Finasteride with Ocimum sanctum L. creates new metabolite that inhibits tyrosinase.

This study found that human beard hair follicles metabolize dehydroepiandrosterone into various compounds at significantly higher rates than those reported for human skin, suggesting unique metabolic processes in hair follicles.

This study found that progesterone derivatives with chlorine or bromine substituents were effective in inhibiting 5α-reductase activity in human prostate and exhibited antiandrogenic effects in hamster flank organs.

This study found that several dehydroepiandrosterone ester derivatives effectively reduced prostate and seminal vesicle weight in gonadectomized hamsters treated with testosterone, demonstrating potential antiandrogen effects comparable to Finasteride.

This review examines the role of steroidal inhibitors in treating prostatic diseases but presents no new clinical results.

This review outlines the major health consequences of anabolic-androgenic steroid abuse, with a focus on sexual and reproductive issues, and suggests management prioritizes cessation and relapse prevention due to lack of robust randomized trials.

This review discusses the role of steroid 5 alpha reductase 2 in converting testosterone to DHT and its association with conditions like benign prostatic hyperplasia and prostate cancer; it reports no new results.

This review proposes focusing on relationships between neuroactive steroids and psychiatric disorder symptoms, rather than relying on traditional disorder classifications, and reports no new clinical findings.