January 2019 in “Journal of Pharmacognosy and Phytochemistry” This study identified 14 different phytoconstituents in the methanolic fruit extract of Citrullus colocynthis, suggesting its potential pharmacological importance.
March 2022 in “Research Square (Research Square)” This study found that certain bioactive mushroom metabolites may inhibit the enzyme SRD5A2 more effectively than finasteride in computational models, suggesting potential for further research in treating androgenic alopecia.
42 citations
,
March 2006 in “Drug Discovery Today: Therapeutic Strategies” This article discusses the need for rational strategies in developing hair loss drugs targeting specific events in hair follicle cycling, reporting no clinical findings but emphasizing the importance of understanding molecular controls.
41 citations
,
March 2007 in “Steroids” This article reviews recent advances in the synthesis of oxasteroids and reports no new experimental results.
21 citations
,
November 2021 in “Biomolecules” This review compiles information on traditional uses, phytoconstituents, and biological activities of Eclipta prostrata but reports no new experimental results; the authors call for more studies to understand its pharmacological mechanisms.
10 citations
,
April 2013 in “Revista cubana de plantas medicinales” This study found that Sida cordifolia L. from Colombia is rich in saponins, which may contribute to its antioxidant and antifungal properties.
2 citations
,
November 2017 in “Elsevier eBooks” This article discusses the role of the androgen receptor in regulating development and homeostasis, and reviews treatment approaches for conditions related to hormone imbalances, without reporting new clinical findings.
1 citations
,
December 2022 in “BMC Plant Biology” This study suggests that the floral secretions of Brasiliorchis schunkeana may attract Diptera as potential pollinators, but field observations are needed to confirm this pollination syndrome.
This study synthesized new heterocyclic steroid derivatives and reported their promising antiproliferative activity against breast and prostate cancer cell lines, highlighting selectivity and impact on signaling pathways even in cells resistant to certain treatments.
This review explores the synthesis and potential of azasteroids as novel drugs, discussing challenges in their production and reporting no new clinical results.
January 2021 in “Natural Products Chemistry & Research” This study found that Datura metel leaf and flower extracts could improve hair growth, with leaf extracts prompting quicker growth and mixed extracts enhancing overall regrowth effectiveness in animal models.
146 citations
,
January 2004 in “Hormones” This review explores the complex endocrine functions of human skin and its role as a peripheral endocrine organ, but reports no new clinical results.
1 citations
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March 2022 in “Applied Sciences” This study found that fermented red ginseng marc alleviated atopic dermatitis-like symptoms in mice, demonstrating antioxidant and anti-inflammatory effects similar to those of dexamethasone.
November 2025 in “Frontiers in Pharmacology” In this study, XZYFD, a Traditional Chinese Medicine formulation, was found to improve androgenetic alopecia in a testosterone-induced mouse model by promoting hair regrowth, restoring follicular morphology, and modulating androgen metabolism, MAPK signaling, and lipid metabolism pathways, suggesting potential benefits for patients with metabolic dysfunction.
23 citations
,
June 2019 in “Bioanalysis” This study found that monitoring endogenous steroid metabolites in serum may improve the detection of testosterone doping by highlighting promising biomarkers.
13 citations
,
July 2018 in “General and comparative endocrinology” This study observed that direct exposure to androgens in Western clawed frogs differentially affects thyroid receptor and deiodinase gene expression in male and female tissues, offering insight into sex-specific metabolic pathway activation.
August 2006 in “Experimental dermatology” This review discusses hormone-related hair disorders and explores potential therapies, including microparticle-based drug delivery systems, without providing new clinical findings.
1 citations
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April 2022 in “Clinical Cosmetic and Investigational Dermatology” In this study, a case of lichen amyloidosis on the scalp significantly improved with a 2-month topical treatment using clobetasol propionate/all-trans retinoic acid ointment.
38 citations
,
January 2012 in “Annales de Toxicologie Analytique” This study found that among bodybuilder-intended drugs from the black market, 33.8% of labeled products and 52.5% of steroidal oily solutions contained ingredients not matching their labels.
1 citations
,
January 2003 in “Chinese Journal of Pharmaceuticals” This study developed a new synthetic route for finasteride that omits the costly reagent 2,2′ dipyridyl disulfide, achieving an overall yield of 16%.
25 citations
,
July 1994 in “Archives of Dermatology” This study describes a patient with metastatic renal cell carcinoma who experienced a recurrence of pemphigus vulgaris after receiving interleukin 2 immunotherapy, suggesting a possible link between the treatment and autoimmune disease recurrence.
19 citations
,
June 1999 in “Steroids” This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.
218 citations
,
December 2011 in “Advances in Urology” This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.
18 citations
,
February 2016 in “The Journal of Clinical Endocrinology and Metabolism” This article reviews emerging opportunities and challenges in male reproductive medicine, including advancements and unmet needs in erectile dysfunction, androgen deficiency, and fertility, but reports no new clinical findings.
15 citations
,
September 1984 in “Veterinary Clinics of North America: Small Animal Practice” The document explains various skin conditions in cats and how to diagnose and treat them.
1 citations
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April 2009 in “Expert Review of Dermatology” This study found that the once-daily gel combining calcipotriene and betamethasone dipropionate was more effective and faster in treating scalp psoriasis compared to individual treatments, with a similar safety profile.
Use the least toxic, most specific treatments for skin diseases, considering side effects and individual patient needs.
53 citations
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October 1984 in “Endocrine reviews” This review highlights that idiopathic hirsutism is characterized by local hyperandrogenization affecting hair growth, without other signs of hyperandrogenism, and shows no new results; racial differences in prevalence are noted but not in androgenic steroids.
January 2019 in “ISGE series” This study found that estradiol and other sex steroids reduced the capture of monocytes by human endothelial cells in vitro, potentially inhibiting the formation of atherosclerosis by promoting nCAM polysialylation, which interferes with leukocyte tethering to the vascular endothelium.
January 2016 in “Springer eBooks” This review examines the clinical presentation and management strategies for alopecia areata, focusing on pediatric patients, and highlights the need for addressing its psychological impacts; it reports no new clinical findings.