Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study identified compounds from Laportea bulbifera with potential inhibitory effects on human steroid 5α-reductase 2, suggesting their application in treating benign prostatic hyperplasia.

This study identified key natural compounds such as polyphenols and flavonoids in tongue fern and established optimal extraction conditions using methanol.

This study identified various phytochemicals and compounds in Eclipta prostrata leaves using qualitative tests, FTIR, and GC-MS analysis, highlighting the presence of phytol and squalene among others.

This study suggests that three mushroom-derived bioactive compounds, Zhankuic acid A, Sterenin M, and Melleolide K, may effectively inhibit SRD5A2 and stabilize its interaction, indicating potential for treating androgenic alopecia.

This study identified that Mangkokan leaf extracts contain active compounds such as alkaloids, flavonoids, steroids, tannins, phenols, and saponins, using different solvents and FTIR analysis.

This study found that newly synthesized steroidal trienones demonstrated stronger 5α-reductase inhibitory activity compared to dienones in various biological models, suggesting potential for developing enhanced antiandrogenic drugs.

This report describes a 20-year-old Chinese man with a rare combination of congenital compound and blue melanocytic nevus associated with alopecia areata.

This review of Anemarrhena asphodeloides highlights its extensive historical use in Eastern traditional medicine and identifies diverse chemical compounds with numerous pharmacological activities, noting the need for further research to understand its mechanisms and ensure safe use.

This research focused on Eclipta prostrata, revealing unique anatomical features and bioactive compounds such as alkaloids and flavonoids that can aid in reliable identification and quality control of this medicinal herb, commonly used for hair growth and liver health.

This review discusses the degenerative effects of anabolic-androgenic steroids on the nervous system and reports no new experimental results, aiming to increase public awareness of their health risks.

This study identified LY191704 as a specific noncompetitive inhibitor of human 5 alpha-reductase type 1, which may be useful in treating endocrine disorders related to DHT overproduction.

This study developed a new competitive 5alpha-reductase inhibitor with an IC(50) of 0.84 microM using a novel chemical structure.

This study found that some synthesized heterocyclic derivatives showed promising 5α-reductase inhibitor, antiviral, and anti-tumor activities, surpassing several reference drugs in effectiveness.

This study found that LY320236 is a competitive inhibitor of type I and a non-competitive inhibitor of type II steroid 5alpha-reductase, indicating its potential as a dual inhibitor with differing modes of activity.

This article outlines the synthesis of spiro[cyclohexane‐1,2′‐[2 H ]indene] derivatives similar to known steroid 5α‐reductase inhibitors, but it does not report experimental findings.

This study identified that derivatives 4, 4b, and 4c strongly inhibited the enzyme type 1 5α-reductase and decreased reproductive organ weights in hamsters, suggesting potential as prodrugs for prostate tumor growth inhibition.

This paper discusses mechanisms by which various chemicals disrupt male sexual differentiation, concluding that mixture risk assessments should include a broader set of compounds beyond phthalates to address cumulative reproductive health risks.

This study found that age-related fluctuations in hormones and endocannabinoids in male C57BL/6 mice showed specific patterns, with peak values observed around 2.7 to 3.4 months, with these patterns seen in both plasma and hair but with different magnitudes.

This study reported that Neelibhringadi Kera Tailam, a traditional Ayurvedic herbal oil, contains bioactive compounds that may support hair health by stimulating growth, providing antimicrobial, antioxidant, and anti-inflammatory effects, and preventing hair loss, as evidenced by its physicochemical, phytochemical, and GC-MS analyses.

This study found that a hair tonic made with 30% ethanol extract from papaya fruit peel effectively promoted hair growth in guinea pigs, with results close to those of a positive control, and contains beneficial compounds like alkaloids and flavonoids.

This review of Lawsonia inermis L., or henna, details its bioactive compounds and historical uses in Unani medicine, including treatment for various conditions like ulcers and jaundice, while highlighting its potential for wound healing, hepatoprotective, and other effects, though further research is needed.

This study reports that newly synthesized steroidal trienones exhibit higher 5α-reductase inhibitory activity than dienones in various biological models, suggesting potential use in treating androgen-dependent diseases.

This review suggests that brassinosteroids may have similar biological activities in both plants and other organisms, prompting further exploration of steroid regulation mechanisms across different life forms.

This study reported that newly synthesized phenanthridin-3-one derivatives effectively inhibit human steroid 5-α-reductase.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

The document concludes that scientists created various steroids with different properties, including a more effective semi-synthetic vitamin D.

This study found that the leaf extract of Tectona grandis and its major bioactive constituents moderately inhibit the 5α-reductase enzyme, which is linked to androgenetic alopecia, and also possess anti-inflammatory properties, showing promise as dual-action candidates for managing this condition.

In this review, the authors found that cannabinoids and steroid-related drugs show potential for treating Tourette syndrome, but existing evidence is limited and further research is needed to confirm their efficacy and safety.

This study found that cortisone reductase deficiency is caused by inactivating mutations in the H6PD gene, affecting cortisol metabolism by preventing 11β-HSD1 enzyme function.

In this study, hirsute women treated with cyproterone acetate and ethinyloestradiol experienced significant reductions in sebum secretion and hair growth after several months.