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    Glossary Steroids

    Steroids are synthetic substances that mimic the effects of hormones like testosterone in the body. They are often used in medical treatments but can also lead to hair loss as a side effect, particularly when they disrupt the natural hormonal balance. In the context of hair biology, anabolic steroids can cause androgenic alopecia, a condition characterized by thinning hair and baldness, especially in genetically predisposed individuals. Key distinguishing characteristics include their potential to increase hair loss in both men and women, depending on individual sensitivity to androgens.

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    1. Steroid Sulfatase: Molecular Biology, Regulation, and Inhibition Endocrine Reviews · 2005 · 451 citations
    2. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    3. Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1) Journal of Investigative Dermatology · 2003 · 289 citations
    4. GhDET2, a steroid 5α‐reductase, plays an important role in cotton fiber cell initiation and elongation The Plant Journal · 2007 · 193 citations
    5. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996 · 136 citations
    6. LC‐MS/MS‐based method for long‐term steroid profiling in human scalp hair Clinical Endocrinology · 2015 · 134 citations
    7. Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism 2001 · 115 citations
    8. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne Cochrane library · 2009 · 112 citations
    9. Steroid sulfatase inhibitors Medicinal Research Reviews · 2004 · 108 citations
    10. Systemic Steroids With or Without 2% Topical Minoxidil in the Treatment of Alopecia Areata Archives of Dermatology · 1992 · 101 citations
    11. A preliminary study of steroid reproductive hormones in human hair The Journal of Steroid Biochemistry and Molecular Biology · 1998 · 89 citations
    12. Role of Transepidermal and Transfollicular Routes in Percutaneous Absorption of Steroids: In vitro Studies on Human Skin Skin Pharmacology and Physiology · 1994 · 82 citations
    13. Steroid Biomarkers and Genetic Studies Reveal Inactivating Mutations in Hexose-6-Phosphate Dehydrogenase in Patients with Cortisone Reductase Deficiency The Journal of Clinical Endocrinology and Metabolism · 2008 · 81 citations
    14. Intratesticular Control Of Steroidogenesis Clinical endocrinology · 1990 · 79 citations
    15. Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones International Journal of Pharmaceutics · 2006 · 75 citations
    16. Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders Current Pharmaceutical Design · 2011 · 72 citations
    17. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    18. The influence of selected steroid hormones on the physicochemical behaviour of DPPC liposomes Chemistry and Physics of Lipids · 2007 · 65 citations
    19. Anabolic androgenic steroids and carcinogenicity focusing on Leydig cell: a literature review Oncotarget · 2018 · 65 citations
    20. Steroid Sulfatase in the Human Hair Follicle Concentrates in the Dermal Papilla Journal of Investigative Dermatology · 2001 · 61 citations
    21. Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids Frontiers in endocrinology · 2018 · 61 citations
    22. Treatment of severe alopecia areata with intralesional steroid injections. PubMed · 2009 · 60 citations
    23. Social isolation‐induced increase in α<sub>4</sub>and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA<sub>A</sub>receptor function Journal of Neurochemistry · 2006 · 60 citations
    24. Local Injection of Steroids and Hair Regrowth in Alopecias Archives of Dermatology · 1960 · 57 citations
    25. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    26. Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells American journal of physiology. Cell physiology · 2006 · 56 citations
    27. Human Osteoblast-Like Cells Express Predominantly Steroid 5α-Reductase Type 1 The Journal of Clinical Endocrinology & Metabolism · 2002 · 56 citations
    28. GC-MS determination of steroids related to androgen biosynthesis in human hair with pentafluorophenyldimethylsilyl–trimethylsilyl derivatisation The Analyst · 1999 · 56 citations
    29. STEROIDS AND STEROID-LIKE COMPOUNDS Clinics in Sports Medicine · 1999 · 55 citations
    30. LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1. Proceedings of the National Academy of Sciences of the United States of America · 1993 · 53 citations