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The document concludes that research on sulfatase inhibitors should continue due to their potential in treating various diseases, despite some clinical trial failures.

High testosterone to epitestosterone ratio in hair could predict male-pattern baldness.

Fractional laser resurfacing is effective and safe for skin treatment, with benefits like less downtime and a low risk of adverse events.

Male skin gets drier and more alkaline as it ages, which may need different skincare than women's skin.

Systemic glucocorticosteroids are a primary treatment for various skin conditions but require careful management due to potential side effects and relapses.

Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Mutations in certain receptors can cause diseases and offer new treatment options.

A man's skin condition, pemphigus vulgaris, came back after he was treated with interleukin 2 for cancer.

Monitoring steroid hormones in blood can better detect testosterone doping.

The conclusion is that removing both ovaries is the best treatment for excess male hormones in postmenopausal women, with medication as another option, and managing insulin resistance is important for diagnosis and treatment.

Blocking neurosteroid production can lead to more seizures and faster epilepsy onset in rats.

Antiandrogen therapies are beneficial for treating skin and hair conditions related to androgen levels.

Curcumin and its derivatives can block an enzyme important for making testosterone, with one derivative being particularly strong.

Advancements in male reproductive medicine are ongoing, but more research and improved treatments are needed in several areas.

New treatments for skin conditions related to the sebaceous gland are being developed based on current research.

Two plywood factory workers developed contact dermatitis from phenol-formaldehyde resin, a known allergen.

Skin problems from transplant drugs are common and need careful management in organ transplant patients.

The enzyme type 1 5α-reductase is more active in the hair follicle's lower part than in the skin's outer layer.

Skin changes can indicate hormonal imbalances and help diagnose endocrine disorders.

Leflunomide and anthralin may effectively treat severe alopecia areata.

New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.

Many potential alopecia treatments need more testing to confirm they promote acceptable hair growth with minimal side effects.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

Tiny particles called extracellular vesicles show promise for skin improvement and anti-aging in facial care but face challenges like low production and lack of research.

Acne is caused by increased sebum, abnormal skin shedding, bacteria, and inflammation, not dirt; treatments vary from creams to antibiotics or isotretinoin, with severe cases needing a dermatologist's care.

Oral baricitinib and ruxolitinib are effective and safe for treating alopecia areata.