research 5α-Reductases in Human Physiology: An Unfolding Story
We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
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research 5α-Reductases in Human Physiology: An Unfolding Story
Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
research Interaction of Chronic Ethanol Exposure and Finasteride: Sex and Strain Differences
Finasteride reduces alcohol withdrawal effects, especially in female mice.
research Role of 5α-Reductase in Health and Disease
5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
research Treatment With and Withdrawal From Finasteride Alter Ethanol Intake Patterns in Male C57BL/6J Mice: Potential Role of Endogenous Neurosteroids
Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.
research Sex Differences in the Effect of Finasteride on Acute Ethanol Withdrawal Severity in C57BL/6J and DBA/2J Mice
Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.
research The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride
Pregnancy reduces anxiety in rats, but finasteride reverses this effect.
research Early Postnatal Allopregnanolone Levels Alteration and Adult Behavioral Disruption in Rats: Implications for Drug Abuse
Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
research Advances in Knowledge of Androgens: How Intentional and Accidental Neurosteroid Changes Inform Us of Their Action and Role
Finasteride can have lasting negative effects on brain function and behavior by disrupting neurosteroid production.
research Finasteride Blocks the Reduction in Ictal Activity Produced by Exogenous Estrous Cyclicity
research Progesterone Enhances Ethanol-Induced Modulation of Mesocortical Dopamine Neurons: Antagonism by Finasteride
Progesterone boosts alcohol's effect on brain, finasteride counters it.
research Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats
research Isoallopregnanolone Reduces Tic-Like Behaviors in the D1CT-7 Mouse Model of Tourette Syndrome
Isoallopregnanolone may be a safe and effective treatment for reducing tics in a mouse model of Tourette syndrome.
research The Impact of the 5α-Reductase Inhibitors on Male Sexual Function and Psychological Well-Being
5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.
research Effects of Altering Allopregnanolone Levels During Critical Neurodevelopmental Periods on Alcohol Consumption Vulnerability
Early NAS level changes affect alcohol consumption vulnerability.
research The Pathophysiology of Polycystic Ovary Syndrome
Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.
research Persistent Sexual Side Effects of Finasteride: Could They Be Permanent?
Finasteride may cause long-lasting sexual side effects.
research Relationships Between Cerebrospinal Fluid GABAergic Neurosteroid Levels and Symptom Severity in Men with PTSD
Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.
research Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride
Using finasteride or dutasteride may cause long-lasting erectile dysfunction.
research Side Effects of 5-Alpha Reductase Inhibitors: A Comprehensive Review
5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.
research Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia
5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.
research Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men
Finasteride can cause sexual problems and depression in young men.
research A Rapid Method for Obtaining Finasteride, a 5α-Reductase Inhibitor, from Commercial Tablets
Quickly get finasteride from tablets using easy methods.
research Allopregnanolone Is Required for Prepulse Inhibition Deficits Induced by D1 Dopamine Receptor Activation
Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.
research Hyperadrenocorticism in Ferrets
Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.
research Association Between 5-Alpha Reductase Inhibitor Use and the Risk of Depression: A Meta-Analysis
Using 5-alpha reductase inhibitors may increase the risk of mild depression.
research Neonatal Finasteride Administration Decreases Dopamine Release in Nucleus Accumbens After Alcohol and Food Presentation in Adult Male Rats
Finasteride given to baby rats reduces dopamine release and increases alcohol consumption in adult males.
research 5α-Reduced Glucocorticoids: A Story of Natural Selection
Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.
research Implications of Neuroimaging for the Treatment of Epilepsy
Neuroimaging suggests that treatments targeting brain steroids could help control epilepsy, especially types linked to the menstrual cycle.
research Early Postnatal Neuroactive Steroid Manipulation Differentially Affects Recognition Memory and Passive Avoidance Performance in Male Rats
Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.