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5α-reductase inhibitors may worsen sexual drive and spontaneous erections but don't worsen existing erectile or ejaculatory problems.

Minocycline may cause hair loss by increasing DHT levels, but finasteride can help counteract this effect.

The link between physical signs of high male hormones and hormone levels in women with PCOS changes with age.

Testosterone is key for male sexual function, and treating hormone imbalances can improve sexual issues.

Finasteride helps treat hair loss by blocking enzyme activity.

High-dose dutasteride reduces PMDD symptoms by stabilizing neurosteroid levels.

Ashwagandha may improve hormone levels and reduce hair loss in non-classical adrenal hyperplasia.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.

Spironolactone most effective for hirsutism, but has side effects.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Early treatment of acne is important to prevent scarring and improve appearance, using medications that can have side effects.

Gilles de la Tourette syndrome is treatable, with behavioral therapy as a recommended first option and other treatments available for more severe cases.

Neurosteroids change how GABA_A receptors work in the brain, which could be important for treating temporal lobe epilepsy.

Ovarian vein sampling helped diagnose rare ovarian tumors causing high testosterone, and surgery to remove the tumors lowered the testosterone levels.

A rare benign skin tumor showed unusual features of sebaceous and sweat glands, important for correct diagnosis.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The document says that understanding the causes of PCOS is important for treatment, especially in distinguishing the syndrome from just having cystic ovaries, and that losing weight is key for obese women with PCOS.

Different human traits like skin color and hair type vary between populations due to genetic adaptations to the environment.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Genetic mutations can affect female sexual development, requiring personalized medical care.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.

Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

DHT, a testosterone byproduct, causes male pattern baldness.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.