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Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Alopecia areata involves immune activation in the scalp, suggesting treatments targeting TH1, TH2, and IL-23 pathways.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Modern science supports the use of some Ayurvedic plants for health, as ancient practices suggested.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Human hair follicle organ culture is a useful model for hair research with potential for studying hair biology and testing treatments.

Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

The telogen phase of hair growth is active and important for preparing hair follicles for regeneration, not just a resting stage.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Men, especially older ones with health issues like prostate cancer, may have worse COVID-19 outcomes and could benefit from therapies targeting male hormones.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

Finasteride may cause long-lasting sexual side effects.

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

Inhibiting 5α-reductase can help reduce prostate cancer risk and improve treatment.

The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.

FGF signaling is a promising target for developing treatments for wounds, metabolic diseases, and cancer.

New treatments for Alopecia Areata show promise but need to be more effective and affordable.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.