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Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Fullerenes show potential in skin care but need more safety research.

Hair follicles are hormone-sensitive and involved in growth and other functions, with potential for new treatments, but more research is needed.

Androgens can both stimulate and cause hair loss, and understanding their effects is key to treating hair disorders.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

New hormonal contraceptives are safer, have fewer side effects, and offer health benefits for women.

Treatments for melanin disorders exist, but more effective options needed.

A three-month treatment with a GnRH agonist significantly lowered androgen levels and 5α-reductase activity in men with benign prostatic hyperplasia.

Inherited ichthyoses cause widespread skin scaling and thickening due to gene mutations.

The document concludes that minoxidil and finasteride are proven for hair growth, herbal remedies show promise, but more research is needed to confirm their effectiveness.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Some common medications can harm male fertility, but many effects can be reversed.

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

Hormonal treatments can help with acne but are not the first choice due to side effects and the need for careful patient selection.

Hormones, especially androgens, play a key role in acne, which can be a symptom of systemic diseases like PCOS and may require targeted treatment.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

The HR protein's role as a repressor is essential for controlling hair growth.

Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.

Minoxidil and finasteride treat hair loss; more research needed for other options.

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.

Pregnancy causes skin changes like darkening, hair thickening, nail changes, and increased risk of skin growths, most of which usually resolve after birth.

Blocking the enzyme 11β-HSD1 might help treat obesity and metabolic issues.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Overexpressing the mineralocorticoid receptor in mouse skin causes skin thinning, early skin barrier development, eye issues, and hair loss.

The document concludes that careful evaluation is key to diagnose and treat women with hair loss, with tests for thyroid, iron, and hormones as needed.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Finasteride effectively treats male pattern baldness, improving hair growth and density.

Cationic polymers improved liposome stability and increased skin absorption of aciclovir and minoxidil.