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This review explores the mechanisms of adult stem cell self-renewal, using skin as a model, and reports no new results but raises important unanswered questions in the field.

This article provides contact information for Bruce A. Morgan and features no new research findings.

This review suggests that MSC-derived conditioned media hold promise in dermatology, with studies indicating enhanced therapeutic effects when used alongside treatments like laser therapy and microneedling, leading to improved dermatological outcomes.

This study concluded that hair-derived stem cells from older donors may offer a promising alternative for autologous corneal endothelial replacement, potentially benefitting patients of various age groups.

This study found that knocking out the integrin β1 subunit in induced pluripotent stem cells enhanced their migration and improved their wound-healing effects in a mouse model.

This study found that implanting hair-follicle-associated pluripotent stem cell sheets in mice significantly accelerated wound closure and reduced scar formation compared to non-implanted controls.

In this study, the authors reported that combining PMSC-secretome and Wnt10b in a GelMA hydrogel scaffold promoted effective hair follicle biofabrication and hair growth in a small in vivo experiment. They emphasized the need for larger studies to confirm these results.

This symposium reviewed various topics in stem cell research related to skin biology, including mechanisms of skin regeneration, tumorigenesis, and pathways influencing melanoma stem cell behavior, but it reported no new clinical results.

This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.

This article reviews recent advancements in understanding skin stem cells and their roles in maintaining epidermal homeostasis and repairing wounds, without presenting new experimental findings.

This study found that activation of Wnt/β-catenin signaling in mouse testes promotes spermatogonial differentiation and reduces the stem cell pool, with SHISA6 inhibiting this process and maintaining stem cell characteristics.

This review discusses circadian clock regulation in stem cells and its role in processes like neurogenesis, but reports no new results; the authors emphasize its significance in stem cell function across various tissues.

This paper discusses the role of Runx1 in epithelial biology and pathology, highlighting its dual function as a tumor promoter and suppressor in different contexts, and reports no new experimental findings.

This review discusses the multiple layers of environmental controls on hair stem cell homeostasis and suggests that targeting these layers could offer safer regenerative medicine therapies without directly using stem cells.

This study found that dermal fibroblast cultures, especially those with higher alpha-smooth muscle actin expression, can be used to produce skin-derived precursor cells, unlike human hair follicle dermal papilla cultures.

This review article highlights recent progress and challenges in stem cell transplantation for regenerative medicine, emphasizing its potential in tissue repair for conditions like bone and cartilage injuries, neurological disorders, and blood diseases, while stressing the importance of overcoming current obstacles for future advancements.

The document concludes that both internal stem cell factors and external influences like the environment and hormones affect hair loss and aging, with potential treatments focusing on these areas.

This review synthesizes recent findings on the hair follicle stem cell niche and its complex interactions, exploring potential pathways for developing new hair growth therapies; it reports no new clinical results.

In this study, researchers found that Gab1 is critical in controlling the hair cycle and the self-renewal of hair follicle stem cells in mice.

This study found that the dermal papilla of the hair follicle regulates stem cell quiescence and regeneration by modulating Shh and Wnt signaling pathways, highlighting the importance of signaling cross talk in regeneration.

This study reviews the roles and mechanisms of MSC-derived exosomes in wound healing, noting their potential as promising cell-free therapies for cutaneous regeneration.

This study reported that treatments using ADSC-CM improved hair growth in all participants, with the most pronounced results after four sessions within three to four months.

This review discusses the identification and roles of different epidermal stem cell types in skin homeostasis and repair, and reports no new experimental findings.

This review discusses the mechanisms of skin aging, highlighting the roles of stem/progenitor cells, genetic and environmental factors, and suggests potential for cell-based therapies, but reports no new experimental findings.

This review discusses the use of stem cells and stem cell-derived products in burn wound healing, highlighting various stem cell sources, associated signaling pathways, and delivery methods, but reports no new clinical results.

This review discusses the mechanisms governing epidermal stem and progenitor cell differentiation, emphasizing the balance necessary for maintaining skin barrier function, and reports no new experimental findings.

This review discusses hair follicle stem cells for wound healing and reports no new clinical results, noting their potential but emphasizing the need for further understanding and safety in clinical applications.

This study found that adipose-derived stem cell-conditioned media improved skin flap survival following ischemia/reperfusion injury in mice by increasing cell proliferation and the number of hair follicles, mediated by IL-6.

Adding stem cells to fat grafts for facial rejuvenation might improve outcomes, but more research is needed to confirm safety and effectiveness.

This review discusses the potential of stem cell-derived extracellular vesicles for improving diabetic wound healing and highlights their mechanisms, limitations, and challenges, but provides no new clinical findings.