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    Glossary Stem Cell Differentiation

    process where unspecialized cells become specialized cell types

    Stem cell differentiation is the process by which unspecialized stem cells develop into specialized cells with distinct functions, such as skin cells, muscle cells, or nerve cells. This process is crucial for growth, development, and tissue repair, as it allows the body to generate the specific cell types needed for various functions and structures.

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    1. Circadian clock-mediated control of stem cell division and differentiation: beyond night and day Development · 2014 · 91 citations
    2. Thymosin Beta 4 Induces Hair Growth via Stem Cell Migration and Differentiation Annals of the New York Academy of Sciences · 2007 · 53 citations
    3. Mechanism of action of minoxidil in the treatment of androgenetic alopecia is likely mediated by mitochondrial adenosine triphosphate synthase-induced stem cell differentiation. PubMed · 2018 · 6 citations
    4. The Use of Stem Cell Differentiation Stage Factors (SCDSFs) Taken from Zebrafish Embryos during Organogenesis and Their Role in Regulating the Gene Expression of Normal and Pathological (Stem) Cells International Journal of Molecular Sciences · 2020 · 3 citations
    5. In vitro Differentiation of Adipose-Derived Stem Cells into Hair Cell-Like Cells in Guinea Pigs Journal of Otology · 2007 · 3 citations
    6. Shushing down the epigenetic landscape towards stem cell differentiation Development · 2010 · 1 citations
    7. Shifting IRES versus Cap-initiated translation during homeostatic stem cell differentiation and stress Science Advances · 2026
    8. Decision letter: Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo 2022
    9. Abstract C4: Sp2: A regulator of stem cell differentiation and tumorigenesis Cancer Research · 2009
    10. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    11. Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance 2016 · 26 citations
    12. The Role of ATP-dependent Chromatin Remodeling in the Control of Epidermal Differentiation and Skin Stem Cell Activity Stem cell biology and regenerative medicine · 2018
    13. MicroRNA-149-Mediated MAPK1/ERK2 Suppression Attenuates Hair Follicle Stem Cell Differentiation Human Gene Therapy · 2022 · 2 citations
    14. Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo eLife · 2023 · 23 citations
    15. Investigating the role of notch ligands regulating epidermal stem cell differentiation eScholarship@McGill (McGill) · 2025
    16. Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells BioMed research international · 2014 · 10 citations
    17. Fatty acid oxidation fuels mitochondrial respiration to drive epidermal stem cell fate and differentiation Nature Communications · 2026
    18. Hairless and Wnt Signaling: Allies in Epithelial Stem Cell Differentiation Cell Cycle · 2006 · 74 citations
    19. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling PLOS genetics · 2019 · 19 citations
    20. In vitro neural differentiation of CD34 + stem cell populations in hair follicles by three different neural induction protocols In vitro cellular & developmental biology. Animal · 2014 · 18 citations
    21. Differentiation of Human Pluripotent Stem Cells Into Definitive Endoderm Cells in Various Flexible Three-Dimensional Cell Culture Systems: Possibilities and Limitations Frontiers in Cell and Developmental Biology · 2021 · 13 citations
    22. In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin Iranian Biomedical Journal · 2019 · 10 citations
    23. CLK1 and its Effects on Skin Stem Cell Differentiation Digital WPI · 2010 · 1 citations
    24. Hair follicle stem cell differentiation is inhibited through cross‐talk between Wnt/β‐catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopecia British Journal of Dermatology · 2012 · 95 citations
    25. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    26. Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB Molecular Medicine Reports · 2013 · 19 citations
    27. Transcription Factor DLX5 Promotes Hair Follicle Stem Cell Differentiation by Regulating the c-MYC/microRNA-29c-3p/NSD1 Axis Frontiers in Cell and Developmental Biology · 2021 · 4 citations
    28. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    29. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    30. Lentiviral Arrays for Live-cell Dynamic Monitoring of Gene and Pathway Activity During Stem Cell Differentiation Molecular therapy · 2014 · 13 citations