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    Glossary Stem Cell Activation

    process stimulating dormant cells to divide and specialize

    Stem cell activation refers to the process by which dormant stem cells are stimulated to begin dividing and differentiating into specialized cell types. This is crucial for tissue repair and regeneration, as well as for maintaining healthy hair growth. In the context of hair, activating stem cells in hair follicles can potentially reverse conditions like alopecia by promoting the growth of new hair.

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    1. Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering Expert Opinion on Biological Therapy · 2013 · 74 citations
    2. The incidental pore: Ca<sub>V</sub>1.2 and stem cell activation in quiescent hair follicles Genes & development · 2013 · 3 citations
    3. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 1 citations
    4. Faculty Opinions recommendation of Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2013
    5. Dermal Papilla Cell-Derived Extracellular Vesicles Increase Hair Inductive Gene Expression in Adipose Stem Cells via β-Catenin Activation Cells · 2022 · 12 citations
    6. 1358 PRC1 fine-tunes gene repression and activation to safeguard skin epithelium development and stem cell specification Journal of Investigative Dermatology · 2018 · 1 citations
    7. 572 Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion Journal of Investigative Dermatology · 2022
    8. Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1 Journal of Investigative Dermatology · 2012 · 72 citations
    9. LB1031 Immune Cell-Mediated Amplification of Stem Cell Activation in Hairy Melanocytic Nevus via Osteopontin-CD44 Axis Journal of Investigative Dermatology · 2024 · 1 citations
    10. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment Development · 2003 · 182 citations
    11. PBX homeobox 1 enhances hair follicle mesenchymal stem cell proliferation and reprogramming through activation of the AKT/glycogen synthase kinase signaling pathway and suppression of apoptosis Stem Cell Research & Therapy · 2019 · 26 citations
    12. Hair follicle stem cell proliferation, Akt and Wnt signaling activation in TPA-induced hair regeneration Histochemistry and Cell Biology · 2017 · 30 citations
    13. RETRACTED: Tanshinone IIA Pretreatment Renders Free Flaps against Hypoxic Injury through Activating Wnt Signaling and Upregulating Stem Cell-Related Biomarkers International Journal of Molecular Sciences · 2014 · 6 citations
    14. mTOR signaling promotes stem cell activation via counterbalancing BMP-mediated suppression during hair regeneration 2015 · 71 citations
    15. TCDD-induced activation of aryl hydrocarbon receptor regulates the skin stem cell population Medical hypotheses · 2015 · 9 citations
    16. Lactate dehydrogenase activity drives hair follicle stem cell activation Nature cell biology · 2017 · 202 citations
    17. Glutamate transporter Slc1a3 mediates inter‐niche stem cell activation during skin growth EMBO journal · 2018 · 34 citations
    18. Decision letter: Stimulation of hair follicle stem cell proliferation through an IL-1 dependent activation of γδT-cells 2017
    19. Human umbilical cord mesenchymal stem cell-derived exosomes enhance follicular regeneration in androgenetic alopecia via activation of Wnt/β-catenin pathway Stem Cell Research & Therapy · 2025
    20. 277 HPV8 E6 induced STAT3 activation leads to hair follicle junctional zone keratinocyte stem cell proliferation and expansion in actinic keratoses 2023
    21. Competitive balance of intrabulge BMP/Wnt signaling reveals a robust gene network ruling stem cell homeostasis and cyclic activation Proceedings of the National Academy of Sciences · 2013 · 176 citations
    22. Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis 2024
    23. Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis Research Square (Research Square) · 2023
    24. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012 · 321 citations
    25. Type 2 Diabetic Mellitus Inhibits Skin Renewal through Inhibiting WNT-Dependent Lgr5+ Hair Follicle Stem Cell Activation in C57BL/6 Mice Journal of diabetes research · 2022 · 6 citations
    26. Additional file 1 of Autophagy induces hair follicle stem cell activation and hair follicle regeneration by regulating glycolysis Figshare · 2024
    27. 568 Autophagy Controls Epidermal Tumour Formation and Hair Follicle Stem Cell Activation Journal of Investigative Dermatology · 2022
    28. miR-22 promotes stem cell traits via activating Wnt/β-catenin signaling in cutaneous squamous cell carcinoma Oncogene · 2021 · 30 citations
    29. Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations Molecular Carcinogenesis · 2013 · 23 citations
    30. Adaptive Gelatin Microspheres Enhanced Stem Cell Delivery and Integration With Diabetic Wounds to Activate Skin Tissue Regeneration Frontiers in bioengineering and biotechnology · 2022 · 18 citations