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    Glossary SRD5A2 gene

    gene converts testosterone into potent androgen DHT

    The SRD5A2 gene provides instructions for making an enzyme called steroid 5-alpha reductase type 2. This enzyme is crucial for converting testosterone into dihydrotestosterone (DHT), a more potent androgen that plays a key role in the development of male characteristics and is also implicated in conditions like male pattern baldness and certain forms of alopecia.

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    Research 30 of 330

    1. Altered methylation pattern of the SRD5A2 gene in the cerebrospinal fluid of post-finasteride patients: a pilot study Endocrine connections · 2019 · 8 citations
    2. Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population Postępy Dermatologii i Alergologii · 2018 · 3 citations
    3. Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2 Biology · 2021 · 14 citations
    4. Worldwide cohort study of 46, XY differences/disorders of sex development genetic diagnoses: geographic and ethnic differences in variants Frontiers in Genetics · 2024 · 13 citations
    5. Molecular epidemiology of hypospadias: Review of genetic and environmental risk factors Birth Defects Research · 2003 · 103 citations
    6. 5α-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia International Journal of Cancer · 2006 · 57 citations
    7. Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer Endocrine Related Cancer · 2010 · 30 citations
    8. Rare and common genetic determinants of metabolic individuality and their effects on human health Nature Medicine · 2022 · 29 citations
    9. Identification of a Rare Variant in the <i>SRD5A2</i> Gene in Siblings With 46,XY Disorders of Sexual Development Case Reports in Genetics · 2025
    10. Adjuvant measures and genetic evaluations to improve results of hair transplantation Cellular and Molecular Biology · 2022
    11. Male-pattern hair loss: Comprehensive identification of the associated genes as a basis for understanding pathophysiology Medizinische Genetik · 2023
    12. Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes Journal of Investigative Dermatology · 1998 · 169 citations
    13. Analysis of genetic polymorphisms of steroid 5α-reductase type 1 and 2 genes in Korean men with androgenetic alopecia Journal of Dermatological Science · 2003 · 15 citations
    14. Study on genetic polymorphisms of androgen receptor gene and 5α-reductase genes of Han men with androgenetic alopecia in the Eastern China Chinese Journal of Dermatology · 2006
    15. Effects of Bioactive Composition in Oryza sativa L. cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells Agronomy · 2023 · 3 citations
    16. Association of childhood dehydroepiandrosterone sulfate concentration, pubertal development, and DNA methylation at puberty-related genes European Journal of Endocrinology · 2024 · 1 citations
    17. Resequencing Analyses Revealed Genetic Diversity and Selection Signatures during Rabbit Breeding and Improvement Genes · 2024
    18. The 5alpha-reductase type 1, but not type 2, gene is expressed in anagen hairs plucked from the vertex area of the scalp of hirsute women and normal individuals Brazilian Journal of Medical and Biological Research · 2003 · 17 citations
    19. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    20. Effects of finasteride on steroid production and gene expression in male fathead minnow (Pimephales promelas) and medaka (Oryzias latipes) 2026
    21. Effect of <i>Ficus carica</i> leaf extract on the gene expression of selected factors in HaCaT cells Journal of Cosmetic Dermatology · 2017 · 16 citations
    22. The slick hair coat locus maps to chromosome 20 in Senepol-derived cattle Animal Genetics · 2007 · 51 citations
    23. Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy Biomaterials · 2019 · 47 citations
    24. 5-α-Reductase type 2 deficiency: is there a genotype-phenotype correlation? A review Hormones · 2018 · 39 citations
    25. Stimuli-responsive nanoformulations for CRISPR-Cas9 genome editing Journal of Nanobiotechnology · 2022 · 7 citations
    26. 5α Reductase Deficiency—a Rare Cause of Ambiguous Genitalia and Gender Dysphoria JCEM Case Reports · 2024 · 1 citations
    27. 46, XY 5-Alpha Reductase Deficiency in a 36-Year-Old Phenotypic Female Patient AACE clinical case reports · 2022 · 1 citations
    28. Efficacy and safety of oral finasteride <i>versus</i> dutasteride in moderate-to-severe androgenetic alopecia in males based on trichoscopic and laboratory findings: a clinical comparison in Iran Journal of Dermatological Treatment · 2026
    29. SÍNDROME PÓS-FINASTERIDA E O IMPACTO DOS INIBIDORES DA 5-ALFA REDUTASE NOS EIXOS NEUROENDÓCRINO E METABÓLICO RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218 · 2026
    30. Genomic Markers and Personalized Medicine in Androgenetic Alopecia: A Comprehensive Review Cosmetics · 2024