59 citations
,
October 2012 in “Pharmaceutical Research” This study found that nanostructured lipid carriers with more soybean phosphatidylcholine provided better skin retention and follicular targeting for diphencyprone compared to other formulations and controls.
3 citations
,
August 2024 in “The Journal of Cell Biology” This study demonstrated that in live rodents, actin filaments adjust their structure to facilitate membrane transfer between cellular compartments with different biophysical properties.
January 2025 in “Open University of Cape Town (University of Cape Town)” This study found that lipids are highly correlated with hair curvature while proteins are not, reporting the largest number of hair lipids and identifying novel proteins and chaperones relating to different hair types for the first time.
23 citations
,
February 2020 in “PLOS genetics” This study found that biallelic LSS mutations lead to congenital hypotrichosis and cataracts, with each tissue-specific loss of function observed in mouse models.
6 citations
,
January 2016 in “Evidence-based complementary and alternative medicine” In this study, saw palmetto supplements showed varied effects on cell growth in vitro and did not significantly inhibit growth in the hamster flank organ model despite a notable trend.
22 citations
,
March 2007 in “European journal of pediatrics” This study found that scanning electron microscopy revealed considerable abnormalities in hair morphology in MPS I, II, IIIA, and IIIB patients, potentially related to heparan sulfate accumulation.
22 citations
,
September 2011 in “Journal of Investigative Dermatology” This study found that impaired TCF/Lef1 signaling in mice leads to significant skin barrier defects due to altered lipid metabolism and epidermal differentiation.
9 citations
,
June 2016 in “Stem cells” In this study, overexpression of secretory phospholipase A2 Group-IIA in transgenic mice led to depletion of hair follicle stem cells and increased differentiation, linked to changes in histone modifications.
20 citations
,
January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids” This review discusses lysophosphatidic acid's role in neuropathic pain and cholestatic itch, highlighting its complex signaling pathways, but reports no new clinical results.
This study explored the carbohydrate composition of plasma cell membranes in human embryonic epidermis over various gestational ages and found specific patterns that may inform future diagnostic and therapeutic approaches for dermatoses.
216 citations
,
May 2003 in “Journal of Investigative Dermatology” This study found that sebaceous-gland-derived glycerol significantly contributes to stratum corneum hydration in mice with sebaceous gland deficiencies.
July 2024 in “Journal of Investigative Dermatology”
72 citations
,
June 2001 in “Journal of Investigative Dermatology” This study suggests that S100A4 and S100A6 proteins may play key roles in activating stem cells for hair follicle regeneration in mice.
60 citations
,
March 2009 in “Dermato-Endocrinology” This review highlights recent findings on the importance of signalling pathways in sebaceous gland morphogenesis and differentiation, but reports no new clinical results.
2 citations
,
July 2012 in “PubMed” In this study, the use of internal wool lipid liposomes was shown to improve the lipid composition and increase the resistance to breaking in both untreated and chemically treated hair fibers.
October 2024 in “SPIRE - Sciences Po Institutional REpository” This study highlights that human hair follicle dermal papilla cells and glypicans play crucial roles in regulating hair follicle stem cell differentiation.
7 citations
,
February 1962 in “Experimental Biology and Medicine” This study observed that male and female epidermis differ significantly in total lipid and phospholipid levels during different stages of the hair growth cycle.
4 citations
,
July 2023 in “Analytical and Bioanalytical Chemistry”
18 citations
,
April 2014 in “Stem cells” The researchers reported that minor salivary gland stem cells exhibit stem cell characteristics and respond to tobacco-derived carcinogens, implicating the transforming growth factor beta pathway in their maintenance.
April 2023 in “Journal of Investigative Dermatology” CD206+ macrophages are crucial for hair growth in alopecia areata treatment.
26 citations
,
September 2018 in “Colloids and Surfaces B: Biointerfaces” This study reported that a novel liposomal formulation, SP-bFGF-SF-LIP, enhanced bFGF stability and skin permeability, significantly improving hair follicle recovery and wound healing in a mouse model.
18 citations
,
October 2021 in “Frontiers in Physiology” This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.
April 2017 in “Journal of Investigative Dermatology” In this study, bovine milk-derived oligosaccharides were found to increase sebocyte proliferation, lipid content, and inflammatory mediator synthesis through the mTORC1 pathway, potentially contributing to milk-based inflammation in sebocytes.
32 citations
,
January 2017 in “PLoS ONE” This study found that adiponectin significantly enhanced lipid production in human sebaceous glands and may be a potential target for treating conditions with reduced sebum production.
December 2023 in “Biological & pharmaceutical bulletin” This study found that combining lecithin reverse wormlike micelles with isopropyl myristate enhanced the skin permeability of a model hydrophilic drug, facilitated by interactions with sebum in hair follicles.
September 2023 in “Biomedicines” In this study, researchers found that subjects with clinical alopecia had significantly higher levels of squalene in their hair bulbs compared to controls, suggesting squalene as a potential metabolic and pathogenic marker for certain alopecia conditions.
2 citations
,
December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that SYP123 and VAMP727 are involved in the secretion and transport of inner cell wall components, which is crucial for hardening the root hair shank in Arabidopsis.
January 2022 in “Figshare” This study found that inhibiting autophagy in mouse preputial glands alters lipid metabolism, delays aging-related duct changes, and reduces pheromone production, indicating autophagy's critical role in gland homeostasis and cell breakdown during secretion.
84 citations
,
June 2010 in “The Plant Cell” In this study, disruptions in phospholipase A2 activity in Arabidopsis thaliana significantly impaired the plasma membrane localization of PIN proteins, affecting auxin transport and root development.
December 2021 in “Figshare” This study found that BBS7 is crucial for maintaining Shh signaling and periodontal ligament homeostasis, with occlusal hypofunction leading to its downregulation and impacting cell migration and angiogenesis.