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This review discusses the role of heparan sulfate proteoglycans in regulating stem cell fate and highlights their potential as targets for addressing hair loss, without reporting new clinical results.

This study examined the structural and biochemical mechanisms of human lipocalin prostaglandin D synthase, detailing substrate and product binding processes at the catalytic site and suggesting potential for drug delivery targeting hydrophobic molecules.

This research reports that multilamellar phospholipid liposomes showed the highest follicular penetration of a water-soluble dye in vitro compared to other cosmetic vehicles, suggesting potential benefits for enhancing hair conditioning and treating hair loss.

This study found that CD1a-restricted CD4+ T cells responsive to lysyl-phosphatidylglycerol were more frequent in the blood of atopic dermatitis patients, suggesting a potential role in the disease's Th2-mediated pathology.

This review discusses the role of lysophosphatidic acid in skin physiology and pathology, highlighting its significance in processes like wound healing and hair follicle development, but reports no new clinical findings.

This study observed that in Japanese females, hair lipid composition showed significant correlations, suggesting CH and CERs may act as a barrier against sebum-derived lipids.

This study found distinct localization patterns of S100 family proteins in hair follicles, suggesting their differential roles in normal hair follicle physiology.

This study reports a novel LC/MS method that separates and analyzes all known ceramide subclasses in human stratum corneum, identifying a new subclass, CER [EOdS], with minimal sample preparation.

Phospholipase Cδ1 is crucial for normal skin and hair development.

This study found that topically applied liposomal spherical nucleic acids targeting the IL-17 receptor could effectively reduce psoriasis severity in preclinical models.

This review discusses the use of phospholipid soft vesicle carriers to improve the delivery and therapeutic outcomes of topical treatments for various skin conditions, but reports no new clinical results.

This study found that autophagy in the preputial glands of mice plays a crucial role in regulating lipid and fatty acid metabolism, as well as pheromone production.

This article discusses the potential of phospholipase A2 inhibition as a therapeutic strategy for inflammatory skin diseases and emphasizes the need for further exploration of its role and administration methods.

In this study, ultradeformable liposomes containing Tween 20 or terpenes increased phospholipid bilayer fluidity and enhanced skin penetration of sodium fluorescein, with terpenes improving hair follicle penetration.

This study found that lipid supplementation can enhance hair growth by promoting trichogenic gene expression and proliferation of human dermal papilla cells, suggesting lipids as a potential therapeutic target for treating hair loss through HIF-1 signaling pathways.

This study examined the expression of fatty acid transporters and binding proteins in mouse sebaceous glands and found that CD36 did not affect the localization of other related molecules.

This study found that inhibiting arachidonate 12-lipoxygenase (ALOX12) may enhance hair cuticle maturation by increasing S100A3 protein citrullination and promoting cuticular differentiation in isolated human hair follicles.

This study discovered that the lipid in human hair follicles is mainly located in the hair cuticle and keratinized inner root sheath, distinct from sebaceous and epidermal lipids, suggesting a potential role as a "hair barrier.

This study investigated lipid loss in hair caused by surfactants and found that surface and internal modifications can significantly protect different lipids from depletion, with internal modification preventing 52.0 to 81.3% of lipids in certain groups.

This study found that incorporating steroid hormones into DPPC liposomes altered their physicochemical properties, including size, zeta potential, and phase transition temperatures.

This study found that MPZL3 plays a crucial role in controlling sebaceous gland size and sebocyte proliferation in mice and humans, implicating its potential involvement in skin disorders like acne and psoriasis.

In this study, lipid metabolism was found to be reduced in scalp tissues of patients with androgenetic alopecia, and lipid supplementation enhanced hair growth-related gene expression in human dermal papilla cells, suggesting a potential role for lipids in promoting hair growth through HIF-1 signaling.

This study found that lysophosphatidic acid increases mesenchymal stem cell proliferation and migration through signaling pathways and reactive oxygen species, implicating potential applications in stem cell expansion.

This study found that scanning electron microscopy revealed considerable abnormalities in hair morphology in MPS I, II, IIIA, and IIIB patients, potentially related to heparan sulfate accumulation.

This study found that cholesterol- and phospholipid-free multilamellar niosomes improved skin deposition and targeted deeper hair follicles better than hydrophobic PLGA nanoparticles for transdermal drug delivery.

This review discusses the role of LPA(3) in embryo implantation and its genetic connection with prostaglandin signaling, but reports no new clinical results.

In this review, researchers noted that liposomes, due to their ability to stabilize and target drugs, are effective carriers for treating various dermatological conditions such as acne and psoriasis when applied topically.

This study investigated the effects of pathological α-synuclein on sebaceous gland cells in Parkinson's disease, finding that α-synuclein exposure altered cellular differentiation and lipid production, suggesting a potential link between α-synuclein and lipid dysregulation in the skin of PD patients.