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    1. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group Fertility and sterility · 2011 · 1514 citations
    2. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018 · 418 citations
    3. Spatial organization within a niche as a determinant of stem-cell fate Nature · 2013 · 394 citations
    4. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity Nature Genetics · 2004 · 372 citations
    5. Spermidine/spermine-<i>N</i><sup>1</sup>-acetyltransferase: a key metabolic regulator AJP Endocrinology and Metabolism · 2008 · 305 citations
    6. Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development Science Signaling · 2013 · 277 citations
    7. Species Differences in Prostatic Steroid 5<i>α</i>-Reductases of Rat, Dog, and Human Endocrinology · 1985 · 193 citations
    8. Treatment of Hirsutism With Spironolactone JAMA · 1982 · 183 citations
    9. Comparison of flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial Fertility and Sterility · 1994 · 165 citations
    10. Splitting Hairs Cell · 1998 · 158 citations
    11. The effects of two doses of spironolactone on serum androgens and anagen hair in hirsute women Fertility and sterility · 1985 · 142 citations
    12. Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn Neuron · 2014 · 140 citations
    13. Genetically Altered Expression of Spermidine/Spermine N1-Acetyltransferase Affects Fat Metabolism in Mice via Acetyl-CoA Journal of Biological Chemistry · 2006 · 128 citations
    14. Activation of Polyamine Catabolism Profoundly Alters Tissue Polyamine Pools and Affects Hair Growth and Female Fertility in Transgenic Mice Overexpressing Spermidine/SpermineN 1-Acetyltransferase Journal of Biological Chemistry · 1997 · 124 citations
    15. A Novel Use of Spironolactone: Treatment of Hirsutism 1980 · 124 citations
    16. The Tissue-dependent Keratin 19 Gene Transcription Is Regulated by GKLF/KLF4 and Sp1 Journal of Biological Chemistry · 2000 · 119 citations
    17. Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review American Journal of Clinical Dermatology · 2017 · 117 citations
    18. Spironolactone versus placebo or in combination with steroids for hirsutism and/or acne Cochrane library · 2009 · 112 citations
    19. CHRONIC TREATMENT WITH FINASTERIDE DAILY DOES NOT AFFECT SPERMATOGENESIS OR SEMEN PRODUCTION IN YOUNG MEN The Journal of Urology · 1999 · 104 citations
    20. Oral spironolactone therapy for female patients with acne, hirsutism or androgenic alopecia British Journal of Dermatology · 1985 · 101 citations
    21. Spinal bicuculline produces hypersensitivity of dorsal horn neurons: effects of excitatory amino acid antagonists Pain · 1998 · 99 citations
    22. Comparison of Spironolactone, Flutamide, and Finasteride Efficacy in the Treatment of Hirsutism: A Randomized, Double Blind, Placebo-Controlled Trial1 The Journal of Clinical Endocrinology and Metabolism · 2000 · 94 citations
    23. Spearmint herbal tea has significant anti‐androgen effects in polycystic ovarian syndrome. a randomized controlled trial 2009 · 90 citations
    24. Follicular delivery of spironolactone via nanostructured lipid carriers for management of&nbsp;alopecia International Journal of Nanomedicine · 2014 · 89 citations
    25. <i>Pityrosporum</i> species as a cause of allergy and infection Allergy · 1999 · 89 citations
    26. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone International Journal of Dermatology · 2017 · 80 citations
    27. Side-Effects of Spironolactone Therapy in the Hirsute Woman 1988 · 80 citations
    28. Scalable production of controllable dermal papilla spheroids on PVA surfaces and the effects of spheroid size on hair follicle regeneration Biomaterials · 2012 · 78 citations
    29. Spironolactone is an Effective and Well Tolerated Systemic Antiandrogen Therapy for Hirsute Women* The Journal of Clinical Endocrinology & Metabolism · 1989 · 78 citations
    30. Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice PLoS ONE · 2013 · 76 citations