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    Glossary Sonic hedgehog

    protein crucial for tissue growth and hair follicle development

    Sonic hedgehog (SHH) is a protein that plays a crucial role in regulating the growth and development of various tissues and organs in the body, including hair follicles. It is part of the hedgehog signaling pathway, which is essential for cell differentiation and tissue patterning during embryonic development. Mutations or disruptions in the SHH pathway can lead to developmental disorders and diseases.

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    1. Targeting sonic hedgehog (shh) signaling pathways by the concentration–dependent topical resveratrol for protection from cyclophosphamide-induced alopecia in a mouse model Toxicology and Applied Pharmacology · 2025
    2. Effect of Sonic Hedgehog on the Regeneration of Epidermal Texture Patterns Biomedicines · 2022 · 6 citations
    3. Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells Cell stem cell · 2011 · 396 citations
    4. Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog Journal of Clinical Investigation · 1999 · 231 citations
    5. Hair follicles’ transit-amplifying cells govern concurrent dermal adipocyte production through Sonic Hedgehog Genes & Development · 2016 · 75 citations
    6. Overexpression of Sonic Hedgehog suppresses embryonic hair follicle morphogenesis Developmental Biology · 2003 · 53 citations
    7. Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells Cell Death and Disease · 2020 · 52 citations
    8. Effect of Adenovirus-Mediated Expression of Sonic Hedgehog Gene on Hair Regrowth in Mice With Chemotherapy-Induced Alopecia JNCI: Journal of the National Cancer Institute · 2001 · 39 citations
    9. Testing Chemotherapeutic Agents in the Feather Follicle Identifies a Selective Blockade of Cell Proliferation and a Key Role for Sonic Hedgehog Signaling in Chemotherapy-Induced Tissue Damage Journal of Investigative Dermatology · 2014 · 30 citations
    10. Sonic Hedgehog signalling in the regulation of barrier tissue homeostasis and inflammation FEBS Journal · 2021 · 23 citations
    11. Transient agonism of the sonic hedgehog pathway triggers a permanent transition of skin appendage fate in the chicken embryo Science Advances · 2023 · 18 citations
    12. Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways Frontiers in pharmacology · 2018 · 14 citations
    13. Suppression of hair follicle development inhibits induction of sonic hedgehog, patched, and patched-2 in hair germs in mice Archives of Dermatological Research · 2001 · 14 citations
    14. Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling Burns & Trauma · 2025 · 5 citations
    15. [Effect study of Sonic hedgehog overexpressed hair follicle stem cells in hair follicle regeneration]. PubMed · 2023
    16. Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner International Journal of Dermatology and Clinical Research · 2019
    17. Nε-(carboxymethyl) lysine represses hair follicle formation by inhibiting Sonic hedgehog expression in a NF-κB-independent manner Proceedings for Annual Meeting of The Japanese Pharmacological Society · 2019
    18. 708 Polycomb-mediated repression and Sonic hedgehog signaling regulate Merkel cell specification Journal of Investigative Dermatology · 2016
    19. Decision letter: Epithelial cells supply Sonic Hedgehog to the perinatal dentate gyrus via transport by platelets 2015
    20. Analysis of Sonic Hedgehog signalling pathway gene expression in Basal Cell Carcinoma and in GLII induced systems Queen Mary Research Online (Queen Mary University of London) · 2007
    21. The effects of sonic, desert and Indian hedgehog signalling in skin 2003
    22. An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasis Development · 2004 · 99 citations
    23. Hair growth-promoting effect of recombinant human sonic hedgehog proteins Biomedical dermatology · 2019 · 3 citations
    24. Hedgehog signaling is essential for normal wound healing Wound Repair and Regeneration · 2008 · 112 citations
    25. Video2_BBS7–SHH Signaling Activity Regulates Primary Cilia for Periodontal Homeostasis.MP4 Figshare · 2021
    26. Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK / STAT1 signaling pathway FEBS Open Bio · 2025
    27. Hedgehog signalling in skin development and cancer Experimental Dermatology · 2006 · 190 citations
    28. Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing Nature Communications · 2018 · 145 citations
    29. Shh maintains dermal papilla identity and hair morphogenesis via a Noggin–Shh regulatory loop Genes & Development · 2012 · 138 citations
    30. MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling Developmental Cell · 2010 · 118 citations