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Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Children, especially teenagers, can get severe SARS-CoV infection with symptoms similar to adults, but they typically recover well with supportive care.

UV radiation can help sterilize wounds and promote healing but requires careful use to avoid damaging cells.

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

Sensitive skin is often caused by nerve fibers and environmental factors, and can be managed with mild skincare and professional advice.

Conditioned media from mesenchymal stem cell cultures could be a more effective alternative for regenerative therapies, but more research is needed.

Mice studies show that Protein Phosphatase 2A is crucial for cell growth, development, and disease prevention.

Mutant mice help researchers understand hair growth and related genetic factors.

Certain types of T cells are essential for healthy skin and play a role in skin diseases, but more research is needed to improve treatments.

Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.

An imbalanced gut and lack of biotin can cause hair loss in mice.

COVID-19 can cause various skin lesions, which may result from the virus and immune response, and are not directly linked to illness severity.

Hidradenitis suppurativa is caused by genetic factors, inflammation, bacteria, hormones, and lifestyle factors like obesity and smoking.

Minoxidil and finasteride treat hair loss; more research needed for other options.

Cancer can hijack the body's cell repair system to promote tumor growth, and targeting this process may improve cancer treatments.

Stress can worsen skin conditions by affecting hormone levels and immune response.

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.

The conclusion is that individual differences in COVID-19 severity are influenced by factors like age, sex, race, and genetics, which are important for personalized medicine.

Activating Nrf2 protects human hair follicles from oxidative stress and helps prevent hair growth inhibition.

Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

Prolactin may play a significant role in skin and hair health and could be a target for treating skin and hair disorders.

Pitx2 helps outer root sheath cells differentiate but can't start hair growth on its own.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.