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This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.

This review discusses transdermal drug delivery using hydrogel-forming microneedles and highlights their potential for disease treatment, but notes challenges in their clinical application.

This review discusses the unique advantages and challenges of microneedle arrays for vaccine and immunotherapy delivery but reports no new clinical results.

In this study, the combination of ECM-C with microneedle and radiofrequency treatments improved periorbital wrinkles, skin elasticity, and thickness more effectively than ECM-C with microneedles alone, but subjective evaluations showed no significant differences.

This study reported the development of a workflow that combines SIMS and X-ray elemental mapping techniques for multimodal imaging at the single cell level, successfully applied to visualize elements, metals, and lipids in porcine skin without loss or delocalization.

Using Indian marking nut sap for hair loss caused a skin rash on a woman's face.

This study found that fractional Er:YAG laser combined with platelet-rich plasma resulted in greater skin repigmentation in patients with localized stable vitiligo compared to microneedling with platelet-rich plasma, with fewer side effects reported in the laser group.

This study reports that a novel ketoconazole-loaded microneedle array significantly enhances drug delivery and retention in the skin, demonstrating improved hair growth in animal models, suggesting a promising treatment for androgenic alopecia that addresses current topical therapies' limitations.

This chapter provides an overview of phytochemicals with properties to combat alopecia and discusses the potential of flavonoids, found in several herbs, as a safer alternative to synthetic hair loss treatments due to their long-term skin compatibility.

Surgical hair restoration has improved since 1959, with new techniques like minigrafts, micrografts, and scalp reductions creating more natural hairlines and reducing bald skin, despite some risks and potential for scarring.

This study reports a case of Indralupta (Alopecia Areata) successfully treated using Ayurvedic methods including Prachhan karma, Lepa, and Shirodhara, offering an alternative to conventional treatments like minoxidil and steroids, which may have adverse effects.

This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.

This study found that mange was the most common cause of alopecia in dogs, with cases being more prevalent during the summer and among dogs less than one year old.

This review discusses various treatments for noncicatricial alopecias, such as androgenetic alopecia and alopecia areata, including mesotherapy, microneedling, and platelet-rich plasma therapy, noting that outcomes vary across these procedures.

This review discusses the expanding role of microneedling in dermatology, highlighting its enhanced effectiveness when combined with other treatments like minoxidil, platelet-rich plasma, and exosomes, but reports no clinical results.

Cold gel compresses are the best for pain relief during scalp microneedling.

This review details the evolution of hair treatment techniques, focusing on the application of microneedling for hair stimulation and drug delivery, but offers no new clinical findings.

This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.

This study found that permanent makeup pigments were applied at similar depths as traditional tattoo inks in mice but faded over time due to larger inorganic pigments.

This study reports that hair follicle neural crest stem cells in mice can be differentiated into melanocytes, potentially aiding repigmentation in vitiligo-affected areas.

This study found that a microneedle system delivering VEGF and Ritlecitinib improved hair regeneration in mice with androgenetic alopecia, showing faster anagen onset and better hair quality compared to minoxidil.

The Dfl mutation in mice causes poor sebaceous gland function and complete hair loss.

This study developed the TLMG hydrogel, a seamless in situ biointerface platform, demonstrating robust adhesion, high conductivity, and therapeutic effects for intelligent wound management in complex animal models and human tests, indicating its promise for integrated bioelectronic medicine.

This study retrospectively observed that combining microneedle minoxidil with triamcinolone acetonide showed clinical efficacy in treating alopecia areata, a condition marked by sudden patchy hair loss.

This study found that platelet rich plasma (PRP) is a safe and effective treatment for alopecia areata, with no significant difference in efficacy between activated and non-activated PRP.

This review discusses the use of microneedling for androgenetic alopecia and finds it promising for enhancing hair density and thickness, especially when combined with other treatments, but notes no standardized protocol exists yet.

This review suggests that microneedling shows promise for improving hair quality, thickness, and density in treating androgenetic alopecia, but standardized treatment protocols are currently lacking.

The microneedle arrays effectively promote wound healing and have potential for clinical use.

This study conducted in a hair restoration clinic found that using the vertical scalp mobility method resulted in a significantly greater number of hairs available from the donor strip compared to the horizontal method, with an increase of approximately 970 hairs (P < .05).

This study reports that while both dermaroller and fractional CO2 laser treatments for acne can lead to hyperpigmentation, itching was specifically noted only after fractional CO2 laser treatment.