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    Glossary Skin Fibrosis

    excessive fibrous tissue buildup in skin causing thickening

    Skin fibrosis, also known as dermal fibrosis, is a condition characterized by the excessive accumulation of fibrous connective tissue in the skin. This can result from chronic inflammation, injury, or diseases such as scleroderma. The overproduction of collagen leads to thickening, hardening, and scarring of the skin, which can impair its normal function and elasticity.

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    1. MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment Molecular diagnosis & therapy · 2017 · 32 citations
    2. miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades Journal of Advanced Research · 2024 · 15 citations
    3. ACKR2 limits skin fibrosis and hair loss through IFN‐β The FASEB Journal · 2021 · 10 citations
    4. [Expressions and effects of autophagy-related genes in bleomycin-induced skin fibrosis of mice]. PubMed · 2020 · 1 citations
    5. Radiotherapy-Induced Skin Fibrosis: Pathophysiology, Emerging Therapeutics, and the Role of Dermatology American Journal of Clinical Dermatology · 2026
    6. [Influence and mechanism of extracellular vesicles derived from human dermal papilla cells on skin fibrosis in mice]. PubMed · 2025
    7. [Effect of deep dermal tissue dislocation injury on skin fibrosis in pig]. PubMed · 2022
    8. 612 Wnt signaling induces fibrotic fat loss via DPP4 in skin fibrosis Journal of Investigative Dermatology · 2021
    9. 270 A novel small compound HPH-15 antagonizes TGF-β/Smad signaling and ameliorates experimental skin fibrosis Journal of Investigative Dermatology · 2017
    10. Frontal Fibrosing Alopecia. An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin? Clinical, cosmetic and investigational dermatology · 2020 · 8 citations
    11. Dermal white adipose tissue: Development and impact on hair follicles, skin defense, and fibrosis The FASEB Journal · 2024 · 3 citations
    12. Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling Cell Reports Medicine · 2026
    13. Tissue engineering strategies combining molecular targets against inflammation and fibrosis, and umbilical cord blood stem cells to improve hampered muscle and skin regeneration following cleft repair Medicinal Research Reviews · 2019 · 30 citations
    14. 1493 Dynamic changes in fibroblast subpopulations drives development of radiation-induced skin fibrosis through the fra/c-jun pathway Journal of Investigative Dermatology · 2023
    15. Overexpression of activin A in the skin of transgenic mice reveals new activities of activin in epidermal morphogenesis, dermal fibrosis and wound repair EMBO journal · 1999 · 204 citations
    16. TGFβ‐mediated inhibition of hypodermal adipocyte progenitor differentiation promotes wound‐induced skin fibrosis Cell Proliferation · 2024 · 3 citations
    17. Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis 2024
    18. Isolated Human Skin Glands and Appendages: Models for Cystic Fibrosis, Acne Vulgaris, Alopecia and Hidradenitis Suppurativa 1990
    19. Frontal Fibrosing Alopecia. An Example of Disrupted Aryl Hydrocarbon Receptor-Mediated Immunological Homeostasis in the Skin? DOAJ (DOAJ: Directory of Open Access Journals) · 2020
    20. Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways Cell Proliferation · 2025
    21. Regenerative Medicine to Reduce the Side Effects from Radiotherapy Causing Skin Cancer, Fibrosis, Neuropathic Pain and Hair Loss Journal of Cancer Therapy · 2021 · 1 citations
    22. Mesenchymal Stromal Cell-Conditioned Medium for Skin Diseases: A Systematic Review Frontiers in Cell and Developmental Biology · 2021 · 26 citations
    23. Accelerated senescence in skin in a murine model of radiation-induced multi-organ injury Journal of radiation research · 2017 · 19 citations
    24. Clinical, mechanistic, and therapeutic landscape of cutaneous fibrosis Science Translational Medicine · 2024 · 16 citations
    25. Therapeutic potential of endogenous stem cells and cellular factors for scar-free skin regeneration Drug Discovery Today · 2018 · 9 citations
    26. Tissue fibrosis associated depletion of lipid‐filled cells Experimental Dermatology · 2024 · 6 citations
    27. Bee venom: a case of effectiveness on skin varicosities veins with review of its dermatological benefits 2020 · 1 citations
    28. Dermal Fibrosis and the Current Scope of Hydrogel Strategies for Scarless Wound Healing Fibrosis · 2024 · 1 citations
    29. The Impact of LED Therapy on Skin: The Review Journal of Education Health and Sport · 2025
    30. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025