96 citations
,
January 1997 in “Clinics in Dermatology” This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
71 citations
,
February 2006 in “Clinics in Dermatology” This review discusses the physiological skin changes during pregnancy and reports no new clinical results, emphasizing the importance of distinguishing these changes from pathological conditions.
4 citations
,
October 2005 in “Pediatric Transplantation” This study identified that pediatric transplant recipients experience specific skin changes related to medication use, with unique conditions like ichthyosiform xerosis in kidney recipients and skin scaling with pellagroid appearance in bone marrow recipients.
3 citations
,
January 2018 in “Indian Dermatology Online Journal” This study found that normal physiological cutaneous changes were the most common skin changes during pregnancy in Northeast India, while specific dermatoses were rare and not significantly influenced by ethnicity or geography.
3 citations
,
June 1981 in “PubMed” This article reviews the skin changes that can occur with hormonal contraceptive use and highlights various mechanisms and potential treatment strategies but reports no new clinical results.
1 citations
,
January 2024 in “The Journal of Dermatology” In this study, Asian breast cancer patients undergoing taxane-based chemotherapy in the adjuvant treatment group reported significantly increased hair loss, higher melanin index, and more wrinkles compared to other treatments, while most neoadjuvant group patients saw hair loss reversed six months post-surgery.
June 2026 in “Reports of Morphology” This study on female Wistar rats with stress-induced alopecia found that a modified diet rich in antioxidants and nutrients reduced dystrophic skin changes and preserved the functional activity of hair follicles, suggesting dietary approaches may support hair restoration under chronic stress conditions.
In this chapter, the authors discuss how the decline in estrogen during menopause affects skin health, detailing changes like dryness, thinning, and increased sensitivity, and suggest management strategies such as lifestyle adjustments and hormone replacement therapy to address these issues.
January 2023 in “Indian journal of pharmacy practice” This study observed that dermoscopic features of skin affected by topical corticosteroids and hydroquinone correlated with histopathological changes, highlighting the importance of awareness regarding their long-term adverse effects.
October 1933 in “Experimental Biology and Medicine” In this study, subcutaneous injections of epinephrine in rats led to skin changes ranging from hair loss to necrosis, suggesting these effects were due to the epinephrine itself.
December 2022 in “Gastroenterology” This report describes a case of Cronkhite-Canada syndrome diagnosed in a 54-year-old man with symptoms including gastrointestinal polyps, alopecia, skin hyperpigmentation, and severe diarrhea, who experienced significant symptom improvement with azathioprine.
18 citations
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September 1990 in “Veterinary Dermatology” This study in SPF lambs found that primary and secondary orf virus infections trigger similar skin responses, but the primary infection caused a more severe and prolonged reaction.
141 citations
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January 1984 in “Journal of The American Academy of Dermatology” This review discusses skin changes during pregnancy, highlighting both pregnancy-specific and common physiologic changes, but reports no new clinical findings.
64 citations
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June 1992 in “International Journal of Dermatology” Pregnancy often causes skin changes like darkening, stretch marks, and hair growth, which may improve after childbirth.
19 citations
,
July 1993 in “Journal of Applied Toxicology” This study found that various petroleum distillates caused significant skin changes in mice, with severity varying based on the product and penetration pathway, potentially leading to skin tumors through non-genotoxic mechanisms in longer-term exposure.
2 citations
,
July 2024 in “International Journal of Cosmetic Science” In this study, researchers found that differences between self-ratings and assessor ratings of facial appearance vary by age and ethnicity, and these discrepancies, along with assessor ratings of skin features, are predictive of menopausal status across ethnic groups.
July 2025 in “BMC Microbiology” This study observed that pancreatic cancer-related skin lesions in mice are linked to microbiota imbalances, specifically noting changes in the abundance of certain bacterial genera, which may offer potential diagnostic or therapeutic targets for managing skin complications in humans with pancreatic cancer.
40 citations
,
July 2013 in “Skin Pharmacology and Physiology” This study reports that among men, skin surface hydration and pH change with age, but transepidermal water loss and sebum production show less variation.
11 citations
,
March 2018 in “Journal of cosmetic and laser therapy” In this study, pneumatic injections of non-cross-linked hyaluronic acid were associated with improvements in skin texture, pores, wrinkles, and transepidermal water loss in healthy female volunteers.
6 citations
,
January 2016 in “Journal of Biomedical Photonics & Engineering” This study found that using a clipping device for hair removal leads to less skin barrier disruption and reduced bacterial colonization compared to a disposable razor, potentially improving postoperative wound management.
4 citations
,
May 2023 in “Plastic & Reconstructive Surgery” This study found that transplanting adipose tissue into the rat dorsum supported long-term skin expansion by enhancing thickness, vascularization, and cell proliferation, with adipose-derived cells actively contributing to skin regeneration and growth factor expression.
35 citations
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December 2014 in “Clinical Obstetrics and Gynecology” This article discusses skin changes during pregnancy and emphasizes the importance of recognizing these physiological manifestations to prevent unnecessary tests and stress for pregnant patients; it reports no new study findings.
19 citations
,
January 2015 in “Indian Journal of Dermatology” In this study, researchers observed that 90% of patients with PCOS had cutaneous manifestations, with acne most common, and found associations between these skin conditions and high insulin or testosterone levels.
14 citations
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June 2020 in “BMC genomics” This study observed that the growth cycle of cashmere in Inner Mongolian cashmere goats consists of three phases, with genes KAP3–1, KRTAP 8–1, and KRTAP 24–1 closely correlating with this cycle.
6 citations
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January 1967 in “Journal of Small Animal Practice” This study observed that aged dogs exhibit atrophy of the epidermis, appendages, and dermis, along with variable skin changes and increased dermal pigmentation, but lack senile elastosis seen in humans.
4 citations
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August 2025 in “Journal of Cosmetic Dermatology” This study found that while hormone replacement therapy can improve skin aging in menopausal women, inconsistent findings and a lack of robust clinical trials mean it isn't recommended purely for skin benefits.
2 citations
,
December 2019 in “Electronic Journal of General Medicine” This study found that combining microfocused ultrasound with autologous blood cell factors significantly improved skin rejuvenation compared to using microfocused ultrasound alone.
2 citations
,
June 2013 in “Journal of Clinical Pathology” This article reviews the role of LMNA gene mutations, particularly in Hutchinson–Gilford progeria syndrome, but does not report new experimental findings.
1 citations
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August 2019 in “Research Square (Research Square)” In this study, researchers found that the cashmere hair growth cycle is divided into three periods and key genes like KAP and KRTAP are positively correlated with these cycles in cashmere goats.
1 citations
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April 2018 in “Journal of dairy science” This study observed that hair follicle morphology in dairy cows changes during the peripartum period, with fluctuations in hair follicle width and anagen percentage but no overall marked changes in skin morphology parameters.