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    Glossary Skin Barrier Dysfunction

    Skin barrier dysfunction refers to the impaired ability of the skin to act as a protective barrier, which can lead to increased transepidermal water loss and susceptibility to irritants, allergens, and pathogens. In the context of hair loss, a compromised skin barrier can affect the scalp's health, potentially leading to inflammation and conditions such as seborrheic dermatitis or psoriasis, which may contribute to hair thinning or loss. Key distinguishing characteristics include alterations in skin hydration, texture, and the presence of inflammatory markers, which can impact hair follicle function and overall hair growth.

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    1. Skin Barrier Dysfunction in Acne Vulgaris: Pathogenesis and Therapeutic Approaches Medical Science Monitor · 2024 · 18 citations
    2. Homozygous ALOXE3 Nonsense Variant Identified in a Patient with Non-Bullous Congenital Ichthyosiform Erythroderma Complicated by Superimposed Bullous Majocchi’s Granuloma: The Consequences of Skin Barrier Dysfunction International Journal of Molecular Sciences · 2015 · 16 citations
    3. Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction Journal of Cell Science · 2009 · 87 citations
    4. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    5. Skin aging and barrier dysfunction: bridging current therapies with future genetic and nanotechnological interventions Aesthetic Cosmetology and Medicine · 2026
    6. Hypothesis: platelet-rich plasma as an adjunct therapy for eczema targeting inflammation, skin barrier repair, and chronic recurrence Frontiers in Immunology · 2025
    7. Hidradenitis suppurativa: A folliculotropic disease of innate immune barrier dysfunction? Experimental dermatology · 2021 · 9 citations
    8. Histologic morphology and involucrin, filaggrin, and keratin expression in normal canine skin from dogs of different breeds and coat types Journal of Veterinary Science · 2012 · 15 citations
    9. Radiation Dermatitis: Radiation-Induced Effects on the Structural and Immunological Barrier Function of the Epidermis International journal of molecular sciences · 2024 · 1 citations
    10. Understanding the Impact of the Skin Microbiome on Dermatological Assessments and Therapeutic Innovation Dermato · 2025
    11. IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model mice Research Square (Research Square) · 2023
    12. 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function 2018
    13. Hair follicle stem cells and the collapse of self-tolerance in alopecia: the interplay of barrier function, the microbiome, and immunity EMBO Molecular Medicine · 2024
    14. <i>Malassezia</i> and the Asian menopausal skin 2025
    15. Research Progress of Skin Barrier and Acne International Journal of Health and Pharmaceutical Medicine · 2023 · 1 citations
    16. Granzyme B in Autoimmune Skin Disease Biomolecules · 2023 · 35 citations
    17. Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model Barrier Immunity · 2025 · 1 citations
    18. Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes Journal of Biomedical Science · 2025 · 7 citations
    19. Genomic and phenotypic characterization of Investigator Global Assessment (IGA) scale-based endotypes in atopic dermatitis Journal of The American Academy of Dermatology · 2021 · 3 citations
    20. The Pilocutaneous Syndrome of Menopause Figshare · 2026
    21. The Pilocutaneous Syndrome of Menopause Figshare · 2026
    22. Contact sensitization to hair care allergens in scalp seborrheic dermatitis: associations with disease severity and microbiota profiles Frontiers in Allergy · 2026
    23. Cutaneous Manifestations of Chronic Kidney Disease: A Narrative Review Journal of Biosciences and Medicines · 2026
    24. Controversial issues of hyperinfestation with Demodex mites in rosacea and acne Meditsinskiy sovet = Medical Council · 2025
    25. Evaluation of clinical and lifestyle factors associated with disease severity in adult patients with scalp seborrheic dermatitis DiRROS repository (University of Maribor) · 2025
    26. Netherton Syndrome: A Case-Based Review of Diagnosis, Management, and Emerging Treatments. PubMed · 2025
    27. 176 Hair eruption initiates adverse events of EGFR-targeted cancer therapy Journal of Investigative Dermatology · 2023
    28. The genetic basis of dermatophytosis skin infection susceptibility Nature Communications · 2026
    29. Skin-associated adipocytes in skin barrier immunity: A mini-review Frontiers in Immunology · 2023 · 20 citations
    30. Skin barrier, phenotypic and genotypic characterisation of autosomal recessive ichthyosis in TGM1‐deficient Jack Russell Terriers and response to topical ceramide Veterinary Dermatology · 2024