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    Glossary Skin Atrophy

    thinning of skin layers, increasing fragility and transparency

    Skin atrophy, also known as skin thinning or dermal atrophy, refers to the thinning of the skin layers, including the epidermis and dermis. This condition can result from aging, prolonged use of topical corticosteroids, or certain medical conditions, leading to increased fragility, transparency, and a higher risk of injury or tearing.

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    1. Hyaluronate Fragments Reverse Skin Atrophy by a CD44-Dependent Mechanism PLoS Medicine · 2006 · 135 citations
    2. Skin physiology in microgravity: a 3-month stay aboard ISS induces dermal atrophy and affects cutaneous muscle and hair follicles cycling in mice NPJ microgravity · 2015 · 48 citations
    3. Perilymphatic Atrophy of the Skin Archives of Dermatology · 1975 · 25 citations
    4. Targeted Skin Overexpression of the Mineralocorticoid Receptor in Mice Causes Epidermal Atrophy, Premature Skin Barrier Formation, Eye Abnormalities, and Alopecia American Journal of Pathology · 2007 · 67 citations
    5. Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands 2013 · 25 citations
    6. Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse Toxicologic pathology · 2014 · 6 citations
    7. Localised Skin Hyperpigmentation as a Presenting Symptom of Vitamin B12 Deficiency Complicating Chronic Atrophic Gastritis Sultan Qaboos University medical journal · 2015 · 5 citations
    8. Faculty Opinions recommendation of Targeted skin overexpression of the mineralocorticoid receptor in mice causes epidermal atrophy, premature skin barrier formation, eye abnormalities, and alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2007
    9. The mineralocorticoid receptor as a novel player in skin biology: beyond the renal horizon? Experimental Dermatology · 2009 · 40 citations
    10. Dorsal Skin Reactions of Hairless Dogs to Topical Treatment with Corticosteroids Toxicologic pathology · 1999 · 36 citations
    11. Skin Academy: Hair, skin, hormones and menopause – current status/knowledge on the management of hair disorders in menopausal women European Journal of Dermatology · 2012 · 31 citations
    12. Finasteride-mediated hair regrowth and reversal of atrophy in a patient with frontal fibrosing alopecia JAAD case reports · 2015 · 24 citations
    13. Thyroid hormone action on skin. PubMed · 2011 · 24 citations
    14. Epithelial Cells in the Hair Follicle Bulge do not Contribute to Epidermal Regeneration after Glucocorticoid-Induced Cutaneous Atrophy 2007 · 23 citations
    15. Dermatitis cruris pustulosa et atrophicans revisited: our experience with 37 patients in south India International Journal of Dermatology · 2009 · 14 citations
    16. Trichoscopy of Steroid-Induced Atrophy Skin Appendage Disorders · 2017 · 11 citations
    17. A novel actor in skin biology: the mineralocorticoid receptor Experimental dermatology · 2015 · 7 citations
    18. Effects of Adipose-Derived Stem Cells and Platelet-Rich Plasma for Prevention of Alopecia and Other Skin Complications of Radiotherapy Annals of Plastic Surgery · 2020 · 6 citations
    19. Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System Pharmaceutics · 2023 · 2 citations
    20. Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i> bioRxiv (Cold Spring Harbor Laboratory) · 2026
    21. Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling Cell Reports Medicine · 2026
    22. SP0011 Long-Term Glucocorticoid Use and The Skin Annals of the Rheumatic Diseases · 2016
    23. The Skin at Different Ages 2014
    24. Role of Stearoyl-CoA Desaturase-1 in Skin Integrity and Whole Body Energy Balance Journal of Biological Chemistry · 2013 · 67 citations
    25. Functional analysis of the stratum corneum of scalp skin: studies in patients with alopecia areata and androgenetic alopecia Archives of Dermatological Research · 2000 · 52 citations
    26. Cutaneous Atrophy and Alopecia After Greater Occipital Nerve Injection Using Triamcinolone Headache The Journal of Head and Face Pain · 2012 · 39 citations
    27. Corticosteroid Atrophy Plaque on the Scalp Treated with 5-Fluourouracil and Bleomycin Infusion in the MMP Technique Skin Appendage Disorders · 2024 · 1 citations
    28. Morphological changes in the skin in a rat model of stress-induced alopecia and their correction with nutrients Reports of Morphology · 2026
    29. Skin Changes on the Face Caused by Over-the-counter Cosmetic Creams: An Observational Study of Clinical and Dermoscopy Features Indian journal of pharmacy practice · 2023
    30. The Effect of Hairless Mutant Gene on The Thymus and Skin Under The C_(57)BL/6 Genetic Background Laboratory Animal Science and Administration · 2004