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    Glossary Signal Transducer and Activator of Transcription 3

    protein involved in cell signaling and gene expression regulation

    Signal Transducer and Activator of Transcription 3 (STAT3) is a protein that plays a crucial role in cell signaling, helping to transmit signals from the cell surface to the nucleus. It is involved in various cellular processes, including growth, survival, and immune response. When activated, STAT3 can promote the expression of specific genes that drive these processes, and its dysregulation is often linked to diseases such as cancer and inflammatory conditions.

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    1. Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A case control study Skin Pharmacology and Physiology · 2022
    2. Signal transducer and activator of transcription 5B deficiency due to a novel missense mutation in the coiled-coil domain 2018 · 14 citations
    3. IN-SILICO STUDY OF BIOACTIVE COMPOUNDS OF NATURAL MATERIALS AS A JAK- SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION INHIBITOR FOR ANTI-ALOPECIA Asian journal of pharmaceutical and clinical research · 2017
    4. The JAK/STAT signaling pathway: from bench to clinic Signal Transduction and Targeted Therapy · 2021 · 489 citations
    5. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
    6. Two distinct signaling pathways in hair cycle induction: Stat3-dependent and -independent pathways Proceedings of the National Academy of Sciences of the United States of America · 2000 · 73 citations
    7. ROS-responsive hydrogel-delivered miR-665 targets STAT3 to alleviate inflammation and promote hair follicle regeneration in alopecia areata Journal of Nanobiotechnology · 2026
    8. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    9. Abstract 152 Plastic and Reconstructive Surgery · 2015
    10. JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia EMBO Molecular Medicine · 2024 · 8 citations
    11. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations
    12. 0975 Single-cell transcriptomic profiling reveals distinct immunopathogenic programs in alopecia totalis/universalis compared to patchy alopecia areata Journal of Investigative Dermatology · 2026
    13. New Treatment Strategies in Management of Alopecia Areata: Review Article The Egyptian Journal of Hospital Medicine · 2023
    14. Topical metformin as a novel therapy for alopecia areata due to its immunologic effects Medical Hypotheses · 2023
    15. Baricitinib-Induced Trichilemmal Cyst Reactivation in a Woman With Alopecia Areata Cutis · 2025
    16. 59 Scarring alopecia is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege 2023
    17. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    18. JAK-inhibitors. New players in the field of immune-mediated diseases, beyond rheumatoid arthritis Rheumatology · 2018 · 223 citations
    19. Inhibidores de JAK: usos en dermatología. Parte 1: generalidades, aplicaciones en vitíligo y en alopecia areata Actas Dermo-Sifiliográficas · 2020 · 20 citations
    20. Langerin+ Dendritic Cells in Cutaneous Fibrosis: The TGF-β1 Signaling Axis Clinical Cosmetic and Investigational Dermatology · 2025
    21. STAT3 Inhibits Cell Proliferation at Least in Part Via Directly Negatively Regulating FST Gene Expression Research Square (Research Square) · 2021
    22. H2AK119ub dynamics control hair follicle stem cell quiescence Nature Communications · 2025 · 2 citations
    23. GLI2-specific Transcriptional Activation of the Bone Morphogenetic Protein/Activin Antagonist Follistatin in Human Epidermal Cells 2008 · 39 citations
    24. Decision letter: Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis 2022
    25. Progenitor Cell Dynamics in Androgenetic Alopecia: Insights from Spatially Resolved Transcriptomics International Journal of Molecular Sciences · 2025
    26. A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle Journal of Molecular Cell Biology · 2018 · 26 citations
    27. In vivo transcriptional governance of hair follicle stem cells by canonical Wnt regulators Nature Cell Biology · 2014 · 173 citations
    28. Distinct tooth regeneration systems deploy a conserved battery of genes bioRxiv (Cold Spring Harbor Laboratory) · 2020
    29. Interleukin-1 Induces Transcription of Keratin K6 in Human Epidermal Keratinocytes 2001 · 90 citations
    30. Physical and Functional Interaction between the Vitamin D Receptor and Hairless Corepressor, Two Proteins Required for Hair Cycling Journal of Biological Chemistry · 2003 · 215 citations