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The guideline provides healthcare professionals in South Africa with instructions for comprehensive, multidisciplinary gender-affirming care, including HIV prevention and treatment for transgender and gender diverse individuals.

This study found that α-ketoglutarate protected dermal papilla cells from oxidative stress by enhancing the Nrf2 pathway and mitigating cell damage through the ERK/Nrf2 axis.

This review highlights potential negative impacts of certain medications on male fertility, such as hormonal disruption and germ cell toxicity, emphasizing the importance of clinicians being aware of these effects to advise on safer alternatives.

This review discusses the association between emotional stress-related neuropeptides and the pathogenesis of alopecia areata, reporting no new experimental findings.

This article reviews the immunometabolic mechanisms linking polycystic ovary syndrome to infertility and stresses the need for interdisciplinary approaches to treat PCOS-related fertility issues; it reports no new clinical results.

This study suggests that the CXCL8 gene may regulate cashmere fineness in Liaoning cashmere goats, providing new insights into the cellular mechanisms of cashmere growth and quality.

This review critically evaluates the evidence for SARMs' tissue selectivity and suggests their clinical benefits over traditional androgens are not yet well-supported by robust evidence, underscoring the need for further head-to-head trials.

This study found that women with PCOS had significantly higher levels of several autoantibodies compared to healthy controls, suggesting a potential autoimmune component to PCOS that might aid in better disease characterization and personalized management.

This review article summarizes recent advancements in biomimetic scaffolds, highlighting their promise in tissue engineering and personalized medicine, particularly for skin and musculoskeletal system regeneration, while emphasizing the need for more extensive research to ensure their safety for human use.

This study observed that numerical chromosomal aberrations were more common in men with severe male factor infertility and azoospermia compared to those with other sperm quality issues, while chromosomal translocations were significantly associated with oligoasthenozoospermia, highlighting important genetic counseling considerations.

This review outlines the design and engineering of multifunctional hydrogels, emphasizing their evolving biomedical applications, notably in controlled drug delivery, tissue support, and disease management, and discusses their potential for clinical translation.

This review summarizes how single-cell omics technologies have advanced understanding of cellular regulatory programs in sheep and goats, but highlights limitations in genomic annotation and integration with population genetics for molecular breeding.

In this study, researchers did not find any genome-wide significant genetic signals linked to comorbid chronic inflammatory disorders in patients with alopecia areata, but exploratory analysis suggested potential associations worth further study.

In this preclinical study, PA-011 derived from Periplaneta americana showed significant hair regrowth effects in androgenetic alopecia mouse models by inhibiting inflammation and oxidative stress, activating hair follicle stem cell proliferation, and normalizing skin microbiota, suggesting promise as an AGA treatment.

This review explores the hormonal factors linking polycystic ovary syndrome and psychiatric disorders, such as eating disorders, emphasizing a bidirectional relationship that necessitates a multidisciplinary treatment approach; it reports no new clinical results.

This study found that external and internal luteolin treatments reduced hair graying in model mice by mitigating age-related dysfunction in hair stem cell signaling, suggesting potential practical applications for anti-graying treatment in humans.

This study highlights a close link between metabolic syndrome, characterized by conditions like obesity and hypertension, and various inflammatory skin diseases, suggesting that mitochondrial dysfunction plays a key role in their pathogenesis and could be a target for new therapies.

This study updates guidelines for evaluating and managing male infertility, including revised testing recommendations for Y-chromosome microdeletions, use of pelvic MRI, and testicular sperm in nonazoospermic males.

This review discusses various potential risk factors and possible therapeutic interventions for polycystic ovary syndrome, including the modulation of gut microbiota, but reports no new findings.

This review discusses recurrent implantation failure (RIF) in IVF, noting the lack of standard definitions or treatment protocols, and emphasizes the need for individualized treatment and further research.

This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.

This review discusses the commonly observed pathological findings in progeroid mouse models and highlights the importance of understanding mouse strain backgrounds and progeria-related phenotypes for accurate pathology data interpretation.

This review summarizes factors involved in polycystic ovary syndrome pathogenesis and management, highlights commonly prescribed and repurposed medications, and calls for well-designed clinical trials to evaluate these treatments further.

HDAC1 is crucial for skin development and preventing tumors.

Protein ubiquitylation is crucial for controlling stem cell functions and could be targeted for cancer treatment.

In this study, transgenic mice expressing Msx-2 developed flaky skin with hyperproliferation and misalignment in epidermal cells, suggesting Msx-2 plays a role in skin and appendage growth control.

This study found that although progerin expression in mouse skin causes significant nuclear shape changes in keratinocytes, it does not result in alopecia or common skin abnormalities seen in human Hutchinson–Gilford progeria syndrome.

This study proposes reclassifying PCOS into two distinct phenotypes based on androgen levels and suggests androgen supplementation may overcome IVF resistance in one group with advancing age.

mTORC2 is crucial for healthy skin barrier by regulating lipids and filaggrin.

In this review, researchers reported that cinnamon and ginger supplementation may benefit PCOS patients by improving hormonal status, lipid profiles, obesity, and insulin resistance through oxidative stress and inflammation reduction.