24 citations
,
June 2015 in “Journal of Investigative Dermatology” This study observed that epidermal-specific deletion of aPKCλ in mice disrupts hair follicle stem cell quiescence, leading to altered hair follicle cycling and skin anomalies.
21 citations
,
July 2022 in “Orphanet journal of rare diseases” This review discusses recent advancements in therapies for ichthyosis, highlighting promising prospects in protein replacement and gene therapy, but it reports no new clinical results.
21 citations
,
November 2019 in “Molecular & Cellular Proteomics” This study found that citrullinated proteins, which are implicated in rheumatoid arthritis, were abundant in outer membrane vesicles from Porphyromonas gingivalis but nearly absent in mutants, validating their approach to citrullinated peptide identification.
19 citations
,
January 2023 in “Genes” This study identified genomic regions and genes associated with wool, live weight, body condition, and reproduction traits in Uruguayan Merino sheep, highlighting potential genetic factors influencing these characteristics.
19 citations
,
March 2022 in “International Journal of Environmental Research and Public Health” This review covers the neuroendocrine aspects of polycystic ovary syndrome, focusing on hormones and neurotransmitters like GnRH and kisspeptin, but does not report new clinical findings.
19 citations
,
January 2019 in “Molecular Medicine Reports” This study found that for optimal ADSC viability during short-term storage, using 10% human serum at 4°C and utilizing the cells within 2 hours is most effective.
18 citations
,
October 2022 in “Biomedicines” This review discusses the role of anti-Müllerian hormone in polycystic ovary syndrome and its male equivalent, but reports no new clinical findings; it suggests further investigation is needed into male relatives' reproductive function.
15 citations
,
June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.
15 citations
,
February 2020 in “Journal of Investigative Dermatology” Ceramide Synthase 4 is crucial for healthy skin barrier function.
15 citations
,
September 2002 in “Journal of Biological Chemistry” This study observed that transgenic mice expressing keratin K10 under bovine K6beta control developed severe oral abnormalities, suggesting keratin composition changes can affect the physiology of epithelial cells, especially in the oral mucosa.
14 citations
,
November 2022 in “Development” This review discusses how transposable element activation may hinder tissue regeneration and explores mechanisms to control this activity, reporting no new experimental results.
14 citations
,
May 2016 in “International Journal of Molecular Sciences” This study showed that knocking out the Ppp2ca gene in the epidermis of mice led to significant hair loss and disrupted hair follicle morphogenesis and regeneration.
13 citations
,
February 2023 in “Biology” This review highlights the potential of cell-free therapies, particularly cell extracts, in addressing radiation-induced salivary gland damage from head and neck cancer treatment, emphasizing their practicality and safety compared to traditional therapies despite incomplete understanding of their bioactive components.
12 citations
,
November 2024 in “Journal of Ovarian Research” This study found that interleukin-1-alpha and oncostatin-M levels were positively associated with PCOS development, while interleukin-7, IL15RA, and CXCL11 were negatively associated, suggesting a connection between inflammatory factors and PCOS.
11 citations
,
April 2013 in “Hormones” This article reviews recent data suggesting that metformin may be beneficial for anovulatory PCOS patients with normal BMI and clomiphene resistance but emphasizes that more studies are needed to confirm these findings.
10 citations
,
August 2023 in “Advanced Science” This review discusses nitric oxide's physiological roles and the development of strategies for delivering it exogenously, without presenting new clinical results.
10 citations
,
June 2022 in “Development” This study suggests that distinct chromatin topologies allow different lineage-specific enhancers to regulate Hoxd genes in mouse vibrissae and chicken feather primordia, while conserved regulatory elements maintain transcriptional robustness in the embryonic trunk across species.
10 citations
,
August 2021 in “EMBO Reports” This study found that the anti-apoptotic Bcl-2 protein plays a crucial role in maintaining hair follicle stem cell function and influences tissue regeneration and tumor formation in mice.
9 citations
,
July 2022 in “International Journal of Molecular Sciences” This study suggests that prenatal exposure to THC may negatively impact ovarian health in rats by altering miRNA expression, potentially leading to reproductive issues such as subfertility or premature reproductive senescence.
7 citations
,
June 2020 in “npj regenerative medicine” This study found that GDNF promotes hair formation and skin wound repair by enhancing the self-renewal and differentiation of bulge stem cells in mice.
6 citations
,
April 2024 in “Journal of Investigative Dermatology” This review highlights recent advances in CRISPR-based lineage tracing methods that can improve our understanding of skin stem cell behavior, regeneration, and disease, with potential applications in organoids and model organisms.
6 citations
,
September 2021 in “Autophagy” In this study on mouse preputial glands, suppressing ATG7-dependent autophagy delayed age-related changes, affected lipid metabolism, and reduced pheromone production, highlighting autophagy's roles in glandular homeostasis and cell breakdown.
6 citations
,
January 2015 in “Journal of regenerative medicine & tissue engineering” This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.
6 citations
,
June 2012 in “PloS one” This study identified a novel SCF mRNA splice variant in white merino sheep skin, which may play a role in hair follicle melanogenesis.
5 citations
,
December 2024 in “Pharmaceutics” This review discusses the potential of using nanomaterial-based drug delivery systems to improve the treatment of polycystic ovary syndrome but reports no new clinical results, highlighting future research directions.
5 citations
,
October 2022 in “Frontiers in Genetics” This study presents the first documented case of a woman with Alström syndrome successfully conceiving and giving birth, highlighting the importance of managing systemic comorbidities during pregnancy.
5 citations
,
October 2022 in “Heliyon” This review discusses infertility in polycystic ovary syndrome and therapeutic options, without reporting new results; it underscores the importance of personalized treatment plans based on patient needs and disease characteristics.
5 citations
,
May 2021 in “EMBO journal” This review discusses the role of polarity signaling in coordinating tissue mechanics, micro-environmental functions, and cell fate decisions, but it reports no new results, highlighting the need for further study in mammalian models.
4 citations
,
January 2025 in “The Journal of Cell Biology” This study found that deleting ceramide synthase 4 in skin epidermis stem cells disrupts hair follicle and skin barrier function, leading to immune responses similar to atopic dermatitis, due to imbalances in lipid composition affecting differentiation.
3 citations
,
August 2025 in “International Journal of Molecular Sciences” This review discusses various types of stem cells used in regenerative medicine, including adult stem cells and induced pluripotent stem cells (iPSCs), and evaluates them based on their embryonic tissue origins to explore new therapeutic approaches.