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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

PSA levels could help detect illegal steroid use in female athletes but face challenges like cost and PCOS prevalence.

Estrogen deficiency can reduce the enzyme activity needed to activate vitamin D.

People who carry the 21-Hydroxylase Deficiency gene are not more likely to have excessive male hormone levels.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Lichen Planopilaris and Frontal Fibrosing Alopecia may help us understand hair follicle stem cell disorders and suggest new treatments.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

Women generally handle heart enlargement better than men, but it's riskier for them if it occurs; hormones like estrogen offer some protection.

Birth control pills help treat skin and hair growth problems linked to high male hormone levels.

Hair growth is influenced by factors like genetics and nutrition, and more research is needed to understand hair loss and growth mechanisms.

Some supplements and hormones can increase hair loss by raising DHT levels.

The document concludes that alopecia has significant social and psychological effects, leading to a market for hair loss treatments.

AKR1D1 controls glucocorticoid levels and receptor activity in liver cells.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

More research is needed to understand how testosterone is maintained in adult males.

Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

Understanding genes and hormones is crucial for managing male puberty and sex development disorders.

A new mutation linked to partial Androgen Insensitivity Syndrome and prostate cancer was found in a patient unhappy with their female gender assignment.

Hormones affect skin aging and fat distribution, and treatments can help, but only minoxidil is proven for female hair loss.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

Early onset hair loss linked to genetics and androgen levels.

The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.

The conclusion suggests that PCOS may persist due to genetic traits that, while harmful for female fertility, could have provided survival and reproductive benefits to males.

Eyelash alopecia areata often goes undiagnosed and can lead to complete eyelash regrowth, especially in younger patients.

The document concludes that patient outcomes for Congenital Adrenal Hyperplasia are often not ideal because of poor management and a need for better diagnosis and treatment methods.

Estrogen and its receptors play a key role in hair growth, with differences between males and females.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

DHEA affects multiple receptors and may help with metabolic issues, but its safety and effectiveness in humans are unclear.