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Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Insulin resistance and high male hormone levels are major causes of Polycystic Ovary Syndrome.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

The document concludes that future heart disease research should account for sex-specific differences to improve diagnosis, treatment, and outcomes.

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Finasteride may cause lasting sexual, mental, and physical symptoms; use with caution.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

The document concludes that effectively managing PCOS requires a multifaceted approach.

5 alpha-reductase inhibitors can slightly improve symptoms of enlarged prostate but have a high risk of sexual side effects.

Allopregnanolone can reduce gut inflammation and normalize neurotransmitter levels after finasteride withdrawal.

Poor maternal nutrition can lead to fewer wool follicles in Chinese Merino sheep.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.

Common acne treatments can cause various side effects, like skin irritation and more serious issues, but combination therapies are often more effective and better tolerated.

Men are more likely to have severe respiratory viral infections like COVID-19 due to hormonal and genetic differences, while women generally have stronger immune responses.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

The document concludes that sexual and psychiatric side effects from 5-alpha-reductase inhibitors are reported, but more high-quality research is needed to understand how often they occur.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.

Dorper sheep's wool shedding is linked to specific genes and pathways, which may help understand human hair growth.

5-alpha reductase inhibitors slightly increase the risk of sexual and mood side effects, and breast growth in men.

Treat pattern hair loss with finasteride and topical minoxidil.

Women with acromegaly often have irregular periods due to hormone imbalances and growth hormone effects.

Finasteride might affect memory by impacting cholinergic system.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

PCOS causes infertility mainly due to hormonal imbalances, insulin resistance, and chronic inflammation.

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

The method accurately measures hormones and endocannabinoids in mice, showing gut microbiota diversity affects these levels and may influence stress and reproductive systems.