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This systematic review of five studies found that intradermal and intramuscular botulinum toxin injections showed promising hair growth outcomes for men with androgenic alopecia, but emphasizes caution due to a lack of control groups and small sample sizes.

In this study, researchers found that among 7,761 patients with androgenetic alopecia, behaviors such as insufficient sleep, poor dietary habits, alcohol consumption, heavy physical labor, and specific hairstyling choices were associated with increased severity of hair loss.

In this study, injecting foreskin-derived mesenchymal stromal cell exosomes into the scalps of men with androgenetic alopecia significantly increased hair density and patient satisfaction without side effects over a 12-week period.

This review addresses the causes, mechanisms, and treatment options for the most common non-scarring alopecias in females, including telogen effluvium, alopecia areata, and female pattern hair loss.

This study evaluated hormonal differences in males with early androgenetic alopecia, finding increased serum testosterone, prolactin, LH, LH/FSH, and FAI levels, with decreased FSH and SHBG levels, compared to controls without hair loss.

This review concluded that the efficacy of cosmeceutical hair serums for addressing hair loss lies in their use of bioactive peptides and plant compounds, like flavonoids and sterols, that target eight key contributing factors identified in hair loss conditions.

This review article reports recent advancements in understanding, diagnosing, and treating various hair loss conditions, like androgenetic alopecia and alopecia areata, including their genetic factors and new therapeutic options, while also examining the impact of COVID-19 on hair loss.

This article discusses various aspects of hair and scalp health, ancient philosophical perspectives on hair, and causes of hair disorders in children, without reporting new clinical results.

This study identified CXXC5 as a key mediator of hair loss induced by PGD2 and DHT via suppression of the Wnt/β-catenin pathway, with implications for potential therapeutic targets.

This study observed that individuals with androgenetic alopecia had abnormal correlations in hematologic parameters, suggesting a chronic, slowly progressing immune-related disorder tied to pubertal androgen secretion.

This review summarizes the clinical features and molecular causes of Primary Generalized Glucocorticoid Resistance, highlighting new findings from the characterization of mutations in the NR3C1 gene, but reports no new experimental results.

IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.

This study observed a high prevalence of androgenetic alopecia in patients hospitalized with severe COVID-19, with 79% of men and 42% of women affected, suggesting a potential link between androgen sensitivity and COVID-19 severity.

This study suggests that stress-induced premature senescence of dermal papilla cells may contribute to hair follicle aging by impairing critical epithelial-mesenchymal interactions and promoting inflammatory cytokine production.

This review discusses the dual role of testosterone in COVID-19 progression and suggests its importance in understanding the disease's mechanisms, highlighting the need for further targeted research.

This review outlines the evolution of hair follicle engineering and its foundational discoveries, but reports no new experimental results.

This review discusses the role of anti-Müllerian hormone in polycystic ovary syndrome and its male equivalent, but reports no new clinical findings; it suggests further investigation is needed into male relatives' reproductive function.

In this study, minoxidil significantly downregulated interleukin-1 alpha expression in human keratinocyte cells, suggesting an anti-inflammatory effect that may be a mechanism of action in treating alopecia.

This review discusses the pharmacology, toxicology, and clinical efficacy of flavonoids and saponins, highlighting the need for more data on their pharmacokinetics, interactions, and toxicities as most research is still in vitro.

This review discusses the roles of steroid hormone receptors in lung function related to COVID-19 and outlines ongoing clinical trials of steroid receptor ligands, but reports no new results.

This review discusses the off-label uses of retinoids in dermatology, focusing on oral isotretinoin and acitretin, and reports no new clinical results.

This review discusses the complex interplay of factors controlling hair regeneration and highlights the potential for targeted clinical applications in various hair disorders, while reporting no new clinical results.

In this study, 5-aminolevulinic acid photodynamic therapy did not improve hair growth in patients with androgenetic alopecia but was safe and slightly reduced scalp sebum secretion.

This case report details a postmenopausal woman with increased libido, hirsutism, and spontaneous orgasms, noting elevated testosterone levels and enlarged ovaries.

This article highlights that hormonal changes during menopause can significantly affect hair health, leading to decreased hair density, altered texture, and increased hair disorders, which may subsequently impact emotional well-being in women.

This study found that while clinical evidence is limited, early preclinical results suggest exosome treatment may enhance hair growth and warrant further research for therapeutic use in alopecia.

This study found that women diagnosed with PCOS who had hyperandrogenic symptoms at diagnosis were more likely to experience persistent androgenic symptoms and impaired quality of life in midlife.

This abstract outlines a guide reviewing both FDA-approved and off-label therapies for androgenetic alopecia and proposes treatment algorithms based on scientific research, highlighting a gap in common treatments for this prevalent condition.

This article reviews regenerative therapy for treating various types of hair loss and does not present new clinical findings.

This study found that knocking down SFRP2 in an AGA model improved hair regeneration and reduced cellular dysfunction, suggesting that targeting the SFRP2-FSTL1 axis could be a promising therapeutic strategy for androgenetic alopecia.