This review categorizes contractile hydrogels by their contraction mechanisms and explores their role in advanced wound management, emphasizing mechanical and biochemical signaling in healing, but also notes challenges like force transmission and clinical applicability.
April 2026 in “Clinical Cosmetic and Investigational Dermatology” This review highlights the varied therapeutic applications of punch-based techniques in dermatologic surgery, noting consistent evidence for follicular unit extraction in androgenetic alopecia, but more mixed results for scar treatment, vitiligo, and chronic wounds, warranting further standardized research.
In this study, the researchers developed a biomimetic multilayer composite scaffold combining a decellularized amniotic membrane, fibroblast-laden collagen gel, and epidermal stem cells, which healed full-thickness skin wounds more quickly and effectively by regenerating hair follicles without scarring compared to Moropicin ointment.
This review discusses the potential of using Arabidopsis thaliana to express fusion protein TDP1-KGF-2, aiming to enhance the transdermal delivery of KGF-2 for hair growth applications, despite current challenges with production costs and efficacy.
August 2024 in “Indian Journal of Skin Allergy” This review outlines the current state of stem cell therapy in dermatology, highlighting its potential for treating a variety of skin disorders and conditions, while emphasizing the need for further controlled studies to standardize treatment and fully understand its efficacy and limitations.
Scalp micropigmentation usually needs two to three sessions, but factors like genetics, coverage area, and health conditions can require more.
13 citations
,
February 2017 in “Science” Turning scar-forming cells into fat cells can reduce scarring.
1 citations
,
December 2023 in “Life” This article discusses the potential role of telocytes in skin regeneration and the need to understand their interaction with platelet-rich plasma, reporting no new experimental results.
June 1997 in “The American Journal of Cosmetic Surgery” This article discusses two donor site reharvesting methods that may allow further hair restoration sessions and improve donor scar aesthetics but reports no new clinical results.
April 2018 in “Journal of Investigative Dermatology” In this animal study, the researchers found that DPP4 plays a crucial role in scar formation and wound-induced hair follicle neogenesis in mice, impacting regenerative repair.
4 citations
,
August 2018 in “Journal of Cosmetic Dermatology” In this study, wound closure tension following strip surgery for hair restoration varied by strip width, highlighting the importance of minimizing tension to achieve better scarring outcomes.
10 citations
,
July 2011 in “Springer eBooks” This review describes the use of carbon dioxide for aesthetic treatments like skin rejuvenation and scar reduction but does not present new clinical findings.
December 2023 in “Ophtha Therapy” In this study, the aim was to define the indications, diagnostics, and surgical techniques for eyebrow lift procedures, noting that the primary complication is a visible scar, especially concerning for individuals with a tendency for keloid formation.
49 citations
,
August 2016 in “Aesthetic Surgery Journal” This study found that micro-needling with cosmeceuticals or platelet-rich plasma significantly improved wrinkles, skin laxity, scar softening, and hair growth over 12 months, with minimal side effects, and that the best results occur with pigment and platelet massaging between 5 to 30 minutes post-treatment.
24 citations
,
September 2018 in “Journal of Materials Science: Materials in Medicine” In this study using rabbits, HA2 hydrogels made from cross-linked hyaluronic acid and polysaccharide promoted wound healing better than other treatments, reducing inflammation and scar formation.
7 citations
,
June 1992 in “The Journal of Dermatologic Surgery and Oncology” This discussion reviews hair transplantation as a treatment for thinning, hairline restoration, or scar coverage in females, offering no new clinical findings.
3 citations
,
July 1987 in “Dermatologic Clinics” This article discusses scalp reductions for male-pattern baldness and reports potential challenges, such as stretch-back and scar-related styling issues, without providing new clinical results.
408 citations
,
January 2017 in “Science” This study found that hair follicles in mice and humans can convert wound-related myofibroblasts into adipocytes, suggesting a potential pathway to reduce scar formation by activating BMP signaling.
10 citations
,
April 2008 in “Journal of Pediatric Surgery” In this study, researchers found that the absence of P-selectin delays inflammatory cell recruitment and reepithelialization in fetal wounds, although scar formation still occurs in later gestation wounds.
December 2015 in “Dermatologic Surgery” Double trichophytic closure effectively repairs thin scalp scars, reducing financial burden.
2 citations
,
January 2023 in “Biomedicines” This study found that using a combination of ablative CO₂ fractional laser and fetal fibroblast transplantation significantly reduced scarring in mice, with long-term sphere-forming cultured fibroblasts producing scar appearances closest to normal skin.
36 citations
,
February 2016 in “British journal of pharmacology” This study found that SIRT1 negatively regulates fibroblast activation and excessive scar formation, suggesting it may be a promising drug target for treating hypertrophic scars.
November 2025 in “Journal of Clinical Medicine” This study found that platelet-rich plasma may improve patient-reported outcomes for scar symptoms like pain and itching at six months, although no significant changes in scar appearance were observed at three months.
10 citations
,
January 2007 in “Dermatologic Surgery” This study reported that a new surgical technique resulted in minimal scars visible to the naked eye in most cases, suggesting a significant improvement over conventional closure techniques.
8 citations
,
June 2022 in “International Journal of Molecular Sciences” This review discusses the potential of extracellular vesicles for facial aesthetic applications, including scar reduction and skin rejuvenation, but reports no new clinical results; further research into production and mechanisms is needed.
13 citations
,
November 2024 in “Anais Brasileiros de Dermatologia” This abstract highlights the potential applications of exosomes in dermatology, including scar treatment and hair regeneration, but notes that further clinical studies are needed to confirm their safety and efficacy and address regulatory challenges.
5 citations
,
November 2023 in “Journal of Investigative Dermatology” This study observed that cutaneous microwounds created by fractional photothermolysis heal differently from typical wounds, displaying rapid re-epithelialization and limited inflammation, which may help reduce scar formation by delaying collagen remodeling and minimizing myofibroblast activation.
1 citations
,
April 2018 in “Lasers in Surgery and Medicine” This review summarizes late-breaking abstracts from the American Society for Laser Medicine and Surgery, 2018, and reports no new clinical findings.
1 citations
,
January 2014 in “Archives of Aesthetic Plastic Surgery” This study found that follicular unit extraction for Asian female hairline surgery produced satisfactory aesthetic results without leaving a linear scar, contrary to some surgeons' beliefs about its limitations.
November 2020 in “Journal of Cosmetic Dermatology” This study conducted in a hair restoration clinic found that using the vertical scalp mobility method resulted in a significantly greater number of hairs available from the donor strip compared to the horizontal method, with an increase of approximately 970 hairs (P < .05).