Search
for

    Glossary ROCK inhibitor

    blocks enzymes involved in cell contraction and motility

    A ROCK inhibitor, also known as a Rho-associated kinase inhibitor, is a type of drug that blocks the activity of Rho-associated kinases (ROCKs). These enzymes play a crucial role in various cellular functions, including contraction, motility, proliferation, and apoptosis. By inhibiting ROCKs, these drugs can help treat conditions like hypertension, glaucoma, and even promote hair growth in cases of alopecia by improving blood flow and reducing inflammation.

    Related Terms

    Sort by

    Research 30 of 443

    1. ROCK inhibitor Y-27632 maintains the propagation and characteristics of hair follicle stem cells. PubMed · 2018 · 12 citations
    2. Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632 Frontiers in cell and developmental biology · 2021 · 16 citations
    3. 557 Short-term Rho-associated kinase inhibitor treatment accelerates primary keratinocyte growth without affecting the characteristics of the stem cell population Journal of Investigative Dermatology · 2022
    4. Efficient expansion of human keratinocyte stem/progenitor cells carrying a transgene with lentiviral vector Stem Cell Research & Therapy · 2013 · 18 citations
    5. Boosting and Rescuing Epidermal Superior Population from Fresh Keratinocyte Cultures Stem Cells and Development · 2013 · 15 citations
    6. Dysregulated behaviour of hair follicle stem cells triggers alopecia and provides potential therapeutic targets Experimental Dermatology · 2022 · 3 citations
    7. Efficient establishment of an optimized culture condition for cashmere goat primary hair follicle stem cells 2023
    8. Regulatory T cells modulate bone marrow stromal cell osteogenesis by activating ROCK-myosin axis and cell contractility 2026
    9. Differentiation of Human Pluripotent Stem Cells Into Definitive Endoderm Cells in Various Flexible Three-Dimensional Cell Culture Systems: Possibilities and Limitations Frontiers in Cell and Developmental Biology · 2021 · 13 citations
    10. Curcumin derivatives inhibit testicular 17β-hydroxysteroid dehydrogenase 3 Bioorganic & Medicinal Chemistry Letters · 2010 · 19 citations
    11. Deciphering principles of morphogenesis from temporal and spatial patterns on the integument Developmental Dynamics · 2015 · 19 citations
    12. Mycophenolate Antagonizes IFN-γ-Induced Catagen-Like Changes via β-Catenin Activation in Human Dermal Papilla Cells and Hair Follicles International Journal of Molecular Sciences · 2014 · 11 citations
    13. Identifying the Target Cells and Mechanisms of Merkel Cell Polyomavirus Infection Cell Host & Microbe · 2016 · 133 citations
    14. Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Chemistry & biology · 2012 · 474 citations
    15. Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930 Molecular cancer therapeutics · 2011 · 65 citations
    16. Psychocutaneous disease Journal of The American Academy of Dermatology · 2017 · 38 citations
    17. Hair growth promotion by Necrostatin-1s Scientific Reports · 2020 · 12 citations
    18. Type-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe? Frontiers in Immunology · 2024
    19. Formestane Preferred as Second-Line Therapy in Advanced Breast Cancer Drugs & Therapy Perspectives · 1993
    20. A Hot New Twist to Hair Biology ˜The œAmerican journal of pathology (Print) · 2005 · 174 citations
    21. Endocrine control of benign prostatic hyperplasia Andrology · 2016 · 97 citations
    22. Oncogenic senescence: a multi-functional perspective Oncotarget · 2017 · 32 citations
    23. Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway Frontiers in Bioengineering and Biotechnology · 2021 · 13 citations
    24. Androgen Deprivation Therapy in Prostate Cancer: Focusing on Sexual Side Effects The Journal of Sexual Medicine · 2012 · 35 citations
    25. Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche. Journal of Investigative Dermatology · 1998 · 10 citations
    26. Tyrosine Kinases in Autoimmune and Inflammatory Skin Diseases Frontiers in immunology · 2019 · 88 citations
    27. Bee pollen and honey for the alleviation of hot flushes and other menopausal symptoms in breast cancer patients Molecular and clinical oncology · 2015 · 24 citations
    28. Commonalities Between COVID-19 and Radiation Injury Radiation Research · 2020 · 18 citations
    29. Pimecrolimus interferes the therapeutic efficacy of human mesenchymal stem cells in atopic dermatitis by regulating NFAT-COX2 signaling Stem Cell Research & Therapy · 2021 · 11 citations
    30. Repigmentation Competence in Vitiligo: Integrating Immune, Regulatory, Regenerative, and Microenvironmental Axes Journal of Personalized Medicine · 2026