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    Glossary Retinoic Acid

    derivative of Vitamin A used in acne and wrinkle treatment

    Retinoic Acid, also known as Tretinoin or ATRA (All-trans Retinoic Acid), is a derivative of Vitamin A that plays a crucial role in cell growth and differentiation. It is commonly used in dermatology to treat acne and reduce wrinkles by promoting the turnover of skin cells and increasing collagen production.

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    1. Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse Mechanisms of development · 2002 · 232 citations
    2. Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla Journal of Investigative Dermatology · 2005 · 92 citations
    3. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    4. Self-assembled polymeric nanocarriers for the targeted delivery of retinoic acid to the hair follicle Nanoscale · 2015 · 59 citations
    5. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk Nature Communications · 2014 · 51 citations
    6. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle 2007 · 48 citations
    7. Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3 Nature Communications · 2019 · 47 citations
    8. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    9. Molecular cloning of two novel types of peptidylarginine deiminase cDNAs from retinoic acid‐treated culture of a newborn rat keratinocyte cell line FEBS Letters · 1998 · 39 citations
    10. Treatment of Psoriasis vulgaris with a New Retinoic Acid Derivative Ro 10-9359 Dermatology · 1977 · 39 citations
    11. Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1 Journal of cellular physiology · 1996 · 37 citations
    12. The Aldo-Keto Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid Pathway Dysregulation in the Pathogenesis of Keloid Disease Journal of Investigative Dermatology · 2016 · 31 citations
    13. Cutaneous Retinoic Acid Levels Determine Hair Follicle Development and Downgrowth 2012 · 31 citations
    14. Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation 2004 · 29 citations
    15. Retinoic acid in the treatment of eruptive vellus hair cysts Journal of the American Academy of Dermatology · 1981 · 28 citations
    16. Retinoic Acid and Mouse Skin Morphogenesis. I. Expression Pattern of Retinoic Acid Receptor Genes During Hair Vibrissa Follicle, Plantar, and Nasal Gland Development Journal of Investigative Dermatology · 1994 · 24 citations
    17. Cellular localization of retinoic acid receptor-gamma expression in normal and neoplastic skin. PubMed · 1992 · 23 citations
    18. DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo BioMed Research International · 2019 · 20 citations
    19. Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid Archives of Dermatological Research · 1993 · 18 citations
    20. Retinoic Acid and Mouse Skin Morphogenesis. II. Role of Epidermal Competence in Hair Glandular Metaplasia Developmental Biology · 1994 · 16 citations
    21. Tgm2/Gh, Gbx1 and TGF-beta are involved in retinoic acid-induced transdifferentiation from epidermis to mucosal epithelium The International Journal of Developmental Biology · 2011 · 14 citations
    22. All-trans-retinoic acid inhibits mink hair follicle growth via inhibiting proliferation and inducing apoptosis of dermal papilla cells through TGF-β2/Smad2/3 pathway Acta histochemica · 2020 · 10 citations
    23. Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis Journal of Investigative Dermatology · 2004 · 10 citations
    24. [Genetic dissection of retinoic acid function in epidermis physiology]. PubMed · 2002 · 9 citations
    25. Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration Drug Delivery · 2010 · 7 citations
    26. Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function 2021 · 5 citations
    27. Hypothesis: Wound‐induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration Experimental dermatology · 2019 · 5 citations
    28. Collodion baby case series: the success of oral retinoic acid Türk pediatri arşivi : İstanbul çocuk kliniği dergisi · 2018 · 4 citations
    29. Highly Efficient Neural Differentiation of CD34-Positive Hair-Follicle-Associated Pluripotent Stem Cells Induced by Retinoic Acid and Serum-Free Medium Methods in molecular biology · 2016 · 4 citations
    30. Effects of <i>in utero</i> retinoic acid exposure on mouse pelage hair follicle development Veterinary Dermatology · 2002 · 4 citations