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    Glossary Retinoic Acid Signaling

    regulates gene expression through vitamin A derivatives

    Retinoic Acid Signaling, also known as RA signaling, is a biological pathway where retinoic acid, a derivative of vitamin A, binds to specific receptors in cells to regulate gene expression. This pathway is crucial for various physiological processes, including cell growth, differentiation, and embryonic development. In the context of hair biology, RA signaling can influence hair follicle development and cycling, potentially impacting conditions like alopecia.

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    1. Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    2. Immunolocalization of proteins related to retinoic acid synthesis and signaling during hair cycle 2009
    3. Spontaneous tumour regression in keratoacanthomas is driven by Wnt/retinoic acid signalling cross-talk Nature Communications · 2014 · 51 citations
    4. Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling Developmental biology · 2008 · 84 citations
    5. Correction to ‘Retinoic acid drives hair follicle stem cell activation via Wnt/β‐catenin signalling in androgenetic alopecia’ Journal of the European Academy of Dermatology and Venereology · 2025
    6. 944 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration Journal of Investigative Dermatology · 2019
    7. 1410 Non-coding double stranded RNA induces retinoic acid synthesis and retinoid signaling to control regeneration 2018
    8. Effects of Retinoic Acid on Wingless (WNT) Signaling in the Hair Follicles of Mice The Knowledge Bank (The Ohio State University) · 2010
    9. Retinoic acid drives hair follicle stem cell activation via Wnt/β‐catenin signalling in androgenetic alopecia 2024
    10. Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle 2007 · 48 citations
    11. Hypothesis: Wound‐induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration Experimental dermatology · 2019 · 5 citations
    12. Hair Vibrissa Follicle Morphogenesis is Linked to the Expression of Retinoic Acid Receptors α and γ Genes Biology of the Cell · 1992
    13. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    14. Krt6a-Cre Transgenic Mice Direct LoxP-Mediated Recombination to the Companion Cell Layer of the Hair Follicle and Following Induction by Retinoic Acid to the Interfollicular Epidermis Journal of Investigative Dermatology · 2004 · 10 citations
    15. Aberrant Wnt signalling induces comedo-like changes in the upper hair follicle Research Square (Research Square) · 2020 · 1 citations
    16. Dietary vitamin A regulates wingless-related MMTV integration site signaling to alter the hair cycle Experimental Biology and Medicine · 2014 · 18 citations
    17. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle 2021 · 4 citations
    18. All-trans retinoic acid modulates proliferation and apoptosis of secondary hair follicle–dermal papilla cells in cashmere goats via the TGF-β2/Smad2/3 pathway Frontiers in Veterinary Science · 2026
    19. Hair Cycle-Specific Immunolocalization of Retinoic Acid Synthesizing Enzymes Aldh1a2 and Aldh1a3 Indicate Complex Regulation 2004 · 29 citations
    20. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing Cell stem cell · 2020 · 128 citations
    21. Alopecia Associated with Indinavir Therapy 1999 · 38 citations
    22. Through the lens of hair follicle neogenesis, a new focus on mechanisms of skin regeneration after wounding Seminars in Cell & Developmental Biology · 2019 · 28 citations
    23. Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands 2019 · 16 citations
    24. Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development bioRxiv (Cold Spring Harbor Laboratory) · 2020
    25. Retinoids in scarless skin regeneration: from molecular mechanisms to therapeutic strategies Frontiers in Cell and Developmental Biology · 2025
    26. Controlled microtrauma opens a regenerative window for appendage-bearing skin repair bioRxiv (Cold Spring Harbor Laboratory) · 2026
    27. Dermal EZH2 orchestrates dermal differentiation and epidermal proliferation during murine skin development Developmental biology · 2021 · 6 citations
    28. CD201+ fascia progenitors choreograph injury repair Research Square (Research Square) · 2022 · 5 citations
    29. UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia Proceedings of the National Academy of Sciences · 2025
    30. INVESTIGATIONS INTO THE ROLE OF THE X-LINKED EPIGENETIC REGULATOR UTX (KDM6A) IN SELF-RENEWING STRATIFYING EPITHELIA Scholarly Commons (University of Pennsylvania) · 2025