21 citations
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January 2019 in “Experimental dermatology” This review explores how low-energy He-Ne laser therapy may stimulate repigmentation in vitiligo by affecting mitochondrial pathways and melanocyte function, but does not report new clinical results.
December 2025 in “Clinical Case Reports” This study found that exosome injections from human umbilical cord, with or without polydeoxyribonucleotide, promoted regrowth and repigmentation of white beard hairs and improved scarring in a 35-year-old man with refractory alopecia areata, suggesting potential as a minimally invasive regenerative treatment.
November 2025 in “Journal of Cosmetic Dermatology” This study found that exosome-based therapy using rose stem cell-derived exosomes may safely induce hair repigmentation in individuals with gray hair, particularly for those with shorter durations of graying and androgenetic alopecia.
August 2025 in “Annals of Medicine” This study found that mycophenolate mofetil can enhance skin pigmentation in vitiligo models by activating the WNT signaling pathway and increasing melanin-related gene expression.
17 citations
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January 2015 in “Dermatology online journal” This report describes a patient experiencing hair repigmentation linked to adalimumab therapy, a TNF inhibitor, a phenomenon not previously associated with this class of drugs.
9 citations
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December 2010 in “Journal of The European Academy of Dermatology and Venereology” This letter reports repigmentation of hair in patients receiving latanoprost therapy.
12 citations
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May 2018 in “JAAD Case Reports” This case report describes a patient with psoriasis who experienced scalp hair darkening and increased growth during anti–IL-17 therapy.
January 2024 in “Dermatologic therapy” This study reported that fire needle therapy improved skin lesions, increased melanocyte numbers, and boosted melanin levels in a vitiligo mouse model by upregulating the Wnt/β-catenin signalling pathway, suggesting its potential role in treating vitiligo through promoting pigmentation.
9 citations
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July 2016 in “The Journal of Dermatology” This letter to the editor discusses an observed case of hair repigmentation linked with etretinate therapy but reports no new research findings.
17 citations
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November 2013 in “Clinical and experimental dermatology” This case report describes repigmentation and curling of hair in a patient undergoing acitretin therapy.
November 2025 in “Journal of Investigative Dermatology” Combining MMP-9 and JAK inhibitors can effectively prevent skin depigmentation in vitiligo.
December 2025 in “Clinical Case Reports” The exosome injections were from stem cells and plants, not umbilical cords.
6 citations
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January 2018 in “International Journal of Dermatology” This study observed that different vitiligo lesions display varying repigmentation patterns, which are associated with the extent of depigmentation, sun exposure, lesion stage, and type of therapy used.
84 citations
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January 1990 in “Journal of The American Academy of Dermatology” This study reported successful repigmentation without scarring in patients with localized and segmental vitiligo after epidermal grafting, but the Koebner phenomenon hindered similar results in some with generalized vitiligo.
52 citations
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January 2016 in “Brazilian Journal of Medical and Biological Research” In this study, patients with generalized vitiligo treated with a combination of oral compound glycyrrhizin and UVB light showed the most effective repigmentation and disease stabilization compared to other treatment groups.
31 citations
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April 2019 in “Cell reports” This study found that human iPSC-derived melanocytes from vitiligo patients successfully integrated into mouse hair follicles and epidermis, demonstrating potential for personalized therapy for depigmentation.
24 citations
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September 2008 in “Clinical and experimental dermatology” Repigmentation in vitiligo may come from melanocyte stem cells in the skin.
10 citations
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January 2010 in “Acta dermato-venereologica” Light therapy can effectively treat vitiligo and hair loss caused by a specific medication.
6 citations
,
October 2006 Understanding repigmentation mechanisms in vitiligo can improve treatments and patient outcomes.
March 2026 in “Clinical Cosmetic and Investigational Dermatology” This research found that combining a 308-nm excimer laser with oral compound glycyrrhizin and topical 0.03% tacrolimus was more effective for treating pediatric facial and cervical vitiligo, resulting in faster and higher rates of repigmentation with minimal adverse effects compared to glycyrrhizin and tacrolimus alone.
This review discusses various techniques for depigmentation in vitiligo patients and suggests that cryotherapy, performed by an experienced professional, may be the most cost-effective and accessible method.
April 2019 in “Institutional Repositories DataBase (IRDB)” This study demonstrated that human iPSC-derived melanocytes, when transplanted into mice, can reconstitute pigmented hair follicles and integrate into normal tissue, suggesting their potential as a cellular therapy for depigmentation.
9 citations
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November 2015 in “JAMA dermatology” This case study describes an elderly woman with distinctive black hair patches and scalp pigmentation, but it does not provide a diagnosis or new findings.
4 citations
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November 2021 in “Molecular Medicine Reports” In this study on a mouse model of vitiligo, NB-UVB/ADSC combination therapy improved oxidative stress and calcium homeostasis, but the protective effect was reversed by inhibiting Nr2 signaling.
2 citations
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September 2020 in “International journal of radiology & radiation therapy” This study describes changes in scalp hair color, including rare instances of repigmentation, following volumetric modulated arc therapy for skin cancer; this potential side effect may warrant discussion during informed consent.
June 2022 in “World Journal Of Advanced Research and Reviews” This case report describes successful hair regrowth and repigmentation in a patient with scalp-localized alopecia areata following treatment with Sunetics Laser therapy.
February 2025 in “Dermatologic Surgery” This review highlights the expanding medical applications of follicular unit excision, suggesting it might be effective for conditions like chronic ulcers, axillary hyperhidrosis, bromhidrosis, vitiligo, and scar remodeling, although further research is needed.
1 citations
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April 2025 in “Pigment Cell & Melanoma Research” This article reviews the underlying mechanisms of segmental vitiligo with white hair, focusing on skin and hair follicle melanocytes, and proposes potential targets for treatment, highlighting neuroendocrine factors as possible contributors to the condition.
1 citations
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June 2022 in “Zenodo (CERN European Organization for Nuclear Research)” This study reports a rare case of alopecia areata on the scalp that was successfully treated with Sunetics Laser therapy, resulting in hair regrowth and repigmentation in areas of previous hair loss.
October 2010 in “eCommons (Cornell University)” This case report highlights that cutaneous epitheliotropic lymphoma in dogs can present with various skin lesions, such as depigmentation, making diagnosis challenging for veterinarians.