research Carica Papaya Flower Extracts Possess Antioxidant and 5α-Reductase Inhibitory Activities
Papaya flower extract may help with hair growth by blocking a hair loss enzyme and acting as an antioxidant.
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research Targeting JAK/STAT and Wnt/Beta-Catenin Pathways and 5-Alpha-Reductase Activity to Develop an Effective Anti-Hair Loss Product
The lotion with specific plant extracts effectively increased hair growth and improved hair cycle in subjects after 3 months.
research Longitudinal Clinical Course in Patients With 5α-Reductase Type 2 Deficiency Treated With Testosterone and Dihydrotestosterone During Infancy and Puberty
Testosterone and dihydrotestosterone treatments can help with penile growth in males with 5α-reductase type 2 deficiency, with dihydrotestosterone being more effective in infancy.
research A Role for Steroid 5 Alpha-Reductase 1 in Vascular Remodeling During Endometrial Decidualization
The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.
research Isolation and HPLC Quantitative Determination of 5α-Reductase Inhibitors from Tectona Grandis Leaf Extract
Teak leaf extract contains compounds that could help treat hair loss.
research Synthesis of Novel Androstane-N-Cyclohexyl-17-Carboxamides and Their Effect on 5α-Reductase Isoform 2, Androgen Receptor, and Androgen-Dependent Glands
New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.
research Standardization of Amarantha Hair Oil with Special Reference to Identification of β-Sitosterol as Major Component Having 5α-Reductase Inhibitory Activity/Hair Growth Promoting Activity
Amarantha hair oil contains β-sitosterol, which helps promote hair growth.
research Structural Basis for the Catalysis and Inhibition of Human Steroid 5α-Reductase 2
The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.
research Vibrational Spectroscopic Investigation and Molecular Structure of a 5α-Reductase Inhibitor: Finasteride
Finasteride's molecular properties and active sites were identified using computational methods.
research Ageratum Conyzoides L. Extract Inhibits 5α-Reductase Gene Expression and Prostaglandin D2 Release in Human Hair Dermal Papilla Cells and Improves Symptoms of Hair Loss in Healthy Males and Females in an Open Label Pilot Study
Ageratum conyzoides L. extract may effectively and safely treat hair loss.
research In Vitro and In Vivo Effects of 17β-N-(4-Phenylcarbamoyl) Androst-4-en-3-one Derivatives as 5α-Reductase Inhibitors on Androgen-Dependent Glands
Three compounds were found to inhibit a prostate disease-related enzyme and reduce prostate size more effectively than the current treatment, suggesting they could be used for treating benign prostatic hyperplasia.
research Attenuation of 5α-Reductase-Mediated Progesterone Metabolism Promotes Differentiation of Human Endometrial Stromal Cells for the Establishment of Pregnancy
Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.
research Development of Microemulsions Containing Carthamus Tinctorius Extract for 5α-Reductase Inhibition
A microemulsion with Carthamus tinctorius extract effectively inhibits 5α-reductase and improves skin and hair follicle delivery.
research Enzyme Inhibitory Activities of Marine Sponges Against Cholinesterase and 5α-Reductase
Marine sponges from Tabuhan Island can inhibit enzymes linked to Alzheimer's and hair loss.
research The Efficacy of Ostrich Antibodies to Dihydrotestosterone and 5α-Reductase in the Restoration of Hair Growth
Ostrich antibodies can help restore hair growth in people with a specific type of hair loss, increasing hair count by 71% on average.
research Inhibition of 5α-Reductase of De Novo Generation of Short Antioxidant Peptides
DK peptides can reduce hair loss by inhibiting the 5α-reductase enzyme and have antioxidant effects.
research Disorders in Male Sexual Differentiation Due to 5α-Reductase-2 Deficiency
5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.
research Investigation of Antioxidant Activity of Cynanchi Wilfordii Radix and Inhibitory Effect of 5α-Reductase mRNA in Human Dermal Papilla Cells
Cynanchi Wilfordii Radix has strong antioxidant effects and may help treat male hair loss.
research Symptoms of Hypogonadism Caused by 5α-Reductase Inhibitors
A man's low testosterone and related symptoms improved after he stopped taking hair loss drugs.
research Women Also Use 5α-Reductase Inhibitors
Women also use 5α-reductase inhibitors for hair loss and hirsutism.
research Women Also Use 5α-Reductase Inhibitors—Reply
Women also use 5α-reductase inhibitors, and their effects differ from men.
research Effect of 5α-Reductase Inhibitors on Sexual Function: A Meta-Analysis and Systematic Review of Randomized Controlled Trials
5α-Reductase inhibitors can negatively impact sexual function.
research 5α-Reductases in Human Physiology: An Unfolding Story
Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial
Testosterone increases muscle mass regardless of DHT conversion blocking.
research Screening of Steroid 5-Reductase Inhibitory Activity and Total Phenolic Content of Thai Plants
Ocimum basilicum L. and red Oryza sativa L. may help with hair loss and prostate issues.
research 5α-Reductase Inhibitor Therapy: Should Physicians Be Concerned With Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients?
Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.
research Screening 5α-Reductase Inhibitors from Plant Extraction for Treatment of Androgenic Alopecia In Vitro
Coffee extract and caffeotannic acid can help treat hair loss.
research A New Look at the 5α-Reductase Inhibitor Finasteride
Finasteride, a medication, is being re-evaluated for its effects and uses.
research Effect of the Dual 5α-Reductase Inhibitor Dutasteride on Markers of Tumor Regression in Prostate Cancer
Dutasteride may help treat prostate cancer by causing cancer cells to shrink and die.
research Dihydrotestosterone and 5α-Reductase: Role in Hair Loss and Prostate Health
Dihydrotestosterone and 5α-Reductase play a role in hair loss and prostate health, and finasteride can increase hair growth in men without affecting sperm production, but it doesn't work for postmenopausal women with hair loss.