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    Glossary Reconstructed Human Epidermis

    laboratory-grown model of human skin for research and testing

    Reconstructed Human Epidermis (RHE) is a laboratory-grown model of human skin created from cultured human skin cells. It mimics the structure and function of the outermost layer of the skin, making it a valuable tool for testing cosmetics, pharmaceuticals, and studying skin biology without the need for animal testing.

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    1. Expression of type 1 5α-reductase and metabolism of testosterone in reconstructed human epidermis (SkinEthic®): a new model for screening skin-targeted androgen modulators International Journal of Cosmetic Science · 2000 · 3 citations
    2. Nanostructured lipid carriers loaded with an association of minoxidil and latanoprost for targeted topical therapy of alopecia European Journal of Pharmaceutics and Biopharmaceutics · 2022 · 9 citations
    3. Folate bioavailability in reconstructed skin models and effects of folate in a monolayer wound healing assay. Approaches on topic application bioRxiv (Cold Spring Harbor Laboratory) · 2021
    4. Nanostructured Lipid Carriers Loaded with an Association of Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia Social Science Research Network · 2021
    5. Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro Journal of Tissue Engineering and Regenerative Medicine · 2020 · 29 citations
    6. Establishment of a new three‐dimensional human epidermal model reconstructed from plucked hair follicle‐derived keratinocytes Experimental Dermatology · 2016 · 12 citations
    7. The patch assay reconstitutes mature hair follicles by culture-expanded human cells Regenerative Medicine · 2017 · 11 citations
    8. The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions International Journal of Molecular Sciences · 2022 · 11 citations
    9. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin Genetics in medicine · 2018 · 10 citations
    10. A Fibrous Hybrid Patch Couples Cell-Derived Matrix and Poly(l-lactide-<i>co</i>-caprolactone) for Endothelial Cells Delivery and Skin Wound Repair ACS Biomaterials Science & Engineering · 2018 · 16 citations
    11. Skin equivalent assay: An optimized method for testing for hair growth reconstitution capacity of epidermal and dermal cells Experimental Dermatology · 2019 · 8 citations
    12. Cystine-thiamin-containing hair-growth formulation modulates the response to UV radiation in an in vitro model for growth-limiting conditions of human keratinocytes Journal of Photochemistry and Photobiology B-biology · 2018 · 9 citations
    13. Chemically induced transformation of human dermal fibroblasts to hair‐inducing dermal papilla‐like cells Cell Proliferation · 2019 · 8 citations
    14. Use of extracellular matrix hydrogel from human placenta to restore hair-inductive potential of dermal papilla cells Regenerative Medicine · 2019 · 31 citations
    15. Dissociated skin cells regenerate hair follicles in a microwound, “The Punch Assay” Experimental Dermatology · 2018 · 5 citations
    16. Generation of human-induced pluripotent stem cell-derived adherent 3-dimensional skin hair-follicle organoids Organoid · 2022 · 2 citations
    17. 1328 HIF1A stabilisation in the human hair follicle promotes glycolysis Journal of Investigative Dermatology · 2018
    18. Influence of donor sources and culture media on the histo-morphological quality of human artificial skin models Online Publication Service of Würzburg University (Würzburg University) · 2018
    19. Skin penetration of active folate salts and their effects on wound healing in vitro: new approaches for dermal folate application 2023 · 1 citations
    20. Protective Effect of Iris germanica L. Rhizome-Derived Exosome against Oxidative-Stress-Induced Cellular Senescence in Human Epidermal Keratinocytes Applied sciences · 2023
    21. N,N-Dimethylglycine Sodium Salt Exerts Marked Anti-Inflammatory Effects in Various Dermatitis Models and Activates Human Epidermal Keratinocytes by Increasing Proliferation, Migration, and Growth Factor Release International Journal of Molecular Sciences · 2023
    22. Planar Proton Minibeam Irradiation Elicits Spatially Confined DNA Damage in a Human Epidermis Model Cancers · 2022 · 8 citations
    23. Beyond the Epidermal-Melanin-Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity International Journal of Molecular Sciences · 2023
    24. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    25. From basic biology to engineered therapies: the keratinocyte stem cell playbook Frontiers in Medical Technology · 2026
    26. Human dermal stem cells differentiate into functional epidermal melanocytes Journal of Cell Science · 2010 · 164 citations
    27. Stratum-Specific Expression of Human Transferrin Receptor Increases Iron in Mouse Epidermis Journal of Investigative Dermatology · 2006 · 14 citations
    28. Pre-aggregation of scalp progenitor dermal and epidermal stem cells activates the WNT pathway and promotes hair follicle formation in in vitro and in vivo systems Stem Cell Research & Therapy · 2019 · 17 citations
    29. Sensory Reinnervation of Human Skin by Human Neural Stem Cell‒Derived Peripheral Neurons Ex Vivo 2021 · 7 citations
    30. Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment Stem cell research & therapy · 2021 · 14 citations