618 citations
,
January 2018 in “Cochrane Database of Systematic Reviews” This study reported that selenium supplements do not reduce cancer risk and may increase the risk of type 2 diabetes and high-grade prostate cancer, while observational studies suggest mixed associations between selenium exposure and cancer incidence.
26 citations
,
February 2002 in “Urologic clinics of North America” This review examines the placebo response in conditions such as allergies and weight loss, highlighting its significance in both conventional and alternative medicine randomized trials, without reporting any new results.
2 citations
,
July 2020 in “Journal of Applied Pharmaceutical Science” This study examined the preservative and antimicrobial susceptibility of non-fermenting bacilli collected from beauty salon waste in Brazil.
November 2023 in “British journal of nutrition” This study found that curcumin supplementation in adults significantly increased serum adiponectin levels and decreased leptin levels, based on a meta-analysis of 13 randomized controlled trials.
150 citations
,
February 2008 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study suggests that antiandrogens may slightly reduce hirsutism severity compared to placebo, but evidence is weak and their relative efficacy remains uncertain.
95 citations
,
April 2013 in “PLOS ONE” This review reports that while ginseng's safety profile seems favorable, the evidence for its clinical efficacy remains limited due to generally poor study quality in the included Korean randomized trials.
39 citations
,
January 2015 in “Cochrane library” This systematic review found no clear evidence of a difference in survival outcomes between treatment regimens with or without chemotherapy for children with medulloblastoma, and further high-quality research is needed.
September 2023 in “Medical & Clinical Case Reports Journal” This review found that while platelet-rich plasma treatment significantly increased hair density compared to baseline in people with androgenetic alopecia, its effectiveness was not significant compared to placebo in most studies.
This review found inconsistent evidence on the effectiveness of oral finasteride for hair loss reversal in men with androgenetic alopecia, with one study showing significant results and others not.
93 citations
,
March 2014 in “Cochrane Database of Systematic Reviews” This review concludes that although observational studies suggest a potential inverse association between selenium exposure and cancer risk, randomized trials show no convincing evidence that selenium supplements prevent cancer in humans and may indicate harmful effects.
38 citations
,
February 2019 in “Clinical Interventions in Aging” This meta-analysis found that dutasteride was more effective than finasteride in increasing hair count and improving photographic assessments for men with androgenetic alopecia, while both drugs had similar rates of sexual dysfunction-related adverse effects.
30 citations
,
February 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This review found moderate to very low-quality evidence that spironolactone, flutamide, and cyproterone acetate combined with oral contraceptives may reduce hirsutism more effectively than placebo or metformin, though results vary among other treatments.
22 citations
,
August 2015 in “Cochrane Database of Systematic Reviews” The study aims to find the best treatment for central serous chorioretinopathy by comparing various options.
12 citations
,
June 2023 in “JAMA network open” In this study of seven randomized clinical trials, JAK inhibitors were associated with improved hair regrowth outcomes in alopecia areata patients compared to placebo, with oral administration being more effective than external application, though longer trials are needed to confirm safety and effectiveness.
12 citations
,
December 2022 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This review suggests that oral Janus kinase inhibitors are a promising treatment for alopecia areata in adults, showing significant hair regrowth with fewer side effects than conventional treatments, while PDE-4 inhibitors and biologics show limited efficacy.
July 2026 in “International Journal of Drug Delivery Technology” This review of non-surgical treatments for androgenetic alopecia reports that combination therapies, particularly platelet-rich plasma with low-level laser therapy, tend to be more effective than using each treatment alone.
December 2025 in “Cureus” This source details the process necessary to substantiate "clinically proven" claims for products, emphasizing the importance of rigorous clinical trials, regulatory compliance, and emerging technologies in ensuring safety, efficacy, and credibility across diverse populations and settings.
July 2025 in “Journal of Investigative Dermatology” Probiotics significantly reduce the severity of atopic dermatitis.
October 2024 in “Skin Appendage Disorders” This bibliometric analysis reported that PRP is most frequently studied for hair restoration, especially in placebo-controlled trials, although differences in PRP preparation and outcome measures challenge result consistency across studies.
June 2024 in “Journal of cosmetic dermatology” This study reviewed the publication trends and key findings on alternative therapies for androgenetic alopecia, highlighting the increasing research interest in dutasteride and nontopical minoxidil, while noting a lack of high-quality trials for nontopical minoxidil formulations.
April 2024 in “Expert opinion on investigational drugs” In this study, JAK inhibitors were reported as safe and effective treatments for moderate-to-severe chronic alopecia areata, although the appropriate duration of treatment remains uncertain, as stopping these medications often results in relapse.
This study found that platelet-rich plasma injections significantly improved hair density in male patients with androgenetic alopecia compared to placebo treatments.
Results are not reported for this review, which aimed to gather evidence on the effect of platelet-rich plasma monotherapy for androgenetic alopecia in men and women.
March 2017 in “BJU international” This article discusses the BJUI's strategies to support urology-related clinical trials but reports no new experimental results; the authors emphasize the importance of rigorous trial design and reporting standards.
379 citations
,
May 2016 in “Cochrane library” This review concluded that corticosteroids improve muscle strength and function in boys with Duchenne muscular dystrophy over short-term periods, but evidence on prolonging walking ability remains insufficient, and side effects are common.
369 citations
,
June 2013 in “Biochimie” This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.
164 citations
,
April 2008 in “Cochrane library” This review of interventions for alopecia areata found no significant treatment benefits for hair growth compared to placebo, indicating a need for larger, well-conducted studies.
79 citations
,
October 2015 in “Journal of Dermatological Treatment” This review assesses the use of platelet-rich plasma in dermatology and concludes that while there may be modest benefits for certain conditions, more evidence is needed before it can be widely recommended.
53 citations
,
July 2018 in “Journal of cosmetic dermatology” This review summarizes clinical and comparative trials on platelet-rich plasma in dermatology and concludes that while PRP shows significant improvements, more randomized controlled trials are needed to confirm its effectiveness for widespread use.
51 citations
,
August 2021 in “Turkish Journal of Medical Sciences” This review concluded that monoclonal antibodies are currently the most effective treatment for COVID-19, with potential efficacy of high-titer convalescent plasma when used early, while multiple other drugs require further evaluation to determine their effectiveness.