March 2026 in “International Society of Hair Restoration Surgery” In this study, researchers systematically reviewed the clinical outcomes of exosome-based therapies for alopecia, reporting promising but low-certainty evidence of improvements in hair density and thickness, with mainly mild adverse effects, and highlighting the need for larger, well-designed trials.
April 2025 in “Annals of Medicine” This study assessed the combination of compound glycyrrhizin and conventional treatments for alopecia areata and found it effective for promoting hair regrowth while being safe with mild adverse effects, based on a systematic review and meta-analysis of randomized controlled trials.
February 2025 in “PubMed” This article discusses the need for rigorous trials to compare the effectiveness and safety of CAM supplements with conventional dermatologic therapies, reporting no new findings.
57 citations
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August 2023 in “American Journal of Clinical Dermatology” JAK inhibitors and platelet-rich plasma show promise for treating alopecia areata.
32 citations
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September 2016 in “Dermatologic Surgery” This review discusses the current evidence and highlights gaps in research needed for the wider acceptance of low-level laser therapy as a treatment for hair loss; no new clinical results are provided.
27 citations
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May 2019 in “American Journal of Clinical Dermatology” This systematic review found insufficient evidence to make robust recommendations for using antiandrogen therapies in treating hidradenitis suppurativa/acne inversa and suggests that further randomized controlled trials are necessary.
16 citations
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November 2016 in “Journal of Cosmetic and Laser Therapy” This review highlights that laser and light treatments could serve as safe and effective alternatives to current therapies for alopecia areata, with the excimer laser showing positive results, though further randomized controlled trials are necessary to establish optimal treatment protocols.
Prescription and alternative therapies for hair loss will be compared for effectiveness.
1 citations
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March 2023 in “Frontiers in Medicine” This meta-analysis found that topical prostaglandin analogs could significantly improve hair length and density in patients with hair loss, compared to placebo, without notable safety differences.
1 citations
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August 2020 in “Journal of The American Academy of Dermatology” This letter discusses the variability in platelet-rich plasma preparation for androgenetic alopecia treatment and highlights that different methods yield varied platelet concentrations but not significant differences in growth factor secretion per platelet.
June 2026 in “Skin Appendage Disorders” This source reviews the use of topical tretinoin with minoxidil for androgenetic alopecia, indicating that while combined use may convert some minoxidil nonresponders to responders, clinical evidence is limited and increased absorption may lead to irritation concerns.
November 2025 in “Aesthetic Surgery Journal Open Forum” This meta-analysis reported that platelet-rich plasma significantly improved patient satisfaction and objective efficacy in treating skin aging, while not significantly increasing adverse effects.
November 2025 in “Journal of Family Medicine and Primary Care” This systematic review and meta-analysis found that low-dose minoxidil treatment effectively enhances facial hair development with relatively minimal side effects, which can be beneficial in primary care settings.
August 2024 in “PLoS ONE” This study reviewed randomized controlled trials to assess whether adding platelet-rich plasma injections to a Minoxidil regimen offers any benefit in treating androgenetic alopecia, but results are not reported in the abstract.
January 2024 in “Updates in clinical dermatology” Photobiomodulation effectively stimulates hair growth and reduces hair loss.
September 2023 in “International Journal of Trichology” In this study reviewing recent literature, researchers found limited high-quality evidence supporting the use of adipose-derived stem cells for androgenic alopecia and alopecia areata, suggesting a need for further randomized controlled trials to better assess their efficacy.
May 2023 in “Clinics in Plastic Surgery” This study suggests that platelet-rich plasma injections are a promising option for the treatment of androgenetic alopecia, both alone and as an addition to other nonsurgical and surgical treatments.
December 2017 in “Huisarts En Wetenschap” Finasteride helps hair growth in early male baldness, but more long-term research needed.
June 2012 in “Prescriber” Topical minoxidil effectively and safely treats female pattern hair loss, but other treatments need more research.
May 2011 in “MOspace Institutional Repository (University of Missouri)” In this study, finasteride 1 mg daily did not improve hair loss in normoandrogenic postmenopausal women and had a similar adverse event profile to placebo within the first year.
January 2025 in “JAAD International” This randomized, controlled clinical trial found that combining 25 mg/d bicalutamide with 1 mg/d minoxidil for 24 weeks did not enhance hair density improvement in female pattern hair loss compared to 1 mg/d minoxidil alone, with no significant difference observed between the groups.
37 citations
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October 2017 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This literature review reported that scalp hypothermia significantly decreases the occurrence of chemotherapy-induced alopecia, increasing effectiveness by 2.7-fold in controlled clinical trials and 3.9-fold in randomized trials, and highlighted a need for standard guidelines for its use.
72 citations
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July 2014 in “American journal of clinical dermatology” This review analyzed randomized controlled trials on alopecia areata treatment and found that while several treatments showed effectiveness, most studies had limitations affecting their interpretability.
January 2015 in “Zurich Open Repository and Archive (University of Zurich)” This study found no significant difference in anagen rate improvement between the CYP-based dietary supplement and placebo in women over 60 with telogen effluvium, possibly due to variable patient inclusion related to hair growth seasonality.
2 citations
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September 2023 in “PubMed” The studies reviewed found favorable treatment outcomes for hypopigmented scars using PGF2α agonists with no adverse events reported. However, the authors highlight the need for larger randomized controlled trials to better understand their effectiveness and long-term safety.
21 citations
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August 2013 in “Journal of Dermatological Treatment” This review discusses the mixed evidence and high risk of bias in studies on low-level light therapy for treating androgenetic alopecia and calls for rigorous randomized controlled trials to assess its efficacy.
21 citations
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June 2017 in “Journal of The American Academy of Dermatology” This study reviewed existing articles to assess the efficacy of topical diphenylcyclopropenone immunotherapy for alopecia areata, but it did not report new clinical results.
19 citations
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November 2011 This review discusses the topical use of systemic drugs for cutaneous disorders and reports a lack of strong evidence from randomized controlled trials, highlighting the need for larger comparative effectiveness studies.
March 2023 in “East African scholars journal of medical sciences” This review examines metformin use in PCOS treatment, noting that while non-randomized studies show improvements, randomized controlled trials suggest benefits are limited and highlight lifestyle changes as potentially more effective.
11 citations
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December 2019 in “Dermatologic Therapy” This systematic review suggests that topical ketoconazole may improve hair regrowth and thickness in both animal and human studies for androgenetic alopecia, but further randomized controlled trials are needed.