April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the natural estrogen Estetrol (E4) may promote hair follicle growth and prevent miniaturization, suggesting its potential as a treatment for hair loss disorders.
November 2022 in “Journal of Investigative Dermatology” This study found that marine-derived collagen peptides slightly promoted hair matrix proliferation and prolonged hair growth phase in human hair follicles ex vivo, suggesting potential benefits for hair loss treatment.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study observes that TYK2 inhibition with BMS-986202 may extend hair follicle growth phases and decrease inflammatory cell markers in alopecia areata, suggesting potential for clinical application.
This study suggests that bovine and fish-derived collagen peptides may help maintain or prolong the hair growth phase and balance hair follicle stem cell populations, potentially benefiting aging and hair loss conditions like androgenetic alopecia.
July 2022 in “Journal of Investigative Dermatology” The combination of a plant extract and a peptide can increase hair pigmentation and may reverse greying.
29 citations
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January 2021 in “Journal of Investigative Dermatology” This study demonstrates that dermal white adipose tissue regulates human hair growth and pigmentation through hepatocyte growth factor secretion, highlighting potential therapeutic targets for hair-related disorders.
March 2025 in “FEBS Journal” This study found that Epiprofin acts as a negative regulator of parathyroid hormone transcription, with potential implications for controlling PTH production in hyperparathyroidism.
220 citations
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June 2013 in “The Journal of Pathology” This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.
47 citations
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December 2011 in “Experimental Dermatology” This study suggests that the neuropeptide CGRP may protect against, but not restore, IFNγ-induced collapse of hair follicle immune privilege in alopecia areata.
23 citations
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September 2020 in “Journal of Dermatological Science” This pilot study suggests that skin-resident γδT-cells may play a significant role in the early stages of alopecia areata pathogenesis, indicating a potential new target for therapeutic management.
5 citations
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May 2024 in “BMC Biotechnology” This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.
4 citations
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July 2025 in “Frontiers in Pharmacology” This study found that cooling combined with antioxidants can improve scalp cooling effectiveness in preventing chemotherapy-induced alopecia by maintaining hair follicle viability and function.
6 citations
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June 2022 in “Journal of Orthopaedic Surgery and Research” In this animal study, oral administration of wedelolactone significantly improved bone mineral density and reduced osteoclast numbers in a model of particle-induced osteolysis, suggesting potential as a treatment option.
May 2025 in “Journal of International Medical Research” In this study, micrografting technology was found to potentially shorten healing time compared to other grafting techniques, especially in treating burns, though results showed high heterogeneity and a risk of bias.
This study found that platelet-rich plasma significantly enhanced the viability, as well as the expression of alkaline phosphatase and versican, in human hair dermal papilla cells compared to controls.
2 citations
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March 2023 in “Biomedicine & pharmacotherapy” This study found that platelet lysate significantly improved hair growth and follicle performance in both experimental settings and AGA patients, showing results comparable to platelet-rich plasma.
March 2024 in “Stem cell research & therapy” This study found that conditioned medium from human dental pulp stem cells (particularly under hypoxic conditions) improved keratinocyte survival and hair regrowth in a chemotherapy-induced alopecia mouse model and did not promote tumor growth, suggesting potential for safe therapeutic use.
January 2022 in “Experimental Dermatology” Minoxidil solution and foam both increase hair growth, but the solution works better than the foam.
8 citations
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January 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses how neuroendocrine regulation affects human hair follicles and suggests potential therapeutic targets, but it reports no new clinical results.
February 2026 in “International Journal of Molecular Sciences” This study found that knocking down the gene SFRP1 in human hair follicles ex vivo prolonged the hair growth phase and increased keratinocyte proliferation, suggesting potential as a therapeutic target for maintaining hair growth in male pattern baldness, while DKK1 knockdown showed no effect.
39 citations
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January 2021 in “BioMed Research International” This review explores the variability in platelet-rich plasma therapy outcomes across different medical applications, attributing disparities to inconsistent blood processing methods, and it reports no new clinical results.
31 citations
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October 2021 in “Antibiotics” This study observed that post-surgical use of chlorhexidine digluconate mouth rinse in patients may induce a fibrotic transformation in gingival tissue, promoting a scar-like wound healing response.
11 citations
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December 2024 in “Wound Repair and Regeneration” In this study, researchers created the WRAHPS Guidelines to standardize the reporting of preclinical wound healing studies, aiming to improve transparency, enable comparative analysis, and support the development of human clinical trials for wound healing disorders.
6 citations
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August 2024 in “Biomacromolecules” This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.
January 2026 in “Clinical Dermatology Review” This study found that platelet-rich plasma therapy significantly improved hair density, diameter, and reduced inflammation in androgenetic alopecia patients compared to placebo, though individual responses varied.
August 2023 in “Stem Cell Research & Therapy” This study found that cell-free fat extract (CEFFE) enhanced hair growth in mice with androgenetic alopecia by increasing hair follicle density and promoting proliferation while regulating the DHT/AR pathway.
February 2023 in “Journal of Advanced Research” This study found that platelet-rich plasma microneedles promoted hair regrowth in mice by facilitating angiogenesis and cell proliferation, showing promise for a minimally invasive hair regeneration treatment.
March 2021 in “Türk plastik cerrahi dergisi” In this study, activated platelet-rich plasma injections significantly increased hair count, density, and the anagen/telogen ratio in men with androgenetic alopecia, compared to placebo, suggesting it as a safe alternative to medical treatments for early-stage alopecia.
158 citations
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May 2003 in “Journal of Investigative Dermatology” This study observed that hair follicle mesenchyme in mice exhibits significant plasticity during the hair cycle, with cell migration and changes in papilla size impacting hair production.
149 citations
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June 2010 in “The FASEB journal” In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.