April 2022 in “Molecules” This study identified two potent 5α-reductase inhibitors from Tectona grandis leaves, and suggests that ethanol is a preferable solvent for extracting these compounds, which are potential ingredients for hair loss treatments.
This study found that some white or grey hairs can naturally regain pigmentation, suggesting hair greying may be reversible in certain conditions linked to psychological stress.
March 2015 in “Journal of Visualized Experiments” This study developed a simple and reliable technique to quantify hair loss in mice, potentially enhancing assessment and comparison of new alopecia therapies in preclinical research.
December 2024 in “Tissue and Cell” In this study, researchers developed a method to automatically detect androgen receptor nuclear translocation in dermal papilla cells using fluorescence markers and image analysis, finding that the receptor's nuclear signal peaks about 20 minutes after DHT exposure.
January 2024 in “International Journal of Biological and Environmental Investigations” This study developed and validated a reliable RP-HPLC method for accurately quantifying dutasteride in pharmaceutical formulations and bulk pharmaceuticals using a Shiseido C18 analytical column, demonstrating precision, accuracy, and sensitivity across a concentration range of 10 to 22 ppm.
48 citations
,
May 2019 in “Genome Biology” This study identified genetic, biological, and technical factors that influence circRNA expression in the human brain, connecting these factors to potential genetic risk for diseases like schizophrenia and type II diabetes.
40 citations
,
July 2013 in “Skin Pharmacology and Physiology” This study reports that among men, skin surface hydration and pH change with age, but transepidermal water loss and sebum production show less variation.
16 citations
,
February 2014 in “Journal of Investigative Dermatology” This study developed a mouse model to monitor hair follicle cycling macroscopically through live bioluminescence imaging, enabling detailed analysis of hair cycle and propagation dynamics influenced by environmental factors.
10 citations
,
January 1980 in “Ultrastructural pathology” This study suggests that elevated copper levels in domestic tapwater, exacerbated by its aggressive properties, likely contribute to green hair by damaging the cuticle and increasing copper uptake.
January 2019 in “Data Archiving and Networked Services (DANS)” This review discusses various approaches to skin tissue engineering and the evaluation of skin substitutes, highlighting the need for more objective assessments and improved understanding of skin regeneration.
April 2018 in “Journal of Investigative Dermatology” In laboratory models of human skin, this study found that treating with resveratrol significantly increased glutathione levels, potentially enhancing the skin's antioxidant defenses.
March 2018 in “Vìsnik farmacìï” This study identified flavonoids and phytosterols in a medicated cosmetic cream developed for androgenic alopecia and proposed methods for their identification and quantification.
4 citations
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December 2020 in “Natural Product Sciences” This study identified ten compounds from Eclipta prostrata, with some displaying potent inhibitory effects against α-glucosidase and acetylcholinesterase enzymes.
20 citations
,
December 1995 in “Journal of Chromatography B: Biomedical Sciences and Applications” Accurate method measures finasteride levels in human plasma using gas chromatography-mass spectrometry.
19 citations
,
January 2008 in “Journal of Pharmacy and Pharmacology” This study found that porcine skin serves as a reliable model for studying drug absorption into human hair follicles, showing a strong correlation in follicular drug absorption between porcine and human skin.
16 citations
,
February 2015 in “Photochemistry and Photobiology” The researchers reported that hair offers a measurable protective barrier against UVB and UVA radiation, which increases with hair density, thickness, and melanin content, suggesting a role in skin cancer prevention.
12 citations
,
July 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This study observed phenotypic diversity in hair loss among Japanese individuals homozygous for the LIPH c.736T>A mutation and suggests that differences in hair thickness may contribute to varying severities.
11 citations
,
September 2021 in “Skin Appendage Disorders” This study observed variability in hair density and types across different scalp areas in cadaver biopsies, providing reference values that could aid in diagnosing hair disorders in Asians.
6 citations
,
December 2018 in “Australasian Journal of Dermatology” This study found a strong correlation between the Sinclair Scale and cumulative hair thickness density, allowing the estimation of the Sinclair Scale from trichoscopy-derived statistics.
2 citations
,
February 2023 in “International journal of molecular sciences” This study explored a multidimensional approach to examine body hairs' physico-chemical properties, potentially supporting their use over scalp hairs in forensic and intoxication studies.
2 citations
,
January 2016 in “SANGYO EISEIGAKU ZASSHI” This study found that nearly all nurses caring for chemotherapy patients showed detectable levels of cyclophosphamide in their urine, indicating significant occupational exposure to this antineoplastic drug.
January 2024 in “International Journal of Clinical Pharmacokinetics and Medical Sciences” The researchers in this study suggest that using plant-based hair serums, which combine herbs and botanical phytochemicals, can enhance therapeutic benefits for hair and skin, offering improvements like deep nutrition, skin suppleness, and UV protection compared to individual herb use.
October 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study reports that fly blood progenitors in a long-term organ culture model undergo symmetric cell divisions influenced by cell size and orientation, with infection triggering changes in cell differentiation kinetics.
This study found that inhibiting mTORC2 in glioblastoma cells reduced DNA repair and increased apoptosis, highlighting its potential role in cancer cell survival and DNA damage response.
60 citations
,
October 2010 in “Molecular Imaging and Biology” This study observed that skin pigmentation significantly attenuates bioluminescent signals in C57Bl/6 mice, complicating quantitative optical imaging and requiring consideration in experimental design.
31 citations
,
February 2020 in “BioMed Research International” This study found that in the Thai population, hair density varies by scalp location and decreases with age, and that Asians generally have lower hair density compared to Caucasian and African populations.
31 citations
,
December 2017 in “Skin Appendage Disorders” The study observed that Americans of Hispanic descent have a statistically significant higher hair density than individuals of African descent but lower than Caucasians, which may assist in diagnosing and researching hair disorders.
24 citations
,
September 2019 in “Journal of The American Academy of Dermatology” This study found that using very-low-dose oral minoxidil (0.25 mg/d) led to improvement or stabilization of hair parameters in 40% to 60% of men with androgenetic alopecia, although results were not statistically significant for the overall group.
15 citations
,
January 2015 in “Analytical Methods” Method accurately measures finasteride in tablets using finasteride-BSA interaction.
3 citations
,
September 2019 in “Journal of The American Academy of Dermatology” In this correspondence, researchers reported that very-low-dose oral minoxidil (0.25 mg/d) showed some effectiveness in stabilizing trichoscopic parameters in male androgenetic alopecia. However, their analysis suggests that higher doses (2.5–5 mg/d) may lead to better clinical responses with similar rates of adverse events.