![Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1](/images/research/ff6e6cbe-cb9c-4d11-87ef-671d28ffd4fa/small/15506.jpg)
research Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5α-Reductase 1
Benzo[c]quinolizin-3-ones are effective nonsteroidal inhibitors of human steroid 5α-reductase 1.
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research Characterization and Quantification of Wound-Induced Hair Follicle Neogenesis Using In Vivo Confocal Scanning Laser Microscopy
In vivo confocal scanning laser microscopy is an effective, non-invasive way to study and measure new hair growth after skin injury in mice.
research Analysis of Quantitative Changes in Hair Growth During Treatment With Chemotherapy or Tamoxifen in Patients With Breast Cancer: A Cohort Study
Chemotherapy causes hair loss starting soon after treatment begins and recovers about 3 months after ending, while tamoxifen does not significantly affect hair growth.
research The Suitability of Polycystic Ovary Syndrome-Specific Questionnaires for Measuring the Impact of PCOS on Quality of Life in Clinical Trials
The PCOS-specific questionnaire needs more work to fully measure quality of life in clinical trials.
research Health-Related Quality of Life and Physical Well-Being Among a 63-Year-Old Cohort of Women With Androgenetic Alopecia: A Finnish Population-Based Study
Women with androgenetic alopecia experience worse physical well-being and quality of life, but similar mental health compared to those without it.
research Comparison of Quality of Life in Patients with Androgenetic Alopecia and Alopecia Areata
Both androgenetic alopecia and alopecia areata negatively impact quality of life, with no significant difference between them.
research Oral Finasteride Improved the Quality of Life of Androgenetic Alopecia Patients
Finasteride helps hair loss patients' quality of life.
research Systematic Review and Quality Analysis of Studies on the Efficacy of Topical Diphenylcyclopropenone Treatment for Alopecia Areata
Topical DPCP is somewhat effective for hair loss in alopecia areata, but more research is needed.
research iTRAQ-Based Quantitative Proteomic Comparison of Early- and Late-Passage Human Dermal Papilla Cell Secretome in Relation to Inducing Hair Follicle Regeneration
Early-stage skin cells help regenerate hair follicles, with proteins SDF1, MMP3, biglycan, and LTBP1 playing key roles.
research Metformin Improved Health-Related Quality of Life in Ethnic Chinese Women with Polycystic Ovary Syndrome
Metformin helped improve the quality of life for Chinese women with PCOS, especially in physical health and symptoms like infertility, acne, and hair loss.
research Health-Related Quality of Life in Women with Polycystic Ovary Syndrome Attending a Tertiary Hospital in Southeastern Spain: A Case-Control Study
Women with Polycystic Ovary Syndrome (PCOS) have a lower health-related quality of life, especially those with an anovulatory phenotype, and may need specific interventions to improve it.
research Roles of MED1 in Quiescence of Hair Follicle Stem Cells and Maintenance of Normal Hair Cycling
MED1 is essential for normal hair growth and maintaining hair follicle stem cells.
research Effects of Polycystic Ovary Syndrome on Health-Related Quality of Life
PCOS lowers quality of life, causing issues like obesity, infertility, and menstrual problems.
research Health-Related Quality of Life, Depression, and Self-Esteem in Patients With Androgenetic Alopecia
Androgenetic alopecia negatively affects quality of life and self-esteem, especially in women, but not depression.
research Evaluation of Cohen's Cross-Section Trichometer for Measuring Hair Quantity
The trichometer is a quick and reliable tool for measuring hair quantity.
research Understanding Key Symptoms, Side Effects, and Impacts of HR+/HER2- Advanced Breast Cancer: Qualitative Study Findings
Patients with HR+/HER2- advanced breast cancer commonly experience fatigue, hair loss, and pain, which significantly affect daily activities.
![Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1](/images/research/c687900f-ea40-4de1-8f0b-a5b818951b1c/small/15452.jpg)
research Effect of C-Ring Modifications in Benzo[c]quinolizin-3-ones, New Selective Inhibitors of Human 5α-Reductase 1
Changing the C-ring structure in certain compounds can make them better at blocking a specific human enzyme.
research Scalp Extension: A Quantitative Study
Scalp extenders improve the results of scalp reduction for baldness but can cause severe headaches.
![Synthesis and Activity of 8-Substituted Benzo[c]quinolizin-3-ones as Dual Inhibitors of Human 5α-Reductases 1 and 2](/images/research/efc54340-66d6-4f27-9930-045ac023f903/small/15248.jpg)
research Synthesis and Activity of 8-Substituted Benzo[c]quinolizin-3-ones as Dual Inhibitors of Human 5α-Reductases 1 and 2
New compounds were made that effectively block enzymes related to prostate issues and hair loss.
research Evaluation of Quality of Life of Patients with Hirsutism Among Turkish Women: A Single-Center Cross-Sectional Study
Turkish women with hirsutism experience lower quality of life, especially those with PCOS, regardless of hair growth severity.
research Different Ligands of the TRPV3 Cation Channel Cause Distinct Conformational Changes as Revealed by Intrinsic Tryptophan Fluorescence Quenching
Different ligands change the shape of the TRPV3 ion channel in unique ways.
research Isolation and Quantification of Glycosaminoglycans from Human Hair Shaft
Human hair contains more glycosaminoglycans in children than adults, and these compounds decrease with age, possibly affecting hair thickness.
research Simultaneous LC-MS/MS Quantification of Glucocorticoids, Melatonin, and Its Metabolites in Hair
The new method can measure sleep-related hormones in hair effectively and could help track long-term sleep patterns.
research Histomorphological and Quantitative Characteristics of Black and Gray Human Scalp Hair
Gray hair has more continuous medullation and a higher medullary diameter than black hair.
research TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cells on Hair Follicle Regeneration
Bone marrow stem cells and their medium help hair regrowth.
research Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application
The model can help predict how finasteride and minoxidil work when applied to the scalp.
research Mapping of Cis-Acting Expression Quantitative Trait Loci in Human Scalp Hair Follicles
Researchers identified genes in scalp hair follicles that may affect hair traits and hair loss.
research Establishing and Prioritizing Research Questions for the Prevention, Diagnosis, and Treatment of Hair Loss (Excluding Alopecia Areata): The Hair Loss Priority Setting Partnership
The study identified the top 10 most important areas for future hair loss research.
research A Fast and Efficient UPLC-ESI-MS/MS Method for Detection, Identification, and Quantitative Analysis of Bioactive Substances in Medicinal Herbal Extracts for Preventing Hair Loss
Researchers developed a quick and sensitive method to identify and measure hair growth-promoting substances in a herbal mix.
research Bio-Monitoring of Air Quality Using Leaves of Trees and Lichens in Urban Environments
Tree leaves and lichens can effectively indicate air pollution levels in cities.