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In this study, recurrent vaginal bleeding in pre-pubertal girls was most often not linked to hormonal abnormalities, with two cases caused by foreign bodies that were resolved upon removal.

This study found that boys in Mexico City with selenium intake below the recommended dietary allowance had lower odds of progressing to advanced stages of pubertal development, while no association was observed in girls.

In this case study, a 7-year-old girl was diagnosed with Isolated Premature Pubarche after presenting with pubic hair growth and normal hormonal and bone age assessments.

This review discusses various skin lesions associated with endocrinologic disorders such as Cushing's syndrome and adrenal insufficiency, and it reports no new clinical results.

This study found an association between higher phthalate exposure and increased incidence of precocious puberty in girls, suggesting a need to reduce children's exposure to these endocrine disruptors.

This review discusses current knowledge of isolated premature pubarche in infants and reports no new findings, highlighting it as a mild, self-limiting condition that necessitates exclusion of serious causes.

This study suggests that ultrasound and color Doppler analyses may enhance the differential diagnosis of GnRH-dependent precocious puberty in girls with premature breast development or pubic hair growth.

This study observed that girls in rural Bangladesh experienced pubertal milestones later than in some other populations, but progressed through puberty at a similar pace from breast development to menarche.

This review highlights therapeutic options for inducing puberty in males and females with delayed puberty, emphasizing the need for larger trials to establish the best approaches.

This case report from a German study detailed a 2-year-old girl with virilization and precocious puberty due to a rare ovarian steroid cell tumor, finding that post-surgery, her elevated hormone levels normalized within a week, and ongoing follow-up showed no need for chemotherapy.

This study found that 20% of children initially diagnosed with premature pubarche were later identified with different clinical conditions during follow-up, highlighting the need for careful differential diagnosis over time.

This study found that older age at puberty may be associated with lower semen quality and altered reproductive hormone levels in young men, though only some results were statistically significant.

This case report illustrates a rare instance of mixed germ cell tumor in the pituitary with hyperandrogenism, emphasizing the importance of thorough examination and hormone evaluation in identifying hormonal dysfunctions.

This review summarizes the clinical features and molecular causes of Primary Generalized Glucocorticoid Resistance, highlighting new findings from the characterization of mutations in the NR3C1 gene, but reports no new experimental results.

This study reported that treatment with cyproterone acetate alone and then with incremental estrogen doses induced mild feminizing effects in late-pubertal trans-girls, with further feminization observed after adding estrogen.

This review discusses the role of oestrogens in stimulating growth hormone secretion and influencing linear bone growth in children, and reports no new clinical results; the authors suggest that oestrogens play a key role in pubertal growth spurts for both genders.

This case report highlights the need to consider complementary and alternative medicine use in endocrine evaluations, as stopping lavender oil use coincided with normalization of a concerning lab finding in a girl with precocious puberty signs.

In this study, reduced androgen receptor gene methylation and shorter CAG repeats in children with premature pubarche may lead to increased hair follicle sensitivity to steroid hormones, potentially causing early pubic hair development.

This article reviews the discovery and various physiological effects of cyproterone acetate, reporting its established indications for several androgen-driven conditions but providing no new clinical data.

This review discusses the pathophysiology, molecular genetics, and management of non-classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency, with no new clinical findings reported.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.

This article compiles evidence on prescribing estrogen for hormonal imbalance in women, emphasizing it should be personalized and carefully managed by healthcare providers based on individual cases.

Acne can appear or persist in adulthood due to hormonal changes, external factors, or substance use, and requires appropriate treatment.

This study found that SRD5A2 expression is absent in one third of benign adult prostates and is associated with hypermethylation, suggesting potential personalization of treatment for prostatic diseases based on methylation status.

This review discusses clinical, hormonal, and genetic aspects of nonclassic adrenal hyperplasia and reports no new findings; the condition is highlighted as a potential cause of premature adrenarche and other symptoms in young people.

This study found that the LH response to nafarelin effectively distinguished gonadotropin deficiency from constitutional delay of puberty, performing comparably to the sleep test and offering certain advantages.

This review examines the causes, assessment, and treatment options for hirsutism but presents no new clinical findings, highlighting the need for further research on managing this condition.

This study reports that patients with androgenetic alopecia had lower quality of life scores across all measured domains compared to controls, with disease severity worsening the impact, particularly socially for those under 30.

This study found that androgenetic alopecia is a significant yet under-recognized cause of hair loss in children and adolescents, often linked to family history and typically diagnosed by clinical examination.

This study found that exposure to phytoestrogens, bisphenol A, parabens, and phthalates was associated with developing idiopathic premature thelarche in girls.