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This study found that Phaeodactylum tricornutum extract enhanced hair follicle cell proliferation, indicated by increased keratin and ERK1/2 signaling, suggesting its potential for hair care applications.

Blocking a protein called prostaglandin D2 might help treat hair loss.

In this study, researchers found that miR-199a-3p plays a regulatory role in hair follicle development via the PTPRF/β-catenin axis and established a mouse model of alopecia areata by downregulating this small RNA, suggesting its potential value in studying alopecia diseases.

This study suggests that biallelic loss of the Hedgehog signaling repressor Patched alone in Keratin 5+ epidermal cells is insufficient to drive basal cell carcinoma development unless exogenous stimuli trigger accumulation of BCC precursor cells.

This case report describes an unusual occurrence of late-onset nevus comedonicus affecting both eyelids, with complications including bilateral ptosis and ectropion.

This letter reports a woman with nevoid basal carcinoma syndrome and pronounced androgenic alopecia associated with a novel PTCH gene mutation p.Leu1159fsx32, suggesting a genetic link in this case study.

This study observed that the degradation product PTeCA significantly increased in hair treated with oxidative cosmetics, suggesting it could be a reliable marker for detecting such treatments, with a proposed PTCA cut-off value using PTeCA as the gold standard.

This case report describes how anifrolumab, used beyond trial-eligible populations, led to significant clinical and serological recovery in a 45-year-old woman with organ-threatening systemic lupus erythematosus complicated by infection and resistant to conventional treatments like cyclophosphamide and rituximab.

In this case report, a three-generation family with Gorlin-Goltz syndrome showed a heterozygous PTCH1 splice-donor variant associated with the disease, and two affected relatives benefited from individualized, side-effect-guided dosing of the drug sonidegib, experiencing regression of basal cell carcinoma lesions.

This study suggests that the key mechanism of stress-related hair loss involves CRH-induced PTEN loss, which reduces autophagy and increases apoptosis in dermal papilla cells, highlighting potential therapeutic targets like PTEN activation or autophagy enhancement.

This study found that stress-related hair loss may be driven by CRH-mediated mechanisms that inhibit autophagy and increase apoptosis in dermal papilla cells, suggesting potential therapeutic targets like PTEN activation or rapamycin to enhance autophagy.

In this study using mouse models, researchers found that stress-related hair loss may occur due to CRH-induced PTEN loss and inhibition of autophagy via the PI3K/AKT/mTOR pathway in dermal papilla cells, suggesting potential treatments through PTEN activation or autophagy enhancement.

In this study using C3H/HeJ mice, a single subcutaneous injection of the fusion protein PTH-CBD increased anagen hair follicle counts and promoted hair regrowth comparably to daily oral ruxolitinib, potentially by enhancing beta-catenin production and stimulating anagen transition.

This study found that tissue transcriptomics and a normalization approach can effectively cluster nine inflammatory skin diseases and identify specific biomarkers, including PTEN as a marker for cutaneous lupus erythematosus.

This study suggests that targeting mitophagy to regulate mitochondrial dysfunction and inhibit inflammasome activation could offer a novel therapeutic approach for alopecia areata.

In this study, a single subcutaneous dose of PTH-CBD showed similar hair regrowth to daily oral ruxolitinib in mice with alopecia, possibly through increased beta-catenin and anagen transition stimulation.

In this study with mice, simultaneous inactivation of Smad4 and PTEN genes led to rapid development of invasive forestomach squamous cell carcinomas, mirroring human esophageal SCCs.

In this study, the deletion of Smad4 and PTEN genes in mice was associated with rapid and invasive squamous cell carcinoma formation in the forestomach, modeling human esophageal cancer progression.

This study found that in mice with deregulated β-catenin and PTEN signaling, increased follicular hyperplasia and sebaceous gland changes occur, but typical papillomas do not develop, potentially due to p21 response and reduced stem cell markers.

Certain gene variants may raise the risk of prostate enlargement, but taking NSAIDs could reduce this risk.

PTHrP is important for bone formation and may be targeted for osteoporosis treatment and longevity therapies.

In this transgenic mouse study, preliminary findings suggest that overt melanocyte hyperplasia may require prior keratinocyte hyperplasia, indicating a potential role for keratinocyte mutation in early melanoma development.

The study found that high-dose intragastric administration of Pterocarpus indcus Willd extracts reduced hair loss and increased hair follicles in a rat model of androgenetic alopecia, but topical application did not show significant effects.

This study found that frontalis suspension surgery using autologous sling material effectively provided good to excellent long-term functional and aesthetic outcomes for children with severe congenital ptosis.

This case report identified lash ptosis as a potential complication of latanoprost therapy in a 61-year-old man with ocular hypertension.

This study found that lash ptosis was more common and severe in eyes with blepharoptosis, especially congenital, compared to normal eyes.

This study compared open and closed surgical techniques for severe congenital ptosis using Gore-Tex slings and found that the closed approach offered better functional outcomes, while the open method provided superior cosmetic results.

This study reported that direct brow lift surgery provided excellent and long-lasting results in bald men with high anterior hairlines, despite visibility of the scar in a few cases.

This article discusses the mechanisms and prevention of aging, particularly in facial rejuvenation, but reports no new experimental findings.

Terbinafine is more effective than itraconazole for toenail fungus, especially in older patients, and debridement improves its effectiveness.