Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

In this study, overexpression of ornithine decarboxylase accelerated basal cell carcinoma in Ptch1+/– mice under UVB exposure, while its inhibition reduced tumor induction, suggesting potential chemoprevention strategies in humans.

This study found that inhibiting the enzyme ornithine decarboxylase (ODC) prevented UVB-induced basal cell carcinomas in a mouse model, suggesting ODC is a potential target for chemoprevention strategies.

This study observed that Ptprq mutant mice exhibit significant abnormalities in hair bundle structure and vestibular dysfunction, suggesting similar issues may contribute to hearing loss and vestibular problems in humans with PTPRQ mutations.

This study found that high levels of parathyroid hormone-related protein expression can result in the production of shorter hair shafts, likely through effects on angiogenesis.

This study found that BMP2 increased PTEN expression and induced autophagy, promoting hair follicle stem cell differentiation in both in vitro models and a mouse wound model.

This study suggests that TIP39 and its receptor PTH2R, identified in human epidermis, may play a role in keratinocyte function and influence skin differentiation.

This study found that AR-positive breast cancer cell lines are more sensitive to the dual PI3K/mTOR inhibitor NVP-BEZ235 compared to AR-negative cells.

In this study, a single dose of PTH–CBD produced a sustained increase in bone mineral density for up to a year in mice, indicating its potential as an osteoporosis treatment.

This study found that PTEN regulates the number and genomic stability of hair follicle stem cells in the skin, with its deficiency leading to increased stem cell accumulation and senescence through interactions with BMAL1 and BMI-1.

This study suggests that NBCCS and BFHS may be the same genetic condition, which could help improve identification and management of misdiagnosed cases with specific surveillance strategies.

In this study, PTH-CBD effectively prevented and partially reversed chemotherapy-induced alopecia in mice, with pretreatment offering a better cosmetic outcome compared to therapeutic administration after hair loss onset.

The researchers reported that exosomes from hypoxic M2 macrophages, enriched with miR-26b-5p, promoted proliferation, migration, and invasion in human keloid fibroblasts through the PTEN-PI3K/AKT pathway, highlighting miR-26b-5p's role in keloid development.

This study found that in eyelids with ptosis, voluntary brow elevation raises the eyelid position similar to maximal eyelid opening, suggesting brow lifting is driven by efforts to elevate the eyelid.

In this study, both the Fox and modified Crawford frontalis sling techniques effectively improved ptosis and cosmetic appearance, with the modified Crawford technique resulting in less lagophthalmos.

This review discusses the causes and clinical presentations of ptosis in childhood and reports on several observed cases, but provides no new clinical results.

This article reviews the role of exosomes in promoting axonal regeneration and discusses recent findings on how exosome-borne molecules might influence the PTEN-mTOR pathway in injured neurons; it reports no new experimental results.

This study observed that MAA beads improved vascularization in non-diabetic male mice by modulating the Shh signaling pathway in wound granulation tissue, but showed no such effects in females.

This study found that contrast enhanced phototrichogram (CE-PTG) significantly improved detection of various hair types and growth stages in androgenetic alopecia compared to standard PTG and was comparable to biopsy analysis.

In this study, basal cell carcinoma developed in Ptch-deficient mice only after chemical treatment, not skin wounding, suggesting a second unknown event is necessary for tumor formation.

This study found a significant relationship between lash ptosis severity and marginal reflex distance, levator function, and double fold presence in Asian patients, which may inform surgical planning for upper eyelid procedures.

This study suggests that Ptprq in the hair bundles may exist as multiple isoforms that are differentially expressed throughout development and affect the organization of stereocilia in the chick inner ear.

This study suggests that the T allele of the SNP rs2476601 in the PTPN22 gene may increase the risk of alopecia areata, although further studies are necessary to validate this finding across different populations.

This meta-analysis found that the rs2476601 SNP of the PTPN22 gene is significantly associated with reduced susceptibility to alopecia areata, with carriers of the C-allele and CC-genotype having a lower risk.

This study found that hairless mice with homozygous mutations developed significantly more aggressive basal cell carcinomas and a heightened inflammatory response to UVB exposure compared to their haired littermates.

In this study, researchers found that inducing mitophagy can alleviate NLRP3 inflammasome activation in outer root sheath cells under conditions of mitochondrial stress, suggesting that targeting mitophagy and inflammasome interactions may offer new therapeutic approaches for alopecia areata.

This study observed that deleting PTEN in mouse facial motoneurons enhanced peripheral axon regeneration but also led to physiological changes and potential hyperplasia in older mice.

This study found that certain fatty acids and triterpenoid-glycosides from Eclipta prostrata L. leaves exhibit potent inhibitory effects on the protein tyrosine phosphatase 1B enzyme, suggesting potential anti-diabetic and anti-obesity benefits.

This study found that loss of the Ptch2 receptor in mice leads to increased incisor growth and enhanced mesenchymal stem cell differentiation, highlighting Ptch2's role in organ regenerative potential.

This laboratory study found that PI extract, along with its metabolites Ang and Mac, inhibited cell proliferation and protein expression linked to pathways involved in BPH, suggesting potential for therapeutic use, although the Ang-Mac combination showed no significant effect on apoptosis through the p53 pathway.

This study found that high-dose pterostilbene potentially reduced prostate hyperplasia and had strong antioxidant effects in male rats with benign prostatic hyperplasia, suggesting it might be more effective than vitamin C and resveratrol in similar contexts.