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    Glossary Proteolysis

    process of breaking down proteins into smaller peptides or amino acids

    Proteolysis is the process by which proteins are broken down into smaller peptides or amino acids through the action of enzymes called proteases. This biological mechanism is essential for various bodily functions, including digestion, cell regulation, and the removal of damaged or misfolded proteins.

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    1. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Science · 2016 · 242 citations
    2. Matriptase: Potent Proteolysis on the Cell Surface Molecular Medicine · 2006 · 165 citations
    3. Autosomal Ichthyosis with Hypotrichosis Syndrome Displays Low Matriptase Proteolytic Activity and Is Phenocopied in ST14 Hypomorphic Mice Journal of Biological Chemistry · 2007 · 101 citations
    4. Correlation of proteolytic activities of organ cultured intact mouse skin with defined hair cycle stages Journal of Dermatological Science · 1994 · 28 citations
    5. Enriching Proteolysis Targeting Chimeras with a Second Modality: When Two Are Better Than One Journal of Medicinal Chemistry · 2022 · 10 citations
    6. Proteolysis‐Targeting Chimera (PROTAC): Current Applications and Future Directions MedComm · 2025 · 9 citations
    7. Proteolysis‐targeting chimeras in cancer therapy: Targeted protein degradation for next‐generation treatment Cancer · 2025 · 3 citations
    8. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z‐protein in cells of the bulge region 1999 · 5 citations
    9. The effect of proteolytic enzymes on hair follicles of transgenic mice expressing the lac Z-protein in cells of the bulge region 1999 · 2 citations
    10. Proteolytic Enzymes Papain and Chymotrypsin Combined with Laser Techniques for the Management of Facial Hirsutism Planta Medica · 2022 · 1 citations
    11. Proteolytic depilation of lambskins : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of philosophy in Bioprocess Engineering at Massey University, Palmerston North, New Zealand Massey Research Online (Massey University) · 2008 · 1 citations
    12. Intramembrane Proteolysis of Astrotactins Journal of Biological Chemistry · 2017 · 8 citations
    13. Two novel MBTPS2 missense mutations impairing S2P proteolytic activity lead to IFAP syndrome with new phenotypic anomalies Journal of dermatological science · 2023
    14. Bioactive Proteolytic Enzymes Chymotrypsin and Papain as Adjuvants to Laser Hair Removal: Reducing the Risk of Paradoxical Hypertrichosis in Women with Facial Hirsutism Cosmetics · 2026
    15. Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway ˜The œAmerican journal of pathology · 2009 · 137 citations
    16. Comparative Transcriptome Analysis Reveals that a Ubiquitin-Mediated Proteolysis Pathway Is Important for Primary and Secondary Hair Follicle Development in Cashmere Goats PLoS ONE · 2016 · 31 citations
    17. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis Journal of Dermatological Science · 2017 · 8 citations
    18. Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium Cellular and Molecular Life Sciences · 2023 · 9 citations
    19. Chapter 3 Expression and Modification of Keratins During Terminal Differentiation of Mammalian Epidermis 1987 · 81 citations
    20. Mutations in SREBF1, Encoding Sterol Regulatory Element Binding Transcription Factor 1, Cause Autosomal-Dominant IFAP Syndrome American journal of human genetics · 2020 · 34 citations
    21. Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin 2015 · 28 citations
    22. Identification of Telogen Markers Underscores that Telogen Is Far from a Quiescent Hair Cycle Phase 2011 · 21 citations
    23. Dihydrotestosterone induces p27 degradation via direct binding with SKP2 in ovarian and breast cancer International Journal of Molecular Medicine · 2011 · 18 citations
    24. Expression of anti-aging type-XVII collagen (COL17A1/BP180) in hair follicle-associated pluripotent (HAP) stem cells during differentiation Tissue & Cell · 2019 · 11 citations
    25. Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System that Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice International Journal of Molecular Sciences · 2017 · 11 citations
    26. Localization of Cathepsins B, D, L, LAMP-1 and .MU.-Calpain in Developing Hair Follicles. ACTA HISTOCHEMICA ET CYTOCHEMICA · 2001 · 10 citations
    27. Lipid-based liquid crystals as drug delivery vehicles for antimicrobial peptides Chalmers Publication Library (Chalmers University of Technology) · 2017 · 5 citations
    28. Mechanical forces across compartments coordinate cell shape and fate transitions to generate tissue architecture Nature cell biology · 2024 · 2 citations
    29. Evolving CRBN ligands enhance the drug-like properties of protein degraders Journal of Enzyme Inhibition and Medicinal Chemistry · 2026
    30. Expanding the Scope of PROTACs: Opportunities and Challenges in Topical Delivery Journal of Medicinal Chemistry · 2025