10 citations
,
May 2020 in “Dermatology Research and Practice” This review discusses "follicular hypoglycania" as a potential pathology in hair growth disorders and reports that proteoglycan replacement therapy may improve hair loss treatments, though it presents no new clinical trial results.
10 citations
,
June 2014 in “Experimental Dermatology” The study found that exogenous decorin administration accelerated the anagen phase and delayed the catagen transition, suggesting it may act as a positive regulator of the hair cycle.
7 citations
,
May 1995 in “The journal of investigative dermatology/Journal of investigative dermatology” 
5 citations
,
September 2016 in “Journal of Cosmetic Dermatology” This article reviews postpartum hair loss management strategies, highlighting a lack of thoroughly investigated effective treatments and suggests that new research focus on targeted biological methods.
3 citations
,
October 2023 in “Bioscience Biotechnology and Biochemistry” In this animal study, researchers found that daily oral intake of salmon nasal cartilage proteoglycan enhanced hair growth in mice, potentially through a signaling pathway that stimulates specific growth factors in human follicle cells.
1 citations
,
August 2023 in “Biomolecules & therapeutics” In this study, researchers found that recombinant human HAPLN1 promoted hair growth in mice and human hair matrix cells by activating specific signaling pathways, suggesting it may offer a potential hair loss treatment with fewer side effects than existing medications.
1 citations
,
December 2017 This review found that androgenetic alopecia may be linked to increased cardiovascular and metabolic risks, but the relationship is not yet fully understood, and specific guidelines for cardiovascular disease detection and prevention in these patients have not been established.
January 2026 in “Frontiers in Medicine” In this study, PP-PTKL exhibited antioxidant, anti-inflammatory, and pro-melanogenic effects in laboratory settings, suggesting its potential role in preventing or treating hair greying. Further animal and human studies are needed to verify these findings.
April 2023 in “Russian Journal of Clinical Dermatology and Venereology” This study found that after a 4-month comprehensive therapy course, 90.5% of patients with androgenetic alopecia and telogen effluvium showed hair condition improvement, highlighting the potential benefits of adjuvant proteoglycan replacement therapy in these conditions.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study applied a new RGB trichrome stain to human skin samples, revealing distinct structural staining in normal tissues and potential proteoglycan-rich zones in hair follicles.
July 2021 in “Journal of dermatology research and therapy” In this study, researchers observed an increased incidence of pattern hair loss and telogen effluvium among COVID-19 patients, potentially linked to psychological stress, systemic inflammation, and oxidative stress, with reduced anagenic expression of proteoglycans suggested as a mediating mechanism.
This review discusses the link between COVID-19 and diffuse hair loss, focusing on the potential of proteoglycan replacement therapy with Nourkrin® to treat pattern hair loss and telogen effluvium in affected patients, and reports no new clinical results.
This review discusses the association between alopecia and increased cardiovascular and metabolic risk but reports no definitive clinical results, emphasizing the need for more comprehensive studies on androgenetic alopecia patients.
March 2023 in “Frontiers in Cell and Developmental Biology” This review covers the role of proteoglycans in tissue growth and regeneration and highlights several studies on their potential as therapeutic targets, but reports no new clinical results.
September 2021 in “Медицинский совет” This paper discusses various factors influencing hair loss, highlighting hormonal imbalances as a key factor in androgenetic alopecia and proposing proteoglycan-containing drugs as promising treatments to promote hair growth and prolong the anagen phase.
39 citations
,
November 2007 in “Journal of Histochemistry & Cytochemistry” This study found that in neonatal mice, the absence of the NG2 proteoglycan leads to reduced epidermal thickness and delayed subcutis thickening due to impaired proliferation and adipocyte deficiencies.
11 citations
,
October 2018 in “The Journal of Dermatology” This study suggests that decorin may help maintain hair follicle stem cells and its reduced expression could contribute to age-related hair loss.
4 citations
,
March 2022 in “Cosmetics” This review suggests that a dual treatment approach using Nourella® cream with nano-encapsulated Retilex-A® and per-oral Vercilex® tablets may effectively improve skin thickness, elasticity, and overall rejuvenation in aging skin, as shown in interventional studies.
67 citations
,
February 1994 in “Developmental dynamics” This study analyzed the distribution of adhesion molecules and extracellular matrix components in human fetal skin, suggesting their roles in hair follicle development.
51 citations
,
February 2004 in “Journal of Investigative Dermatology” MCSP may help identify and regulate skin stem cells, affecting hair growth and regeneration.
44 citations
,
July 1993 in “Journal of Investigative Dermatology” 9 citations
,
January 2021 in “Biomolecules” This study demonstrates the potential of infrared spectral imaging to assess hair follicle structures and heparan sulfate proteoglycan distribution across different phases of the hair growth cycle, offering promise for alopecia research.
20 citations
,
July 1987 in “Development Genes and Evolution” 
277 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.
88 citations
,
May 2005 in “Journal of Dermatological Science” In this study, specific versican expression was observed in the anagen phase of human hair follicles, suggesting its importance in maintaining normal hair growth.
77 citations
,
July 2013 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” This review discusses the impact of menopause-related oestrogen deficiency on skin ageing and suggests that oestrogen use may improve collagen and skin elasticity, but it reports no clinical trial results.
69 citations
,
August 2016 in “PubMed” This article discusses the relationship between cortisol, stress, and hair follicle function and highlights oral supplementation with a specific proteoglycan as a promising treatment for stress-related hair growth disorders, but it does not present new clinical results.
25 citations
,
March 2017 in “Experimental Dermatology” This review discusses various aspects of hair follicle biology and highlights unresolved questions and potential new research avenues, but presents no new experimental findings.
11 citations
,
December 1990 in “British Journal of Dermatology” This study observed abnormal extracellular matrix patterns in hair follicles from alopecia areata patients, particularly in the dermal papilla of large anagen follicles and in catagen follicles from lesional sites.
10 citations
,
August 2018 in “Experimental Dermatology” This study found that DECORIN promotes the proliferation and migration of outer root sheath keratinocytes in vitro and maintains the hair anagen phase in mice.