33 citations
,
July 2007 in “Skin research and technology” The study found that the break force of human hair significantly depends on hair diameter and strain, but not on age, gender, use of hair dye, or drugs.
30 citations
,
July 2000 in “PubMed” This study used advanced analytical techniques to reveal that proteins and lipids are distributed unevenly in hair, with distinct structural differences depending on their location within the fiber.
9 citations
,
September 2013 in “Journal of Applied Animal Research” This study identified eight alleles of the caprine KAP13-3 gene in cashmere goats, which could influence gene expression and cashmere fiber characteristics.
28 citations
,
October 1985 in “The Journal of Cell Biology” This study identified two types of hard alpha-keratin filament assemblies in developing human hair follicles, which may help investigate the structural framework of mammalian keratin appendages.
20 citations
,
November 1968 in “The Lancet” This study found that during dialysis, lower plasma-potassium levels were associated with hyperglycemia, suggesting potassium correction is vital when using glucose-rich dialysate.
4 citations
,
July 2022 in “International Journal of Cosmetic Science” This study found that the moisture sorption and desorption process can differentiate between cosmetic treatments of hair and provide insights into hair fibre structure changes, with bleaching causing greater symmetry breaking than perming.
This study identified genetic regions evolving at different rates in hairless mammals, suggesting that specific genomic changes may contribute to the evolution of hairlessness across various species.
November 2025 in “Cosmetics” This study evaluated a hair mask containing rice germ oil GX-N and ferulic acid on damaged hair and found that rice germ oil GX-N improved hair characteristics after bleaching, UV, and heat exposure, but adding ferulic acid did not provide extra benefits.
58 citations
,
November 2013 in “Journal of Innovative Optical Health Sciences” This review discusses the development and application of multiphoton microscopy in dermatology, highlighting its advantages and potential future research directions without reporting new clinical results.
47 citations
,
June 1996 in “International Journal of Legal Medicine” This article discusses how drug molecules integrate into hair fibers, focusing on biological transport mechanisms and physicochemical factors, but reports no new experimental findings.
38 citations
,
December 2006 in “Journal of Investigative Dermatology” Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.
29 citations
,
August 2011 in “PubMed” This study describes how shotgun proteomics can identify over 300 proteins in hair shafts, potentially allowing for the diagnosis of diseases through noninvasive human proteome sampling.
25 citations
,
March 2017 in “Experimental Dermatology” This review discusses various aspects of hair follicle biology and highlights unresolved questions and potential new research avenues, but presents no new experimental findings.
18 citations
,
January 2018 in “Advances in experimental medicine and biology” This review discusses the evolutionary history of keratins and reports no new results, highlighting key events that contributed to the development of mammalian hair and integument.
13 citations
,
March 2013 in “International Journal of Cosmetic Science” This study reports that the tetrapeptide AcSDKP significantly promotes skin and hair health in vitro and ex vivo, suggesting it could be used cosmetically to counteract skin aging and hair loss.
12 citations
,
May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that disrupting Lm332 expression in mice changes keratinocyte genetic expression, alters cell shape, and disrupts epidermal homeostasis, despite some compensatory anchorage by hair follicle basal cells.
9 citations
,
February 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” This review discusses the complexity and genetic organization of human keratin gene clusters and addresses the ongoing need for an updated unified naming system; it reports no new clinical results.
3 citations
,
September 2021 in “Data in brief” This study observed that bleaching brown human hair with persulfate salts and hydrogen peroxide induced significant conformational changes in keratin, particularly affecting disulfide bridges and oxidized sulfur species, which may inform the development of hair restorative treatments.
2 citations
,
February 2021 in “FEBS open bio” In this study, transfection experiments showed that mutations in the K85 gene affect filament formation with K35, which may impact hair formation related to ectodermal dysplasia.
June 2023 in “Historical records of Australian science/Historical Records of Australian Science” This biographical abstract highlights George Rogers' pioneering contributions to the understanding of keratin molecular structure and keratinisation biochemistry, including the application of electron microscopy to hair ultrastructure and the discovery of enzymes and gene transcription processes relevant to keratin proteins.
August 2019 in “Journal of Investigative Dermatology” This study found that tight junctions extend to the most superficial layer of the stratum granulosum in human skin, challenging previous claims of their limited presence in the epidermis.
20 citations
,
June 2012 in “British Journal of Dermatology” This study discusses the proteomic profile associated with hair damage but does not report new experimental findings.
23 citations
,
June 2012 in “Molecular Biology Reports” This study found that human outer root sheath cells express VEGF receptor-2, and exogenous VEGF165 significantly stimulates their proliferation through activation of the ERK signaling pathway.
19 citations
,
December 2015 in “Journal of Investigative Dermatology” This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.
7 citations
,
April 2012 in “Biomolecular concepts” This article reviews the role of keratins in epithelial function and structure, discussing their involvement in growth control, organelle functions, and pathomechanisms of disorders, but reports no new clinical results.
October 2021 in “Journal of Investigative Dermatology” This study found that fibroblasts from mature skin showed significantly reduced mechanical force production compared to young skin fibroblasts, suggesting age-related changes in cellular mechanical properties.
517 citations
,
February 2010 in “Materials” This review discusses the history and development of keratin biomaterials for biomedical uses, highlighting their biological activity and biocompatibility, and provides no new research findings.
208 citations
,
December 2003 in “Journal of Investigative Dermatology” This study found that dermal papilla and peribulbar dermal sheath cup cells in mice can both induce hair follicle formation, suggesting they may have similar functional roles in hair growth.
36 citations
,
November 2019 in “Molecular biology and evolution” This study suggests that the keratins found in reptile and bird skin appendages evolved independently from mammalian hair keratins, highlighting convergent evolution in these species.
11 citations
,
September 2010 in “American Journal of Medical Genetics - Part A” This study reports a mutation in the U2HR gene causing Marie Unna hereditary hypotrichosis in a Turkish family and notes eyebrow loss as a diagnostic clue.